Nanotechnology in Skin Cancer Therapy: Recent Progress in Targeted Delivery [0.03%]
纳米技术在皮肤癌治疗中的应用：靶向递送的近期进展
Huang-Ping Yu,Ching-Yun Hsu,Jia-You Fang et al.
Huang-Ping Yu et al.
Skin cancer, encompassing melanoma and non-melanoma types, remains a significant public health concern globally. Conventional therapies-such as surgery, radiotherapy, chemotherapy, and immunotherapy-are constrained by poor skin penetration,...
Sacubitril/Valsartan Ameliorates Inflammation and Oxidative Stress in Hypertensive Heart Disease by Upregulating CAMKK2 Protein and Modulating the AMPK/AKT/GSK-3β Axis [0.03%]
通过上调CAMKK2蛋白和调节AMPK/AKT/GSK-3β信号轴改善高血压心脏病炎症和氧化应激的作用机制研究 Sacubitril/valsartan有望成为治疗高血压心脏病的新药
Yan-Jun Yang,Jiu-Sheng Li
Yan-Jun Yang
Sacubitril/valsartan (Sac/Val) has emerged as an effective compound with myocardium-protective functions in experimental and clinical trials for heart failure. This study investigated the function of Sac/Val in hypertensive heart disease (H...
Usefulness of Gamma-Glutamyl Transferase and Sequential Carbohydrate-Deficient Transferrin for Unhealthy Alcohol Use Screening in Indigenous Communities [0.03%]
γ-谷氨酰转肽酶和顺序性 transferrin N-乙酰葡萄糖胺缺乏物在原住民社区不健康饮酒筛查中的作用
Jing-Houng Wang,Hui-Min Tien,Hsiao-Chu Lien et al.
Jing-Houng Wang et al.
Unhealthy alcohol use (UAU) screening facilitates identification of patients with alcohol use problems for intervention. This study evaluates the usefulness of gamma-glutamyl transferase (GGT) and sequential percentage of carbohydrate-defic...
UBE3A Inhibits Trophoblast Cell Migration and Invasion by Promoting ITGB1 Degradation and Affecting PI3K/AKT Signaling [0.03%]
UBE3A通过促进ITGB1降解并影响PI3K/AKT信号通路抑制胎盘细胞迁移和侵袭
Xiu-Jun Li,Ning Wang,Fan Jiang et al.
Xiu-Jun Li et al.
Preeclampsia (PE) is an obstetric disease that is characterized by reduced migration and invasion of placental trophoblast cells. Here, the effects of the E3 ubiquitin ligase UBE3A on the migration and invasion of trophoblast cells were eva...
lncRNA LINC00958 Activates NOTCH3 by Competitively Inhibiting miR-129-2-3p to Exacerbate the Malignant Biological Behaviors of Endometrial Cancer Cells [0.03%]
长链非编码RNA LINC00958通过竞争性抑制miR-129-2-3p激活NOTCH3以促进子宫内膜癌细胞恶性生物学行为恶化
Xia Hong,Su-Li He
Xia Hong
Endometrial cancer (EC) is one of the most prevalent gynecologic malignancies, with increasing incidence worldwide. Recent studies have highlighted the critical roles of long noncoding RNAs (lncRNAs) in regulating tumor progression. This st...
Impact of Denosumab Adherence on Renal Function and Mortality Rates in Type 2 Diabetes Patients With Osteoporosis [0.03%]
二型糖尿病伴骨质疏松患者中地舒单抗依从性对肾功能及死亡率的影响
Yu-Chuan Chang,Jian-Chih Chen,Sung-Yen Lin et al.
Yu-Chuan Chang et al.
Type 2 diabetes mellitus (T2DM) is associated with an increased risk of osteoporosis and fractures, and denosumab, a non-kidney-excreted antiresorptive medication, represents a viable alternative to bisphosphonates for osteoporosis treatmen...
Acute Effects of the 5-Hydroxytryptamine Type 4 Receptor Agonist Mosapride on Pharyngeal Swallowing Physiology in Adults [0.03%]
5-羟色胺受体激动剂莫沙必利对成人吞咽生理的急性影响
Shu-Wei Liang,Jui-Sheng Hung,Taher Omari et al.
Shu-Wei Liang et al.
The 5-hydroxytryptamine type 4 receptor agonist mosapride is known to modulate esophageal peristalsis and enhance lower esophageal sphincter compliance. However, its impact on oropharyngeal swallowing physiology remains insufficiently chara...
Kaempferitrin's Dual Assault: Inducing Apoptosis and Ferroptosis in Diffuse Large B-Cell Lymphoma via NF-κB Inactivation [0.03%]
羌姜素通过NF-κB失活诱导弥漫性大B细胞淋巴瘤凋亡和铁死亡的双重攻击
Han-Shuo Zhang,Xiao-Dan Zhou,Jin Chen et al.
Han-Shuo Zhang et al.
Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma and is an aggressive and highly heterogeneous tumor. Kaempferitrin (KPF) is a natural flavonoid glycoside that exerts a protective role in multiple human tumors. ...
Human Breast Milk-Derived Exosomal FP671120.4 Inhibits Macrophage M1 Polarization via Modulating the ELAVL1/Nrf2 Axis in Sepsis-Associated Liver Injury [0.03%]
人乳外泌体FP671120.4通过调节ELAVL1/Nrf2轴抑制脓毒症相关性肝损伤中M1型巨噬细胞极化
Zhao-Bin Yang,Yi-Bin Gao,Xiao-Mei Cheng et al.
Zhao-Bin Yang et al.
Sepsis-associated liver injury (SALI) plays a major role in aggravating disease progression and worsening prognosis in patients with sepsis. Macrophage polarization is a key factor in the modulation of SALI progression. Recent studies have ...
Impact of Time Since Diagnosis and Age on Fracture Risk in Young Adults With Type 1 and Type 2 Diabetes [0.03%]
糖尿病诊断时间及年龄对青年患者骨折风险的影响
Tien-Ching Lee,Sung-Yen Lin,Chung-Hwan Chen et al.
Tien-Ching Lee et al.