Multimodal biomarker characterization of amnestic objective subtle cognitive decline in aging and preclinical Alzheimer's disease [0.03%]
多模式生物标志物表征老化和阿尔茨海默病前临床阶段的遗忘性客观轻微认知下降
David López-Martos,Raffaele Cacciaglia,Marc Suárez-Calvet et al.
David López-Martos et al.
Background: The objective of this study was to provide a multimodal biomarker characterization of amnestic objective subtle cognitive decline (obj-SCD) in aging and preclinical Alzheimer's disease (AD). ...
Combined effect of anxiety disorder and insomnia on the risk of incident ADRD diagnosis [0.03%]
焦虑障碍和失眠对继发痴呆症风险的联合影响
SangNam Ahn,Joanne Salas,Jinmyoung Cho et al.
SangNam Ahn et al.
Background: Anxiety disorders and insomnia are common modifiable conditions in older adults, but their independent and combined effects on the risk of incident Alzheimer's disease and related dementias (ADRD) remain uncle...
Diagnostic performance of an automated plasma p-tau217 chemiluminescent assay for detecting Aβ pathology in a Chinese memory clinic cohort [0.03%]
全自动血浆p-tau217化学发光检测法在中国记忆诊所队列中检测淀粉样蛋白病理的诊断性能评估
Shuai Chen,Feng-Yu Wang,Rong Li et al.
Shuai Chen et al.
Background: Blood-based biomarkers have emerged as promising tools for detecting Alzheimer's disease (AD) pathology, but validation of automated plasma assays in Chinese clinical populations remains limited. This study ev...
The growing burden of dementia in Asia: Comparative insights from Japan, China, and India [0.03%]
亚洲痴呆症负担的增长：来自日本、中国和印度的比较见解
Chen Zhang,Xuhui Chen,Yongan Sun
Chen Zhang
Background: Alzheimer's disease and other dementias (ADODs) are increasingly becoming a major public health concern in rapidly ageing Asia. We compared the disease burden across Japan, China, and India at different demogr...
Plasma brain-derived p-Tau217 outperforms other p-Tau species in detecting abnormal brain amyloid in an Asian cohort of older people with cerebrovascular disease burden [0.03%]
血脑屏障受损的老年人群中，血液磷酸化tau蛋白p-Tau217检测异常β淀粉样蛋白病理的价值高于其他p-Tau形式
Joyce R Chong,Saima Hilal,Narayanaswamy Venketasubramanian et al.
Joyce R Chong et al.
Background: Plasma brain derived-p-Tau217 (BD-p-Tau217) may outperform total-p-Tau217 in detecting brain amyloid burden and warrants evaluation. Objective...
Subjective cognition trajectories, Alzheimer biomarkers, and incident mild cognitive impairment [0.03%]
主观认知轨迹、阿尔茨海默病生物标志物及轻度认知障碍的新发风险
Elizabeth Kuhn,Luca Kleineidam,Melina Stark et al.
Elizabeth Kuhn et al.
Background: Subjective cognitive decline is common in older adults and may represent an early clinical signal along the Alzheimer's disease continuum. The clinical relevance of longitudinal changes in subjective cognitive...
Mapping the nature, type, and association network of safety incidents among individuals with cognitive impairment in China: a large-scale multicenter cross-sectional study [0.03%]
中国认知障碍人群安全事件的性质、类型及关联网络的大规模多中心横断面研究地图
Ying Zhou,Guoping Peng,Zhengluan Liao et al.
Ying Zhou et al.
Background: Patient safety critically influences both quality of life and disease progression in older adults with cognitive impairment, yet large-scale multicenter data remain scarce. This study aims to systematically an...
Efficacy and safety of donanemab in the European eligible population: TRAILBLAZER-ALZ 2 post-hoc analyses [0.03%]
多纳单抗在欧洲符合条件人群中的有效性和安全性：TRAILBLAZER-ALZ 2事后分析
Frank Jessen,Grazia Dell&#x;Agnello,Jennifer A Zimmer et al.
Frank Jessen et al.
Background: In the European Union (EU), donanemab is indicated in adults with early symptomatic Alzheimer's disease who are apolipoprotein E ε4 non-carriers or heterozygotes. Among these, patients without superficial sid...
Association between obstructive sleep apnea severity and glymphatic-related DTI-ALPS alterations in newly diagnosed, Drug-Naïve Alzheimer's disease [0.03%]
阻塞型睡眠呼吸暂停与新诊断未用药阿尔茨海默病患者脑淋巴系统相关弥散张量成像异常之间的关系
Wenxue Zheng,Yao Zhou,Yurui Xia et al.
Wenxue Zheng et al.
Background: Obstructive sleep apnea (OSA) is highly prevalent in Alzheimer's disease (AD) patients and is associated with cognitive decline. However, the mechanisms linking OSA to Alzheimer's pathophysiology, especially r...
Hypertension acts together with Aβ pathology in late-life to promote memory loss [0.03%]
高血压通过与淀粉样蛋白病理相互作用在晚年内促进记忆力下降
Lucas U Da Ros,João Pedro Ferrari-Souza,Marco Antônio de Bastiani et al.
Lucas U Da Ros et al.
Midlife hypertension (HTN) contributes to cognitive decline in Alzheimer's disease (AD). However, the exact effect of late-life HTN on the AD pathology and on cognitive decline is still controversial. Here, we aimed to assess the impact of ...