Speech-based digital biomarkers for early etiological stratification of Alzheimer's disease and frontotemporal degeneration: a biomarker-confirmed prospective study [0.03%]
基于语音的数字生物标志物在阿尔茨海默病和额颞叶变性早期病因分层中的应用：一项经生物标志物确认的前瞻性研究
Eloïse Da Cunha,Valeria Manera,Frédéric Chorin et al.
Eloïse Da Cunha et al.
Background: Early differentiation between Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD) is a prerequisite for secondary prevention and targeted trial enrollment, yet remains challenging at disease ...
Assessment of clinical and neuroimaging efficacy of treatment targeting tau pathology in mild cognitive impairment and mild to moderate Alzheimer's disease with hydromethylthionine mesylate using external control data [0.03%]
使用外部对照数据评估轻度认知障碍和轻中度阿尔茨海默病患者使用盐酸羟甲甲基硫离子针对tau病理治疗的临床和神经影像疗效评估
Bjoern O Schelter,Helen Shiells,Serena Lo et al.
Bjoern O Schelter et al.
Background: Hydromethylthionine mesylate (HMTM) targets tau pathology and also has tau-independent symptomatic activity. A traditional randomised placebo-controlled trial (RCT) was precluded by loss of blinding due to uri...
The concurrent burden of Alzheimer's pathology, cerebral amyloid angiopathy, and microinfarcts on cognitive decline [0.03%]
阿尔茨海默病病理、脑淀粉样血管病和微梗死对认知衰退的协同影响
Mingyao You,Chao Tang,Lianfei Liu et al.
Mingyao You et al.
Background: Alzheimer's disease (AD) is frequently complicated by vascular co-morbidities. However, the specific mechanistic pathways by which vascular lesions interact with genetic susceptibility to accelerate cognitive ...
Pathways to participation - a scoping review outlining barriers and enablers to participation in dementia research [0.03%]
参与痴呆症研究的途径-概述参与障碍和促进因素的综述性评论文章
Lukas A Duffner,Soraya Moradi-Bachiller,Dianne Gove et al.
Lukas A Duffner et al.
Background: Ongoing participant recruitment challenges in dementia research highlight the need to understand public perspectives on research participation. This scoping review explored existing literature on barriers and ...
Hypolipidemics reduce the rate of Alzheimer's disease development and dementia progression: A cohort study linked with genetic and neuropathological analyses [0.03%]
降脂药减缓阿尔茨海默病的发生和发展速度及痴呆的进展：一项与遗传学和神经病理学分析相联系的队列研究
Zohi Sternberg,Rebecca E Podolsky,Jihnhee Yu et al.
Zohi Sternberg et al.
Background: High cholesterol contributes to the development and progression of dementia due to both Alzheimer's disease (A.D.) and vascular pathology. However, the effects of lipid-lowering regimen (LLR) on cognitive dysf...
ATNIVS biomarker heterogeneity in real-world patients receiving lecanemab [0.03%]
接受莱卡单抗治疗的现实世界患者的ATN和Cerebrovascular淀粉样蛋白生物标志物异质性
Masanori Kurihara,Ryoko Ihara,Gen Yoshii et al.
Masanori Kurihara et al.
Background: While amyloid-β (Aβ) biomarker positivity is sufficient before initiating anti-Aβ antibody therapy, recent revised criteria also highlight the importance of other biomarkers (ATNIVS) to understand heterogen...
Gregory Cooper
Gregory Cooper
Comparative effects of some pharmacological and non-pharmacological interventions on cognitive function in Alzheimer's disease: A Bayesian network meta-analysis [0.03%]
阿尔茨海默病认知功能的药理学和非药理学干预效果的网状meta分析研究
Yuning Zhao,Guangxin Luo,Can Huang et al.
Yuning Zhao et al.
Background: Given the growing global public health burden of Alzheimer's disease, this study used the Bayesian network meta-analysis to assess the effects of pharmacological and non-pharmacological interventions on cognit...
Multidimensional modeling of biological aging: integrating gait, eye movement, rest-state functional connectivity, and plasma biomarkers in non-dementia older adults [0.03%]
多维度建模生物学老化：在非痴呆老年人中整合步态、眼动、静息态功能连接和血浆生物标志物
Jingyi Lin,Yiliang Liu,Ziyu Ouyang et al.
Jingyi Lin et al.
Accurate modeling of biological age has clinical value for risk stratification, personalized prevention, and intervention planning, promoting proactive healthcare for aging and age-related diseases. Because aging is multidimensional, robust...
Knowledge and perception of dementia risk and protective factors: a systematic review and meta-analysis [0.03%]
痴呆风险和保护因素的知识与认知：系统评价和meta分析
Muhammed L Sambou,Jolanda H M Dobbe,Elaine A C Albers et al.
Muhammed L Sambou et al.
Background: Optimal dementia risk reduction strategies benefit from sufficient public knowledge of risk factors and risk perception, but current public awareness is uncertain. ...