Decoding yeast transcriptional regulation via a data-and mechanism-driven distributed large-scale network model [0.03%]
基于数据和机理的大规模分布式网络模型解析酵母转录调控
Xingcun Fan,Guangming Xiang,Wenbin Liao et al.
Xingcun Fan et al.
The complex transcriptional regulatory relationships among genes influence gene expression levels and play a crucial role in determining cellular phenotypes. In this study, we propose a novel, distributed, large-scale transcriptional regula...
Genomic and transcriptomic insights into the molecular responses of a biocrust-derived oleaginous microalga Vischeria sp. WL1 to nitrogen depletion and recovery [0.03%]
氮缺乏和恢复条件下生物地衣固碳微藻Vischeria sp. WL1分子响应的基因组和转录组学研究
Xiaolan Rao,Wensheng Liang,Xin Jing et al.
Xiaolan Rao et al.
Microalgae surviving in extreme conditions evolve tolerance mechanisms to diverse environmental stresses. Environmental nitrogen limitation or nitrogen starvation poses a significant threat to the growth of microalgae, but it is an effectiv...
High-efficiency patatin expression strategies in Komagataella phaffii (Pichia pastoris): Expression cassette toolbox and regulation of protein secretion [0.03%]
毕赤酵母高效表达马铃薯 Patatin 的策略：表达载体工具箱及调控蛋白分泌
Yue Huang,Shao Jia,Ying Lin et al.
Yue Huang et al.
Patatin, a prominent food protein derived from potatoes, is renowned for its exceptional nutritional value. Patatin has been characterized for its diverse physiological attributes, including esterase activity, antioxidative properties, chol...
Yushuo Liu,Guangyun Chu,Xiaoming Dong et al.
Yushuo Liu et al.
With the advancement of industry and bio-agriculture, the effective management of CO2 has emerged as a critical challenge for humanity. This study systematically explores multiple CO2 assimilation pathways using the comb-FBA algorithm, aimi...
Jiangming Zhu,Yaping Mao,Hongchun Mo et al.
Jiangming Zhu et al.
Squalene, a lipophilic triterpene with multifaceted bioactivities, faces bioproduction bottlenecks in microbial hosts due to inefficient biosynthetic pathways and limited storage capacity. Here, we address these challenges through systems m...
Recombinant production of amaranthin and other betalain variants with yeast cell factories [0.03%]
用于生产甜菜碱的重组酵母细胞工厂制造阿马兰辛和其他变异体
Christiane Glitz,Jane Dannow Dyekjær,Gian Maria Cristian Solimando et al.
Christiane Glitz et al.
Betalains are a class of natural pigments found in plants of the Caryophyllales order. Betanin is the dominant betalain on the food colour market, even though over 80 other variants are known. Recombinant production of betanin has recently ...
Enhancing 3-hydroxypropionic acid production from recombinant Saccharomyces cerevisiae for using rice straw hydrolysate and sugar cane industrial waste as substrate [0.03%]
增强重组酿酒酵母生产3-羟基丙酸水平以稻草水解液和甘蔗工业废糖蜜为底物
Supattra Lertsriwong,Phatcharaphong Khaosaart,Nassapat Boonvitthya et al.
Supattra Lertsriwong et al.
Rice straw and sugar cane industrial waste are a plentiful source of lignocellulosic biomass with a high polysaccharide content, that is hydrolyzed into sugar for microbial growth and their metabolites. 3-Hydroxypropionic acid (3-HP) is a p...
Transcriptomic studies on the product stress response revealed that YCF1 is a beneficial factor for progesterone production in Yarrowia lipolytica [0.03%]
转录组研究揭示YCF1是假丝酵母唇形酵母中用于生产孕酮的有利因素
Ying Wang,Ruosi Zhang,Mingdong Yao et al.
Ying Wang et al.
Progesterone is a widely used therapeutic hormone and a common precursor for the synthesis of pharmaceutical steroids in both mammals and plants. It has been successfully produced in heterologous microorganisms, but the market demand has no...
Improving fidaxomicin production through ARTP mutagenesis and fermentation optimization in Actinoplanes deccanensis [0.03%]
应用ARTP技术提高链霉德川菌发酵产菲达霉素B水平
Jing-Yi Ruan,Huang Xie,Yi-Lei Zheng et al.
Jing-Yi Ruan et al.
Fidaxomicin, a macrolide antibiotic, is widely used to treat Clostridioides difficile infection (CDI). It demonstrats significantly higher clinical efficacy than vancomycin and metronidazole. However, the large-scale industrial production o...
Construction of a genome-engineered stable 5-aminolevulinic acid producing Corynebacterium glutamicum by increasing succinyl-CoA supply [0.03%]
通过增加琥珀酰辅酶A的供应构建谷氨酸棒杆菌基因工程稳定的丙氨鳞酸生产菌株
Yangyang Zheng,Ziyao Wang,Jianbo Li et al.
Yangyang Zheng et al.
5-Aminolevulinic acid (5-ALA), a versatile precursor for tetrapyrrole derivatives (such as heme, chlorophyll, and cobalamin), drives advancing microbial cell factories to meet growing biomedical and industrial demands. However, there remain...