GLIS2 Promotes Epithelial-Mesenchymal Transition and Gastric Cancer Progression by Regulating BGN to Activate the Wnt/β-Catenin Pathway [0.03%]
GLIS2通过调节BGN激活Wnt/β-catenin信号通路促进胃癌上皮间质转化及进展
Juan Yan,Ya-Peng Deng
Juan Yan
This study elucidates the mechanism by which GLIS Family Zinc Finger 2 (GLIS2) promotes epithelial-mesenchymal transition (EMT) in gastric cancer through biglycan (BGN) activation and Wnt/β-catenin stimulation. By analyzing 18 pairs of GC ...
Glutamate Exacerbates Traumatic Brain Injury-Induced Acute Lung Injury Through NMDAR/ROS/Ca2+ Signaling Pathway in Pulmonary Endothelial Cells [0.03%]
谷氨酸通过肺内皮细胞NMDAR/ROS/Ca2+信号通路加重创伤性脑损伤诱导的急性肺损伤
Song Zhou,Ying-Ying Lou,Xue-Zhen Ying
Song Zhou
Traumatic brain injury (TBI) causes a high level of blood glutamate, which triggers host defense by activating oxidative stress and inflammation response. However, the concrete mechanism underlying its exacerbating effects on acute lung inj...
RBM15 Mediated m6A Modification of SRSF1 Inhibits Cuproptosis in Non-Small Cell Lung Cancer by Mediating ATP7B Alternative Splicing [0.03%]
RBM15介导的SRSF1去甲基化修饰通过调控ATP7B可变剪接抑制非小细胞肺癌铜死亡发生
Shan-Shan Mao,Dong-Yu Wu,Rong-Hua Cui et al.
Shan-Shan Mao et al.
Inhibition of cuproptosis contributes to the development of non-small cell lung cancer (NSCLC). The expression of RNA-binding motif protein 15 (RBM15) is upregulated in NSCLC. Nonetheless, its relationship with cuproptosis remains unclear. ...
The Proteomic Profiling of Circulating Extracellular Vesicles of Western Diet and Chemical-Induced Murine MASH Model [0.03%]
西方饮食和化学诱导小鼠MASH模型循环外泌体蛋白质组分析
Szu-Jen Wang,Yung-Ho Wang,Jee-Fu Huang et al.
Szu-Jen Wang et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is an increasingly prevalent chronic liver condition that can progress to severe complications such as metabolic dysfunction-associated steatohepatitis (MASH). Despite its gro...
Rosuvastatin Upregulates RCOR1 to Repress C10ORF10 Transcription and Alleviate Oxidative Stress and Plaque Formation in Atherosclerosis [0.03%]
rosuvastatin通过上调RCOR1抑制C10ORF10转录从而缓解氧化应激和动脉粥样硬化斑块形成
Xin Fu,Chuang Liu,Ya-Li Chen et al.
Xin Fu et al.
Rosuvastatin (RVS) is an HMG-CoA reductase inhibitor with lipid-lowering properties. This study aims to investigate the role of RVS in plaque formation in atherosclerosis (AS) and its functional mechanism. ApoE-/- mice were fed a high-fat d...
Hypoxia Triggers ALYREF-Mediated m5C Methylation of KIF20A to Activate KIF20A/BUB1 for Generating Ferroptosis Resistance in Cervical Cancer Cells [0.03%]
低氧通过ALYREF介导的KIF20A m5C甲基化激活KIF20A/BUB1产生宫颈癌细胞铁死亡抵抗性
Yan Gao,Ting Zou
Yan Gao
Ferroptosis resistance is a key player in cervical cancer (CC) development. Hypoxia is a negative factor affecting CC treatment by inducing ferroptosis resistance. Our study aimed to investigate the detailed mechanisms of hypoxia-induced fe...
Exercise Capacity and Pulmonary Function in Pediatric Patients With Anomalous Pulmonary Venous Connection Post-Surgical Repair: A Retrospective Analysis [0.03%]
手术矫正后异常肺静脉连接患儿运动能力和肺功能的回顾性分析
Yen-Hsien Wu,Yen-Sen Lu,Sheng-Hui Tuan et al.
Yen-Hsien Wu et al.
Anomalous pulmonary venous connection (APVC), including total (TAPVC) and partial (PAPVC) forms, is a congenital heart defect with abnormal pulmonary vein drainage; and while surgical repair has improved survival, its long-term impact on ca...
Impact of Depth of Invasion in Node-Negative Oral Tongue Cancer Treated With Surgery Alone [0.03%]
单侧舌癌手术治疗的淋巴结阴性患者的侵袭深度的影响
Po-Wen Hsiao,Yu-Tsai Lin,Hui-Ching Chuang et al.
Po-Wen Hsiao et al.
Oral tongue squamous cell carcinoma (OTSCC) is an aggressive malignancy and the most common subsite of head and neck cancer among Taiwanese males. This study aimed to evaluate the prognostic significance of depth of invasion (DOI) in patien...
MYB Activates the Hedgehog Signaling Pathway to Repress Natural Killer Cytotoxicity in Cervical Cancer [0.03%]
MYB通过激活 Hedgehog 信号通路抑制宫颈癌中的自然杀伤细胞毒性作用
Yu Wang,Chen Li
Yu Wang
Natural killer (NK) cells present in the tumor microenvironment serve as a critical line of defense against various malignancies, including cervical cancer. While MYB is known to drive malignancy progression, its influence on NK cell activi...
Impact of Add-On Hepatobiliary Abbreviated Magnetic Resonance Imaging on Ultrasound Hepatoma Surveillance for Liver Cirrhosis- a Randomized Study [0.03%]
附加肝胆简短磁共振成像对肝硬化患者超声肝癌筛查的影响：一项随机研究
Jing-Houng Wang,Hsin-You Ou,Yi-Hao Yen et al.
Jing-Houng Wang et al.
Hepatocellular carcinoma (HCC) surveillance with semi-annual ultrasound (US) is recommended for high-risk patients. This study investigates the impact of hepatobiliary abbreviated magnetic resonance imaging (AMRI) performed annually on the ...