Structure-coevolution dual-guided engineering of C-glycosyltransferase enables high-level biosynthesis of vitexin in Yarrowia lipolytica [0.03%]
结构协同进化导向的C-糖基转移酶工程用于假丝酵母中维特辛的生物合成
Chu-Qi Shi,Yi-Jing Chen,Wen-Li Yang et al.
Chu-Qi Shi et al.
Flavonoid C-glycosides are bioactive compounds with significant pharmaceutical potential. While biosynthesis offers a sustainable and green alternative to traditional chemical synthesis, its industrial scalability has been hindered by the p...
Advances in detecting category A biothreat agents: Toward symptom-driven sensing strategies [0.03%]
A类生物威胁因子的检测方法研究进展：基于症状驱动的感应策略
Ruilin Li,Yongzhong Zhang,Qiuyu Fu et al.
Ruilin Li et al.
The rise of emerging technologies like synthetic biology and artificial intelligence has raised alarms about new forms of weaponized diseases, given their threat to life and societal economic burden. This underscores the critical role of de...
De novo biosynthesis of putrescine from glucose using engineered Escherichia coli in a two-step process [0.03%]
通过工程化的E. coli利用葡萄糖从头生物合成腐胺的两步法研究
Lang Yin,Hongxu Li,Min Du et al.
Lang Yin et al.
Putrescine, is a key monomer for the synthesis of high-performance polymer materials. However, its sustainable microbial production remains challenging in yield and efficiency. In this study, we developed a modular two-step biosynthesis pro...
Heterologous production of epothilones in Streptomyces albus J1074 via promoter engineering of the biosynthetic gene cluster and precursor supply enhancement [0.03%]
通过调控基因簇启动子和前体增强放线菌素异源高效合成 epothilones
Qingwen Cui,Shuo Wang,Xiaochen Li et al.
Qingwen Cui et al.
Epothilones, synthesized by hybrid polyketide synthases (PKS)-nonribosomal peptide synthetases (NRPS), are clinically valuable anti-cancer macrolides with potent activity against multidrug-resistant tumors. They are naturally produced by th...
Corrigendum to "Integrated amplification of NADPH-regenerating modules enhances cytidine biosynthesis in Escherichia coli" [Synth Syst Biotechnol 12 (2026) 320-329] [0.03%]
“整合放大NADPH再生模块可增强大肠杆菌中的胞苷生物合成”[Synth Syst Biotechnol 12 (2026) 320-329]的勘误表
Lu Liu,Xiangjun Zhang,Tengteng Zhu et al.
Lu Liu et al.
[This corrects the article DOI: 10.1016/j.synbio.2025.12.009.]. © 2026 The Authors.
Published Erratum
Synthetic and systems biotechnology. 2026 Mar 2:12:459. DOI:10.1016/j.synbio.2026.02.005 2026
AmXlnR, a transcription factor involved in xylan degradation and pentose catabolism, enhances pullulan production from xylose in Aureobasidium melanogenum [0.03%]
参与木聚糖降解和戊糖分解的转录因子AmXlnR可增强黑根霉Aureobasidium melanogenum从木糖生产低聚异麦芽糖的能力
Wen-Hui Zhao,Ya-Jun Liu,Lu-Lu Zhang et al.
Wen-Hui Zhao et al.
The abundant presence of xylan in low-cost lignocellulosic biomasses establishes its monomeric sugar, xylose, as a pivotal substrate for sustainable bioconversion processes. Although significant advances have been devoted to rewiring the me...
Metabolic modulation of TCA cycle by S-nitrosylation in Monascus spp [0.03%]
红曲霉菌株中TCA循环的S-亚硝基化修饰及其代谢调控研究
Zitong Meng,Yingao Tan,Yali Duan et al.
Zitong Meng et al.
Monascus spp. produces several beneficial secondary metabolites (SMs), such as Monacolin K and Monascus pigments, which have wide applications in the pharmaceutical and food industries. Various factors, including gene expression, regulate t...
Engineering Yarrowia lipolytica for nervonic acid production by organelle compartmentalization and dynamic promoter coordination [0.03%]
通过器官细胞区室化和动态启动子协调工程酵母生产神经酸
Sen Ye,Wenjing He,Niping Yang et al.
Sen Ye et al.
Nervonic acid (NA) is of great significance in repairing damaged nerve fibers and promoting the regeneration of neural cells. This study aimed to construct a Yarrowia lipolytica strain capable of producing NA. The β-oxidation pathway was f...
Modular reconstruction and multilevel regulation of Saccharomyces cerevisiae to drive the efficient synthesis of asiatic acid [0.03%]
模块化重建和多级调控酿酒酵母高效合成总冠酸的异源途径
Chen Sang,Wenqian Wei,Xinran Yin et al.
Chen Sang et al.
Asiatic acid, a pentacyclic triterpenoid compound, is highly valued in the fields of functional foods, pharmaceuticals, and cosmetics. However, its microbial synthesis has been constrained by an insufficient supply of key precursors. Additi...
Highly biased DNA sequence reconstruction in DNA storage with multi-scale attention mechanism and contrast learning [0.03%]
基于多尺度注意力机制和对比学习的DNA存储中偏置较大的DNA序列重建
Xue Li,Yanfen Zheng,Qi Shao et al.
Xue Li et al.
Base substitution, insertion, and deletion errors due to inherent technical constraints inducing unavoidable sequencing inaccuracies, limiting access to high-quality raw data and biological knowledge. To address this, we propose a deep sequ...