Efficacy and safety of QL0911 in adult patients with chronic primary immune thrombocytopenia: A multicenter, randomized, double-blind, placebo-controlled, phase III trial [0.03%]
QL0911在成人慢性原发免疫性血小板减少症患者中的有效性和安全性：一项多中心，随机，双盲，安慰剂对照，III期试验
Hu Zhou,Shouqing Han,Jie Jin et al.
Hu Zhou et al.
Objective: QL0911, a recombinant human thrombopoietin mimetic peptide-Fc fusion protein, is a romiplostim (Nplate®) biosimilar used to treat primary immune thrombocytopenia (ITP). This phase III study aimed to assess the...
Jiarou Li,Hongliang Wang
Jiarou Li
Autophagy is the initial defense response of the host against pathogens. Autophagy can be either non-selective or selective. It selectively targets the degradation of autophagic substrates through the sorting and transportation of autophagi...
Hypervolemia suppresses dilutional anaemic injury in a rat model of haemodilution [0.03%]
高血容量可抑制血液稀释大鼠模型中的贫血损伤
Muzaffer Utku Cakir,Berna Yavuz-Aksu,Ugur Aksu
Muzaffer Utku Cakir
Background and objectives: Haemodilution leads to complications in clinical practice. It is exactly unknown whether this damage is caused by the fluid or by the stretching of the vascular bed. We aimed to compare two diff...
Temporal trend of acute myocardial infarction-related mortality and associated racial/ethnic disparities during the omicron outbreak [0.03%]
奥密克戎疫情爆发期间急性心肌梗死相关死亡率及时空分布特征及相关种族差异研究
Yee Hui Yeo,Yue Zhang,Xinyuan He et al.
Yee Hui Yeo et al.
Timing of TIPS for the management of portal vein thrombosis in liver cirrhosis [0.03%]
肝硬化门静脉血栓形成管理中TIPS治疗的时机问题
Yong Lv,Yanglin Pan,Huahong Xie et al.
Yong Lv et al.
Cardiac magnetic resonance imaging-derived septum swing index detects pulmonary hypertension: A diagnostic study [0.03%]
由心脏磁共振影像获得的室间隔摆动指数可诊断肺动脉高压：一项诊断研究
Miao He,Rong Jiang,Fei-Sun et al.
Miao He et al.
Background and objectives: Because of pressure differences between the pulmonary artery and aorta, the ventricular septum moves in a swinging motion that is commonly observed on cardiac MR (CMR) cine sequences in patients...
Crosstalk between gut microbiota and gut resident macrophages in inflammatory bowel disease [0.03%]
肠道微生物群与常驻巨噬细胞在炎性肠病中的相互作用
Haohao Zhang,Xueying Wang,Jing Zhang et al.
Haohao Zhang et al.
Macrophages residing in the gut maintain gut homeostasis by orchestrating patho-gens and innocuous antigens. A disturbance in macrophages leads to gut inflamma-tion, causing conditions such as inflammatory bowel disease (IBD). Macrophages e...
Short-term duration of diabetic retinopathy as a predictor for development of diabetic kidney disease [0.03%]
糖尿病视网膜病变的短期持续时间作为预测糖尿病肾脏疾病的因素
Jiayu Duan,Dongwei Liu,Zihao Zhao et al.
Jiayu Duan et al.
Background: Diabetic retinopathy (DR) is a risk factor for diabetic kidney disease (DKD). Whether the duration, especially the short-term duration, of DR is associated with the development and progression of DKD remains u...
Impact of gut microbiota and associated mechanisms on postprandial glucose levels in patients with diabetes [0.03%]
肠道微生物及其相关机制对糖尿病患者餐后血糖水平的影响
Xinyuan Feng,Mingqun Deng,Lina Zhang et al.
Xinyuan Feng et al.
Diabetes and its complications are serious medical and global burdens, often manifesting as postprandial hyperglycemia. In recent years, considerable research attention has focused on relationships between the gut microbiota and circulating...