MiR-182/Sestrin2 affects the function of asthmatic airway smooth muscle cells by the AMPK/mTOR pathway [0.03%]
MiR-182/Sestrin2通过AMPK/mTOR信号通路影响哮喘气道平滑肌细胞功能
Yali Xiao,He Zhu,Jiahui Lei et al.
Yali Xiao et al.
Background and objectives: Asthma is a chronic inflammatory airway disease and brings heavy economic and spiritual burdens to patients' families and the society. Airway smooth muscle cells (ASMCs) afect the development of...
Long-term blood pressure outcomes of laparoscopic adrenalectomy in trHTN patients [0.03%]
腹腔镜肾上腺切除术治疗特发性醛固酮增多症患者的长期血压结果
Yue Deng,Hanbo Wang,Xudong Guo et al.
Yue Deng et al.
Background and objectives: Treatment resistant hypertension (trHTN) is a common clinical problem faced by many clinicians. Laparoscopic adrenalectomy effectively trims blood pressure (BP) elevation secondary to various fu...
Network-guided neuromodulation for epilepsy: Unveiling the pathway to personalized therapy [0.03%]
网络引导的癫痫神经调节疗法：揭示个性化治疗途径
Peng Cao,Shun Gong,Liang Liu et al.
Peng Cao et al.
Approach to different thrombolysis techniques and timing of thrombolysis in the management of portal vein thrombosis in cirrhotic patients [0.03%]
门脉血栓形成患者经皮溶栓治疗的时机及不同溶栓技术的应用原则分析
Massimo Primignani,Giulia Tosetti,Anna Maria Ierardi
Massimo Primignani
Thrombolysis is not currently recommended in cirrhotic patients with acute portal vein thrombosis (PVT) in most guidelines, because of the exceedingly limited data and the perceived high risk of bleeding adverse events. However, in the few ...
Chronic stress-induced immune dysregulation in breast cancer: Implications of psychosocial factors [0.03%]
慢性压力诱导的乳腺癌免疫失调：心理社会因素的意义
Xiuyun Chen,Mozhi Wang,Keda Yu et al.
Xiuyun Chen et al.
Chronic stress refers to continuous emotional changes and psychological pressure that individuals experience when they are unable to adjust and stabilize the internal environment over an extended period. It can increase the pressure on endo...
FOSL2 participates in renal fibrosis via SGK1-mediated epithelial-mesenchymal transition of proximal tubular epithelial cells [0.03%]
FOSL2通过SGK1介导的近端小管上皮细胞间质转化参与肾纤维化
Naiquan Liu,Dongyang Li,Dajun Liu et al.
Naiquan Liu et al.
Background: Fos-related antigen 2 (FOSL2) plays a facilitative role in fibrotic disease; however, its role in renal fibrosis remains unclear. This study aimed to clarify the role and underlying mechanisms of FOSL2 in rena...
Tracing down the updates on Ebola virus surges: An update on anti-ebola therapeutic strategies [0.03%]
追踪埃博拉病毒疫情更新：抗埃博拉治疗策略的再思考
Shiza Malik,Yasir Waheed
Shiza Malik
Ebola virus (EBOV) related health complications have presented a great threat to the healthcare system in the endemic regions. The outbreaks of 2013-2016 and 2018-2020 brought along a huge healthcare burden for the afected communities. Know...
Protective role of autophagy in triptolide-induced apoptosis of TM3 Leydig cells [0.03%]
三氧化二砷诱导的TM3支持细胞毒性作用中自噬的保护机制研究
Xiaoyun Ye,Liang Chen
Xiaoyun Ye
Background and objectives: Triptolide (TP) is known to impair testicular development and spermatogenesis in mammals, but the mechanism of the side effects still needs to be investigated. The aim of the research is to conf...
Mini-dose methotrexate combined with methylprednisolone as a first-line treatment for acute graft-versus-host disease: A phase 2 trial [0.03%]
小剂量甲氨蝶呤联合甲基强的松治疗急性移植物抗宿主病的疗效：一项二期临床试验
Zhengli Xu,Xiaodong Mo,Yuan Kong et al.
Zhengli Xu et al.
Background and objectives: Acute graft-versus-host disease (aGvHD) remains a major complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methylprednisolone (MP; 1-2 mg/kg/day) remains the stan...