A Practical Guide to Developing and Troubleshooting Patient-Derived "Mini-Gut" Colorectal Organoids for Clinical Research [0.03%]
临床研究中开发和排障患者衍生的“迷你肠”结直肠器官体实用指南
Rex Devasahayam Arokia Balaya,Zahra Heydari,Gobinda Sarkar et al.
Rex Devasahayam Arokia Balaya et al.
Patient-derived organoids (PDOs) have emerged as powerful tools in personalized medicine applicable to both non-malignant conditions and to cancer, where they are increasingly used for personalized drug screening and precision treatment str...
Indicator Tubes: A Novel Solution for Monitoring Temperature Excursions in Biobank Storage [0.03%]
生物样本库存储中监测温度异常的新型解决方案——指标管的应用
Patrick J Catterson,Tyler T Olson,Margaret B Penno et al.
Patrick J Catterson et al.
Maintaining the integrity of cryogenically preserved biological materials is critical, as even brief, undetected temperature excursions in storage can compromise sample viability. Existing monitoring systems may miss transient thaw-refreeze...
Accuracy of Patient Setup Using Surface Guided Radiotherapy (SGRT) for Abdominal Malignancies [0.03%]
表面引导放射治疗(SGRT)在腹部恶性肿瘤患者体位准确性中的应用
Varvara Sotiropoulou,Stefanos Kachris,Michalis Mazonakis
Varvara Sotiropoulou
This study aimed to evaluate the placement accuracy and reproducibility of Surface Guided Radiotherapy (SGRT) compared with the conventional tattoo/laser method in patients undergoing radiotherapy for abdominal malignancies. A retrospective...
Performing Dual Glucose Clamp Experiments in Sedated Farm Swine: A Practical Method [0.03%]
用于镇静家猪的双葡萄糖钳夹实验的方法探讨及实践
Marc C Torjman,Winston C Hamilton,Katherine Dillon et al.
Marc C Torjman et al.
The hyperinsulinemic-euglycemic clamp technique is considered the gold standard for measuring insulin sensitivity in large animals. We developed a practical method for conducting concurrent glucose clamp experiments in a pair of sedated far...
Antidepressant and Related Neurobiological and Neurophysiological Effects of Add-On Transcranial Direct Current Stimulation in Major Depressive Disorder with Residual Symptoms: A Randomized, Double-Blind Clinical Trial Protocol [0.03%]
经颅直流电刺激作为抑郁症残留症状的辅助治疗：一项随机双盲临床试验方案
Carmen Concerto,Fabrizio Bella,Cecilia Chiarenza et al.
Carmen Concerto et al.
Major depressive disorder (MDD) is a prevalent and disabling condition. Transcranial direct current stimulation (tDCS) may improve symptoms by modulating neuroplastic and inflammatory mechanisms. This randomized, double-blind, placebo-contr...
Effects of Different Centrifugation Parameters on Equilibrium Solubility Measurements [0.03%]
不同离心参数对平衡溶解度测定的影响
Rita Szolláth,Vivien Bárdos,Marcell Stifter-Mursits et al.
Rita Szolláth et al.
The bioavailability of a drug is closely linked to its solubility, making its early determination essential in drug development. The saturation shake-flask (SSF) method is the gold standard protocol for this, which includes a phase separati...
A Six-Step Protocol for Monitoring Antimicrobial Resistance Trends Using WHONET and R: Real-World Application and R Code Integration [0.03%]
使用WHONET和R监测抗菌药物耐药性趋势的六步流程：实际应用和R代码集成
Fabio Ingravalle,Antonio Vinci,Marco Ciotti et al.
Fabio Ingravalle et al.
Antimicrobial resistance is a global health issue, and the WHO has made significant efforts in the development of tools for its monitoring. However, such tools are underutilized, due to limited knowledge, technical capacity, and scarcity of...
Efficient Collection of Skin Biopsies Using the Tissue Sampling Unit® for Subsequent Cryopreservation and Culture of Fibroblasts [0.03%]
使用Tissue Sampling Unit高效采集皮肤活检标本并冷冻保存及培养成纤维细胞
Phillip H Purdy,Bethany Redel,Paula Chen et al.
Phillip H Purdy et al.
Dermal tissue samples are a rich source of germplasm because they can be readily collected, frozen as part of a genebank collection, digested and cultured, and used for a variety of purposes such as genotyping or other forms of genetic rese...
A Simple Method for Imaging and Quantifying Respiratory Cilia Motility in Mouse Models [0.03%]
小鼠模型中呼吸纤毛运动成像和定量的简单方法
Richard Francis
Richard Francis
A straightforward ex vivo approach has been developed and refined to enable high-resolution imaging and quantitative assessment of motile cilia function in mouse airway epithelial tissue, allowing critical insights into cilia motility and c...
Dose-Response Behavior of Dental Material Using General Kinetic Order and Lambert W Deconvolution Models in CW-OSL [0.03%]
连续波光学刺激(OSL)信号的动力学模型及材料的响应行为研究
Ioanna K Sfampa
Ioanna K Sfampa
The present study presents a comparative evaluation of two analytical deconvolution models applied to Optically Stimulated Luminescence (OSL) decay curves of zirconia-reinforced lithium silicate (ZLS), a glass-ceramic material with potentia...