Relative importance of blood-based biomarkers for Alzheimer's disease-specific neurodegeneration and cognitive decline [0.03%]
血液生物标志物在阿尔茨海默病特异性神经退行性病变和认知衰退中的相对重要性研究
Keun You Kim,Hyunsun Ham,Eun Jin Yoon et al.
Keun You Kim et al.
Background: Although blood-based biomarkers are now available for diagnosing Alzheimer's disease (AD), the best biomarker for AD-specific neurodegeneration and cognitive decline remains unclear. This study aimed to determ...
Can we identify people with Alzheimer's disease from examination of the eye? A bidirectional Mendelian randomization (MR) study [0.03%]
基于孟德尔随机化研究的眼部检查与阿尔茨海默病之间的关联性分析
Humayun Kiser,Ashley Budu-Aggrey,Jessica N Cooke Bailey et al.
Humayun Kiser et al.
Background: Neurodegeneration in Alzheimer's disease (AD) is thought to be driven by amyloid-beta and tau deposition in the cerebral vasculature and brain. As the eye is an extension of the central nervous system, this st...
Suboptimal adherence to brain health recommendations in patients pursuing anti-amyloid antibody therapy for Alzheimer's disease: Report from the Brain Health Vital Signs project [0.03%]
阿尔茨海默病患者在接受抗淀粉样蛋白抗体治疗时对脑健康建议的依从性较差：来自“脑健康生命体征”项目的一项研究报告
Kirk R Daffner,Kayla Riera,George R Ghorayeb et al.
Kirk R Daffner et al.
Background: Consensus is consolidating around a set of lifestyle and medical factors that can promote brain health and reduce the risk of dementia for older adults and further decline for those with early Alzheimer's dise...
Sex differences in subjective cognition among middle-aged and older Hispanic/Latino adults: Findings from the HCHS/SOL and SOL-INCA [0.03%]
中老年西班牙裔/拉丁裔成人主观认知性别差异：HCHS/SOL和SOL-INCA研究结果
Ariana M Stickel,Wassim Tarraf,Sayaka Kuwayama et al.
Ariana M Stickel et al.
Introduction: Sex differences in subjective cognitive decline (SCD) exist, yet the extent to which these differences generalize to underrepresented groups is unknown. Therefore, we investigated relationships between sex a...
MIND GamePack: A novel digital health technology for assessment of participants with and without cognitive impairment [0.03%]
适用于各类认知功能受试者的新型数字健康技术Mind Gamepack的研究与评估
Jake A Galler,Liuqing Yang,Chao-Yi Wu et al.
Jake A Galler et al.
Background: Digital biomarkers offer promising avenues for enhancing the identification, prognosis, and phenotyping of Alzheimer's Disease (AD). This study evaluates the feasibility and utility of the MIND GamePack©, a d...
Dietary patterns and Alzheimer's disease: East-west perspectives and future intervention strategies [0.03%]
饮食与阿尔茨海默病：东西方视角及未来干预策略
Wanlu Jiang,Yijia Lin,Qihao Guo et al.
Wanlu Jiang et al.
Among various modifiable risk factors, dietary patterns (DPs), as a holistic lifestyle intervention, have become a focus of current research due to their protective effects on cognitive health. Classic Western DPs, such as the Mediterranean...
Hippocampal asymmetry captures non-amyloid-related risk of memory decline and clinical progression [0.03%]
海马不对称性捕捉非淀粉样相关的记忆衰退和临床进展风险
Elham Ghanbarian,Babak Khorsand,Lukai Zheng et al.
Elham Ghanbarian et al.
Background: Hippocampal atrophy is a key marker of Alzheimer's disease (AD)- related neurodegeneration; however, hippocampal volume alone may not fully capture heterogeneity in cognitive decline. Left-right hippocampal as...
Tau-ing and fro-ing: the tanycytic shuttle in neurodegeneration [0.03%]
白质 tau 蛋白往复穿梭：神经退行性疾病中的胶质细胞シャトル现象
Vincent Prévot,Markus Schwaninger,Ruben Nogueiras et al.
Vincent Prévot et al.
After more than a century since Alzheimer's disease (AD) was described and decades of research into β-amyloid and Tau proteins, mechanisms underlying pathogenic protein clearance from brain remain poorly understood. Recent research identif...
Glymphatic dysfunction, plasma neurofilament light, and cortical free water mediate cognitive decline in familial frontotemporal lobar degeneration [0.03%]
家族性额颞叶变性中胶淋巴系统功能障碍、血浆神经丝轻链和皮质自由水介导认知衰退的作用机制
Meiling Qiu,Li Ding,Rui Bao et al.
Meiling Qiu et al.
Background: Familial frontotemporal lobar degeneration (f-FTLD) is the second most common form of young-onset dementia, with diverse clinical presentations, neuropathological substrates and genetic backgrounds. While evid...
Distinct spatial patterns of perivascular spaces enlargement for multiple and Co-existing pathologies of cognitive impairment [0.03%]
多重和共存的认知障碍病理的血管周围空间扩张的不同空间模式
Woosik Kim,Yejin Hwang,Yelim Yang et al.
Woosik Kim et al.
Background: This study examines how amyloid-β and vascular pathology independently and jointly relate to regional perivascular space (PVS) burden on T2-weighted MRI. ...