A Simplified Risk Assessment Tool to Predict Post Deceased Donor Liver Transplantation Outcomes: A Single, Highly Experienced Medical Center in Taiwan [0.03%]
一个简化 deceased 供肝移植术后预后评估模型及其外部验证
Jie-Lan Jhang,Hao-Chien Hung,Yin Lai et al.
Jie-Lan Jhang et al.
Liver transplantation (LT) is the standard treatment for end-stage liver disease, yet the gap between the demand for organs and their availability is widening. In Taiwan, the scarcity of deceased donor organs highlights the need for optimiz...
MiR-145-5p Attenuates Doxorubicin-Induced Heart Injury Through Targeting Cardiomyocyte Pyroptosis [0.03%]
miR-145-5p通过靶向心肌细胞pyroptosis减轻阿霉素诱导的心脏损伤
Xing-Tao Chen,Yong-Hong Yu,Yan-Hua Du et al.
Xing-Tao Chen et al.
Doxorubicin (DOX), a potent anthracycline chemotherapeutic, exhibits dose-dependent cardiotoxicity that limits its clinical utility. Although miR-145-5p demonstrates cardioprotective properties in cardiovascular diseases, its role in DOX-in...
Role of COL1A1 and CD44 in Modulating JAK1/STAT3-Mediated Autophagy for Spinal Cord Injury Recovery [0.03%]
COL1A1和CD44通过调节JAK1/STAT3介导的自噬在脊髓损伤修复中的作用
Chun-Lei Li,Qian Zhang,Li Fang et al.
Chun-Lei Li et al.
Spinal cord injury (SCI) is a severe trauma to the central nervous system that often leads to motor and sensory dysfunction in patients, severely affecting their quality of life. Autophagy plays a role in the pathological process of SCI, bu...
Effects of Changes in Metabolic Syndrome Status on Cognitive Function: A 10-Year Study in a Middle-Aged Population [0.03%]
代谢综合征变化对认知功能的影响：一项针对中年人群的十年研究
Kelly Lim,Meng-Ni Wu,Wei-Chia Tsao et al.
Kelly Lim et al.
The long-term cumulative impact of metabolic syndrome (MS) on cognitive decline remains uncertain. This study investigated how changes in MS status over 10 years relate to cognition and whether sex modifies this relationship. A total of 766...
Melatonin Exerts Chondroprotective Effects Against Osteoarthritis by Promoting PI3K/AKT/FoxO3-Mediated Mitophagy [0.03%]
褪黑素通过促进PI3K / AKT / FoxO3介导的线粒体自噬对骨关节炎发挥软骨保护作用
Chao Huang,Gang Zhang,Ying-Kai Ma et al.
Chao Huang et al.
Osteoarthritis (OA) is a prevalent degenerative joint disease. This study combines bioinformatics analysis with in vivo and in vitro experiments to elucidate the molecular mechanisms through which melatonin (MT) regulates mitophagy to allev...
Comparative Study of Accommodative Function and Binocular Vision in Patients With Primary Angle-Closure Disease [0.03%]
原发性闭角型疾病患者的调节功能和双眼视功能的比较研究
Feng-Rui Yang,Zhi-Qiao Liang,Ye Lu et al.
Feng-Rui Yang et al.
The age-related decline in accommodative function after the age of 50 years corresponds with an increasing incidence of primary angle-closure disease (PACD); however, the interaction between this decline and PACD remains unexamined. Additio...
Deubiquitinase USP7 Regulates Neutrophil Extracellular Trap Formation and Inflammation in Lipopolysaccharide-Treated Mice Through ICAM-1 Expression [0.03%]
巨噬细胞中的去泛素酶USP7通过调节ICAM-1表达调控脂多糖诱导的小鼠中性粒细胞胞外陷阱形成及炎症反应
Hui Xu,Qi Wang,Jing-Xian Fan et al.
Hui Xu et al.
Sepsis is typified by organ failure due to an unchecked host reaction to infection. This study aims to explore the mechanism of ubiquitin-specific peptidase 7 (USP7) in sepsis with the involvement of intercellular adhesion molecule-1 (ICAM-...
miR-127-3p Inhibits Cell Stemness and Docetaxel Resistance in Triple-Negative Breast Cancer by Targeting KIF3B [0.03%]
microRNA-127-3p通过靶向KIF3B抑制三阴性乳腺癌细胞干性和多西他赛耐药性
Zi-Chao He,Jun-Jie Zhao,Ting Yan
Zi-Chao He
This study investigated the mechanism of miR-127-3p in tumor cell stemness and docetaxel (DTX) resistance in triple-negative breast cancer (TNBC). hsa-miR-127-3p and KIF3B levels were predicted using databases and validated in TNBC and para...
Oxymatrine Inhibits Epithelial-Mesenchymal Transition to Alleviate Airway Remodeling in Chronic Obstructive Pulmonary Disease by Suppressing the TGF-β1/Smad Pathway [0.03%]
氧化可待因通过抑制TGF-β1/Smad途径缓解慢性阻塞性肺疾病气道重塑中的上皮间质转化
Shuang Zhou,Ju-Xiang Zhu,Jing Li
Shuang Zhou
This study explored the therapeutic efficacy of oxymatrine (OMT, C15H24N2O2) in a murine model of cigarette smoke (CS)-induced chronic obstructive pulmonary disease (COPD) and elucidated its underlying mechanisms. A COPD model was establish...
Fatal Pembrolizumab-Induced Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis in a Patient With Advanced Lung Adenocarcinoma [0.03%]
一例派姆单抗致重症多形红斑/中毒性表皮坏死松解症的致命不良反应报告：一项针对晚期肺腺癌患者的病例研究
Po-Chih Chang,Ting-Wei Chang,Chia-Yu Kuo et al.
Po-Chih Chang et al.