Neuronal autoantibodies in neurodegenerative dementia: From evidence to clinical framework [0.03%]
神经元自身抗体在神经退行性痴呆中的作用：从证据到临床框架
Heya Luan,Xiaodong Han,Chang Xu et al.
Heya Luan et al.
Neuronal autoantibodies, including against neuronal surface receptors or intracellular antigens, are established pathogenic mediators and therapeutic targets in autoimmune encephalitis (AIE) and paraneoplastic neurological syndromes (PNS). ...
Memory Consolidation and ARIA in Individuals Receiving Anti-amyloid Monoclonal Antibodies [0.03%]
抗淀粉样蛋白单克隆抗体受试者的记忆巩固和ARIA现象
Marc W Haut,Camila Vieira Ligo Teixeira,Patrick D Worhunsky et al.
Marc W Haut et al.
Amyloid related imaging abnormalities (ARIA) are the most significant risk associated with the use of anti-amyloid monoclonal antibodies (MAB) for Alzheimer's disease (AD). Currently, the presence of the APOE ε4 allele is the best predicto...
Visuospatial memory deficit, plasma p-tau217, and Aβ42/Aβ40 ratio enhance sensitivity to identify Aβ PET positivity in individuals with SCD [0.03%]
视空间记忆障碍、血浆p-tau217和Aβ42/Aβ40比值增强敏感性以识别具有SCD个体的淀粉样蛋白PET阳性结果
Qinjie Li,Lin Huang,Ying Wang et al.
Qinjie Li et al.
Introduction: We hypothesize that specific cognitive assessments and plasma biomarkers may exhibit heightened sensitivity during the stage of subjective cognitive decline (SCD). The integration of these plasma biomarkers ...
Prevention of dementia using mobile phone applications (PRODEMOS) - a health-economic cost-utility analysis in people aged 55-75 years with low socio-economic status [0.03%]
利用手机应用程序预防低社会经济状态的55-75岁人群痴呆症（PRODEMOS）——成本效用分析
Ron Handels,Marieke Hoevenaar-Blom,Manshu Song et al.
Ron Handels et al.
Introduction: We aimed to explore the potential incremental cost-effectiveness of the PRODEMOS coach-supported mobile health intervention for primary prevention of dementia versus standard of care provided to people aged ...
Sociodemographic differences in dementia prevention knowledge in Germany: Implications for targeted health communication [0.03%]
德国痴呆症预防知识的社会人口学差异：针对健康传播的启示
Pauline Albus,Ann-Kristin Folkerts,Josef Kessler et al.
Pauline Albus et al.
Background: Dementia is a leading cause of disability and mortality worldwide. While the disorder is widely recognized, public awareness of modifiable risk and potentially protective factors remains limited. This is despi...
Diagnostic and prognostic utility of serum β-synuclein in Alzheimer's disease: a longitudinal cohort study [0.03%]
阿尔茨海默病血清β-突触核蛋白诊断和预后价值的纵向队列研究
Siqi Xie,Yumei Liang,Ting Yang et al.
Siqi Xie et al.
Background: Serum β-synuclein is an emerging blood-based biomarker for synaptic integrity in Alzheimer's disease (AD). However, its comparative performance against the established CSF marker neurogranin and its prognosti...
Longitudinal subcortical volume changes and their correlations with multiple PET and fluid biomarkers in dominantly inherited Alzheimer's disease [0.03%]
早老素基因突变型阿尔茨海默病患者脑内亚皮层结构纵向体积变化及其与多种PET和CSF标志物的相关性分析
Il Han Choo,Hoyoung Park,Brian A Gordon et al.
Il Han Choo et al.
Background: Alzheimer's disease postmortem studies demonstrate that amyloid plaques and neurofibrillary tangles are present in subcortical regions. Object...
Associations between plant-based dietary patterns and risks of cognitive impairment and dementia: A systematic review and dose-response meta-analysis [0.03%]
基于植物的膳食模式与认知功能障碍和痴呆风险关联的系统评价和剂量-反应meta分析
Jui-Hsiu Tsai,Tou-Yuan Tsai,Hua Li et al.
Jui-Hsiu Tsai et al.
Background: Evidence remains inconclusive regarding plant-based diets preventing cognitive impairment and dementia, as certain plant-based foods, including refined carbohydrates, sweets, sugar-sweetened beverages, and tra...
Lifestyle factors and DNA methylation-based aging clocks: cross-sectional and longitudinal associations in the Singapore diet and healthy aging cohort [0.03%]
生活方式因素与基于DNA甲基化的衰老时钟：新加坡饮食与健康老龄化队列的横断面和纵向关联
Jiatong Shan,Jian Hua Tay,Kaisy Xinhong Ye et al.
Jiatong Shan et al.
Background: Lifestyle factors play a critical role in healthy aging, yet their relationships with aging biomarkers remain insufficiently characterized, particularly in Asian populations. This study aimed to examine the cr...
Remote outcome measures in Alzheimer's disease clinical trials: A call to action [0.03%]
阿尔茨海默病临床试验中的远程结果评估指标：行动呼吁
Gustavo A Jimenez-Maggiora
Gustavo A Jimenez-Maggiora