Structural social factors modify the association between Alzheimer's pathology and cognitive function [0.03%]
结构社会因素改变了阿尔茨海默病病理改变与认知功能之间的关系
Michelle Gerards,Lena Sannemann,Frank Jessen
Michelle Gerards
Background: Social factors have been linked to cognitive decline and risk of dementia. However, our understanding of their impact on cognition in the context of Alzheimer's disease (AD) pathology is still limited. ...
Moving toward a more rigorous science of recruitment in clinical research. Commentary on "Evaluating evidence-based recruitment strategies for Alzheimer's disease and related dementias clinical trial research: a literature review" [0.03%]
迈向临床研究招募的更严谨科学——对“阿尔茨海默病及相关痴呆症临床试验招募的证据-based策略评估：文献综述”的评论
Jaime Perales-Puchalt,Eric D Vidoni
Jaime Perales-Puchalt
Late-life body mass index and amyloid interaction on cognitive decline in unimpaired older adults [0.03%]
老年认知功能下降与β淀粉样蛋白相互作用的体重指数阈值效应研究
Wai-Ying Wendy Yau,Rema Raman,Jasmeer Chhatwal et al.
Wai-Ying Wendy Yau et al.
Background: The late-life "obesity paradox" of reduced Alzheimer's disease (AD) risk is postulated to be driven by underlying preclinical/prodromal pathology. However, few studies have directly examined the joint associat...
Amyloid-related imaging abnormalities in Japanese patients with Alzheimer's disease treated with Lecanemab: A real-world study [0.03%]
莱卡奈单抗治疗日本阿尔茨海默病患者的淀粉样蛋白相关影像学异常的一项真实世界研究
Ryosuke Shimasaki,Masanori Kurihara,Taro Bannai et al.
Ryosuke Shimasaki et al.
Background: Although clinical trials have suggested a lower incidence of adverse events associated with Lecanemab in Asian populations compared to global cohorts, longitudinal real-world data across broader clinical indic...
Barriers and facilitators to recruitment, engagement, and retention of underrepresented populations in dementia prevention research: a scoping review [0.03%]
痴呆症预防研究中被边缘化人群招募、参与和保留的障碍与促进因素：系统综述
A F Rirash,S Franzen,R Bourdage et al.
A F Rirash et al.
Underrepresented populations in dementia prevention research, including minoritized racial/ethnic groups, individuals with lower socioeconomic status, and others facing social and structural disadvantages, are disproportionately affected by...
Global, regional, and national burden of dementia attributable to mood disorders: a comparative risk assessment study [0.03%]
全球、区域和国家因心境障碍导致的痴呆负担归因于情绪障碍的痴呆疾病负担的全球、区域和国家比较风险评估研究
Jing Wu,Jiali Zhou,Shiyi Shan et al.
Jing Wu et al.
Background: Mood disorders, particularly depressive and bipolar disorders, have emerged as potentially modifiable risk factors for dementia. However, the burden of dementia attributable to mood disorders remains unquantif...
Dementia risk factor assessment in a local Alzheimer's prevention population: a German cross-sectional, observational study [0.03%]
德国一项关于阿尔茨海默病预防人群痴呆风险因素的评估研究
Lena Sannemann,Michelle Gerards,Lara Bohr et al.
Lena Sannemann et al.
Background: The risk for dementia is to a significant extent driven by potentially modifiable factors. Prevention strategies are increasingly aiming at individually tailored risk reduction approaches, particularly in ligh...
Increase in healthcare utilization and Medicare payment with progression of preclinical Alzheimer's disease [0.03%]
未确诊阿尔茨海默病病情进展与医疗保健利用率和医疗保险支付的关系增强
Julie Beyrer,Zachary Sheff,Nalin Payakachat et al.
Julie Beyrer et al.
Background: Alzheimer's disease (AD) begins with the preclinical stage (Stages 1 and 2) where individuals are cognitively unimpaired but have AD pathology. Healthcare utilization and medical cost of cognitively unimpaired...
Right-lateralized cerebellar cortical thickening is associated with mild behavioral impairment in mild cognitive impairment [0.03%]
轻度认知障碍患者轻度行为异常与右侧小脑皮层增厚有关
Sohee Kim,Young-Chul Jung,Eosu Kim et al.
Sohee Kim et al.
Background: Mild Behavioral Impairment (MBI) reflects later-life emergence of persistent neuropsychiatric symptoms and is increasingly recognized as an early manifestation of neurodegenerative disease, yet cerebellar corr...
Plasma GFAP outperforms CSF GFAP in detecting amyloid pathology and is associated with increased risk of clinical progression in early Alzheimer's disease [0.03%]
血浆GFAP优于脑脊液GFAP，可检测淀粉样蛋白病理，并与早期阿尔茨海默病临床进展风险增加相关
Arda C Cetindag,Carola G Schipke,Hermann Esselmann et al.
Arda C Cetindag et al.
Background: Early and accurate detection of Alzheimer's disease (AD) is essential for timely intervention and development of disease-modifying treatments. The DZNE-Longitudinal Cognitive Impairment and Dementia Study (DEL...