Association of the cumulative modified life's Essential 8 score with cognitive change: Results from two longitudinal cohorts [0.03%]
累积改良版生命八大健康指标与认知变化的关系：来自两项纵向队列研究的结果
Yiwen Dai,Yuling Liu,Yang Pan et al.
Yiwen Dai et al.
Introduction: Although a higher baseline Life's Essential 8 (LE8) score is linked to better cognitive performance and slower decline, it remains unclear whether the cumulative LE8 score is associated with cognitive change...
Screening for Alzheimer's disease in the community using an AI-driven screening platform: design of the PREDICTOM study [0.03%]
基于人工智能的痴呆筛查平台在社区中开展阿尔茨海默病早期筛查研究方案
Anna-Katharine Brem,Zunera Khan,Jonas Radermacher et al.
Anna-Katharine Brem et al.
Background: Recent developments in physiological, imaging and digital biomarkers combined with the approval of new disease-modifying drugs against Alzheimer's disease (AD) and diagnostic blood tests provide an opportunity...
Modifiable lifestyle factors for dementia risk in an online cohort assessed by the MoCA Cognitive Health Assessment Index (MoCA-CHAI) [0.03%]
在线队列中由MoCA认知健康评估指数(MoCA-CHAI)评定的痴呆风险的可改变生活方式因素
Laura Klaming,Hans-Aloys Wischmann,Murray Gillies et al.
Laura Klaming et al.
Background: The growing prevalence of dementia highlights the need for a risk assessment tool that is accessible, facilitates the identification of at-risk individuals, and provides evidence-based guidance on how to reduc...
Performance of a fully automated plasma tau phosphorylated at threonine 217 immunoassay to reflect amyloid-beta burden in an unselected cohort representative of clinical practice [0.03%]
一项在符合临床实践的非选择性受试者队列中全面自动化免疫测定血浆tau蛋白苏氨酸217磷酸化水平以反映β淀粉样蛋白负荷的性能研究
Sayuri Hortsch,Annunziata Di Domenico,Niels Borlinghaus et al.
Sayuri Hortsch et al.
Background: With the emergence of disease-modifying anti-amyloid-beta (Aβ) therapies for Alzheimer's disease (AD), early and accurate quantitative measures of Aβ burden are critical. Blood-based biomarkers are a scalabl...
Characteristics of infusion-related reactions to lecanemab in early Alzheimer's disease: A multicenter real-world study in Northwestern China [0.03%]
仑单抗治疗早期阿尔茨海默病的输液相关反应特征：中国西北多中心真实世界研究
Peijie Liu,Jie Liu,Jin Wang et al.
Peijie Liu et al.
Background: Infusion-related reactions (IRRs) represent the most common adverse events associated with lecanemab. However, real-world data on IRR characteristics and risk factors in Asian populations, particularly Chinese...
Interim analysis of all-case post-marketing surveillance study in Japan: lecanemab in patients with early Alzheimer's disease [0.03%]
仑单抗治疗早期阿尔茨海默病患者的全例事件后市场监测研究的期中分析
Atsushi Iwata,Yukinori Sakata,Kinuyo Koizumi et al.
Atsushi Iwata et al.
Background: Lecanemab is a monoclonal antibody targeting amyloid-beta protofibrils, indicated for patients with mild cognitive impairment (MCI) and mild dementia due to Alzheimer's disease. ...
Integrative SMR prioritizes oxidative stress-related regulatory genes for Alzheimer's disease with brain-tissue validation [0.03%]
整合型SMR优先选择与阿尔茨海默病有关的氧化应激相关调节基因，并通过脑组织验证其有效性
Liu Wu,Yu-Ting Dong,Xin Mu et al.
Liu Wu et al.
Oxidative stress (OS) plays a critical role in the pathogenesis of Alzheimer's disease (AD), yet its genetic and epigenetic regulatory mechanisms remain unclear. In this study, we applied a three-step summary-based Mendelian randomization (...
Evaluating evidence-based recruitment strategies for Alzheimer's disease and related dementias clinical trial research: A literature review [0.03%]
基于证据的阿尔茨海默病及相关痴呆症临床试验研究招募策略的文献回顾及评估
Mireille Jacobson,Christina Deuschle,Desi Peneva et al.
Mireille Jacobson et al.
Background: With the prevalence of Alzheimer's disease and related dementias (ADRD) rising, prevention and treatment clinical trials are increasingly important. Yet inadequate participant recruitment to ADRD research-a le...
Discordance in amyloid positivity between visual reads and Centiloids: Impact of white matter uptake [0.03%]
视觉读数和Centiloid值之间淀粉样蛋白阳性不一致：脑白质摄取的影响
Arnaud Charil,Todd M Nelson,Anthonin Reilhac et al.
Arnaud Charil et al.
Background: The visual interpretation of amyloid PET scans, or visual read (VR), is the most common technique used in clinical practice to identify the presence of cerebral amyloid plaques. Amyloid status (positive or neg...