Christina S Dintica,Julia Cheunkarndee,R Nick Bryan et al.
Christina S Dintica et al.
Background: Social determinants of health (SDOH) are increasingly recognized as important drivers of cognitive outcomes. However, most existing evidence focuses on individual SDOH components and older populations. ...
Quantifying generalization error in machine learning prediction of cognitive decline [0.03%]
量化机器学习预测认知衰退的泛化误差
Roya Melanie Hüppi,Nicolas Langer,Bruno Hebling Vieira;Alzheimer’s Disease Neuroimaging Initiative
Roya Melanie Hüppi
Background: Predicting cognitive decline as a continuum, from healthy age-related decline to mild cognitive impairment and dementia, enables more precise individual-level predictions. However, the practical value of such ...
Risk of Dementia after initiation of GLP-1 RA versus long-acting insulin in patients with type 2 Diabetes mellitus [0.03%]
与长效胰岛素相比，GLP-1受体激动剂对2型糖尿病患者痴呆发生的风险
Chien-Hung Lin,Peir-Haur Hung,Mu-Chi Chung et al.
Chien-Hung Lin et al.
Background: Recent studies suggest a decreased risk of dementia in patients treated with glucagon-like peptide-1 receptor agonist (GLP-1 RA). In this study, we compare the risk of dementia associated with GLP-1 RA versus ...
Psychological adversities and epigenetic ageing in midlife and older age: A systematic review and meta-analysis [0.03%]
心理逆境与中老年人表观遗传衰老：系统评价和meta分析
Jiuyu Guo,Jiatong Shan,Kaisy Xinhong Ye et al.
Jiuyu Guo et al.
Background: Epigenetic modification is a hallmark of aging that encloses physiological information relevant to health and longevity and has been used to construct epigenetic clocks that estimate epigenetic age acceleratio...
Ron Handels,Bernhard Michalowsky,Aline Mendes et al.
Ron Handels et al.
Introduction: We aimed to estimate the cost-effectiveness of the patient-centered special care unit for behavioral and psychological symptoms of dementia (SCU-B) in the Respectful Caring for the Agitated Elderly (RECage) ...
Timing of cognitive decline onset and life-course trajectories A pooled longitudinal analysis of 14,389 adults across three cohorts [0.03%]
认知衰退的发病时间及其生命周期变化轨迹：来自三个队列的14389名成年人的合并纵向分析
Jan Sebastian Novotný,Sivan Klil-Drori,Yonas Endale Geda et al.
Jan Sebastian Novotný et al.
Background: Population ageing is driving a global surge in cognitive impairment. While late-life decline is well-characterized, the onset of measurable cognitive changes across the full adult lifespan remains uncertain. W...
Increasing cardiovascular disease risk predicts faster cognitive decline: A Bayesian analysis of a cohort of adults in rural West Texas [0.03%]
心血管疾病风险增加预示认知功能更快衰退：农村地区西得克萨斯州成年人群队列的贝叶斯分析
Chathurika S Dhanasekara,Chanaka N Kahathuduwa,Volker Neugebauer
Chathurika S Dhanasekara
Background: Cardiovascular disease (CVD) is a major risk factor for cognitive decline and dementia. We examined whether a higher atherosclerotic cardiovascular disease (ASCVD) risk is associated with faster cognitive decl...
Stages of objective memory impairment (SOMI) as a predictor of clinical progression in the A4 study [0.03%]
A4研究中客观性记忆损伤（SOMI）对临床进展的预测作用
Priyanka Kumari,Richard B Lipton,Andrew J Aschenbrenner et al.
Priyanka Kumari et al.
Background: About one third of amyloid positive, cognitively normal individuals develop mild cognitive impairment or clinical Alzheimer dementia (AD) over 5 years of follow-up. Sensitive cognitive measures, in addition to...
Relative importance of blood-based biomarkers for Alzheimer's disease-specific neurodegeneration and cognitive decline [0.03%]
血液生物标志物在阿尔茨海默病特异性神经退行性病变和认知衰退中的相对重要性研究
Keun You Kim,Hyunsun Ham,Eun Jin Yoon et al.
Keun You Kim et al.
Background: Although blood-based biomarkers are now available for diagnosing Alzheimer's disease (AD), the best biomarker for AD-specific neurodegeneration and cognitive decline remains unclear. This study aimed to determ...
Can we identify people with Alzheimer's disease from examination of the eye? A bidirectional Mendelian randomization (MR) study [0.03%]
基于孟德尔随机化研究的眼部检查与阿尔茨海默病之间的关联性分析
Humayun Kiser,Ashley Budu-Aggrey,Jessica N Cooke Bailey et al.
Humayun Kiser et al.
Background: Neurodegeneration in Alzheimer's disease (AD) is thought to be driven by amyloid-beta and tau deposition in the cerebral vasculature and brain. As the eye is an extension of the central nervous system, this st...