Preparing for the implementation of anti-amyloid therapies in Europe: Assessing real-world eligibility for lecanemab and donanemab in a Swedish memory clinic [0.03%]
欧洲实施抗淀粉样蛋白治疗的准备：评估瑞典记忆诊所真实世界的乐能玛和多纳玛治疗的适用性
Anna Rosenberg,Alina Solomon,Alexandre Bonnard et al.
Anna Rosenberg et al.
Lecanemab and donanemab are the first anti-Aβ treatments to receive approval in Europe. Eligibility criteria are strict, eg., APOE ε4/4 carriers are excluded. Successful implementation in public healthcare hinges on accurate estimates of ...
Cost-effectiveness analysis of blood-based biomarker testing in the diagnosis of Alzheimer's disease pathology [0.03%]
基于血液的生物标志物检测在阿尔茨海默病病理诊断中的成本效益分析
Yonghong Li,Robert J Lagier,Michael K Racke et al.
Yonghong Li et al.
Objectives: We aimed to evaluate the cost-effectiveness of blood-based biomarker (BBM) testing vs amyloid positron emission tomography (PET) in patients with signs and symptoms of cognitive decline in a neurologist/specia...
The liver as a metabolic and immune hub in Alzheimer's disease: From mechanisms to therapeutic opportunities [0.03%]
阿尔茨海默病中的肝脏：从代谢和免疫角度探讨其作用机制及治疗机会
Jiajie Chen,Luyao Wang,Yingying Zhou et al.
Jiajie Chen et al.
Research on Alzheimer's disease (AD) has traditionally focused on the brain. However, emerging evidence indicates that the liver acts as a silent partner in neurodegeneration. As a core hub for metabolic and immune regulation, the liver com...
Preeclampsia as a reversible risk factor for Alzheimer's disease: A prospective MRI study on morphological changes of the cerebral cortex and impairment of cognitive functions [0.03%]
子痫前期作为阿尔茨海默病的一种可逆的风险因素：一项关于大脑皮层形态变化及认知功能损伤的前瞻性磁共振成像研究
Yuanyuan Wang,Meng Li,Tao Chen et al.
Yuanyuan Wang et al.
Purpose: To investigate the cross-sectional and longitudinal alterations in cortical thickness and surface area and Cognitive Impairment among patients with preeclampsia. ...
Head injury/traumatic brain injury and the risk of dementia: An observational and Mendelian randomization study [0.03%]
头部受伤/创伤性脑损伤与痴呆风险的关系：一项观察研究和孟德尔随机化研究
Ziyu Ouyang,Bin Jiao,Xuewen Xiao et al.
Ziyu Ouyang et al.
Background: This study aimed to investigate the link between head injury (HI)/traumatic brain injury (TBI) and dementia risk, as it remains unclear. Metho...
Plasma Aβ42/Aβ40 determined by mass spectrometry is associated with longitudinal changes in amyloid accumulation, brain atrophy, and conversion to mild cognitive impairment due to Alzheimer's disease in individuals with subjective cognitive decline: 5-year follow-up of the FACEHBI cohort [0.03%]
基于质谱测定的血浆Aβ42/Aβ40与个体主观认知下降向轻度阿尔茨海默病痴呆转化、淀粉样蛋白积累和脑萎缩纵向变化的相关性：FACEHBI队列5年随访研究
Noelia Fandos,María Pascual-Lucas,Leticia Sarasa et al.
Noelia Fandos et al.
Background: The accurate identification of individuals at risk of Alzheimer's disease (AD) through blood-based biomarkers remains challenging. Objectives:...
Phase 3 randomized clinical trials of simufilam in mild-to-moderate Alzheimer's disease [0.03%]
司库匪拉姆治疗轻中度阿尔茨海默病三期随机临床试验
James W Kupiec,Anton P Porsteinsson,Raymond S Turner et al.
James W Kupiec et al.
Background: Soluble amyloid β1-42 (Aβ42) signals via the α7 nicotinic acetylcholine receptor to hyperphosphorylate tau in Alzheimer's disease (AD). Simufilam disrupts this pathogenic signaling by binding filamin A and ...
Hippocampal microstructure as a measure of cognitive resilience to tau PET burden in older adults [0.03%]
老年人大脑海马微结构在tau-PET负荷下的认知韧性作用的评估
Daniel D Callow,Nisha Rani,Kylie H Alm et al.
Daniel D Callow et al.
Background: Cognitive resilience, the ability to maintain better than expected cognitive function despite neuropathological burden, is a key contributor to clinical outcomes in Alzheimer's disease (AD), though the underly...
Longitudinal changes in subcortical functional connectivity during Alzheimer's disease progression [0.03%]
阿尔茨海默病进展过程中亚皮质功能连接的纵向变化
Sunghun Kim,Sewook Oh,Hyunjin Park et al.
Sunghun Kim et al.
Human cognition and behavior rely on the integration of large-scale neural networks that connect the cerebral cortex and subcortical structures. Emerging evidence suggests that alterations in the functional connectivity (FC) between the cor...
Associations of modifiable and non-modifiable risk factors with longitudinal white matter hyperintensities, amyloid-β and tau - a prospective cohort study [0.03%]
可改变和不可改变的风险因素与纵向脑白质高信号、淀粉样蛋白-β和tau的关系——前瞻性队列研究
Isabelle Glans,Niklas Mattsson-Carlgren,Olof Strandberg et al.
Isabelle Glans et al.
Background: The global prevalence of dementia is rapidly expanding and is expected to triple by 2050. Approximately 45 % of dementia cases are estimated to be attributable to potentially modifiable risk factors. Identifyi...