Investigating the consequences of asymmetric endoplasmic reticulum inheritance in Saccharomyces cerevisiae under stress using a combination of single cell measurements and mathematical modelling [0.03%]
结合单细胞测量和数学建模研究酵母在胁迫条件下内质网不对称分配的后果
Felix R H Jonas,Kate E Royle,Rochelle Aw et al.
Felix R H Jonas et al.
Adaptation allows organisms to maintain a constant internal environment, which is optimised for growth. The unfolded protein response (UPR) is an example of a feedback loop that maintains endoplasmic reticulum (ER) homeostasis, and is chara...
Engineering metabolic pathways in Amycolatopsis japonicum for the optimization of the precursor supply for heterologous brasilicardin congeners production [0.03%]
工程改造链霉霉素曲霉素菌代谢途径以优化前体供给从而增强巴西卡丁烷衍生物的异源合成
Paul N Schwarz,Luisa Roller,Andreas Kulik et al.
Paul N Schwarz et al.
The isoprenoid brasilicardin A is a promising immunosuppressant compound with a unique mode of action, high potency and reduced toxicity compared to today's standard drugs. However, production of brasilicardin has been hampered since the pr...
Comprehensive relative quantitative metabolomics analysis of lycopodium alkaloids in different tissues of Huperzia serrata [0.03%]
石松不同组织次生代谢产物石松碱的相对定量代谢组学分析
Shiwen Wu,Zhen Fan,Youli Xiao
Shiwen Wu
Qian ceng Ta, the whole plant of Huperzia serrata, is an important landscape and medicinal herbs and contains abundant bioactive lycopodium alkaloids. Although the structures of more than 100 lycopodium alkaloids in Huperzia serrata have be...
Alicia Berard,Andrea Kroeker,Peter McQueen et al.
Alicia Berard et al.
All cellular functions, ranging from regular cell maintenance and homeostasis, specialized functions specific to cellular types, or generating responses due to external stimulus, are mediated by proteins within the cell. Regulation of these...
Expanding beyond canonical metabolism: Interfacing alternative elements, synthetic biology, and metabolic engineering [0.03%]
超越经典代谢：非经典元素、合成生物学和代谢工程的接口技术
Kevin B Reed,Hal S Alper
Kevin B Reed
Metabolic engineering offers an exquisite capacity to produce new molecules in a renewable manner. However, most industrial applications have focused on only a small subset of elements from the periodic table, centered around carbon biochem...
Simple glycolipids of microbes: Chemistry, biological activity and metabolic engineering [0.03%]
微生物的简单糖脂：化学、生物学活性及代谢工程学
Ahmad Mohammad Abdel-Mawgoud,Gregory Stephanopoulos
Ahmad Mohammad Abdel-Mawgoud
Glycosylated lipids (GLs) are added-value lipid derivatives of great potential. Besides their interesting surface activities that qualify many of them to act as excellent ecological detergents, they have diverse biological activities with p...
Metabolic pathway engineering [0.03%]
代谢途径工程学
Hal S Alper,José L Avalos
Hal S Alper
Synergistic and non-specific nucleic acid production by T7 RNA polymerase and Bsu DNA polymerase catalyzed by single-stranded polynucleotides [0.03%]
单链多核苷酸催化T7 RNA聚合酶和Bsu DNA聚合酶协同非特异性合成核酸
Nicholas J Emery,Sagardip Majumder,Allen P Liu
Nicholas J Emery
Point-of-care molecular diagnostic tests show great promise for providing accurate, timely results in low-infrastructure healthcare settings and at home. The design space for these tests is limited by a variety of possible background reacti...
Improved production of docosahexaenoic acid in batch fermentation by newly-isolated strains of Schizochytrium sp. and Thraustochytriidae sp. through bioprocess optimization [0.03%]
通过生物过程优化提高裂殖壶菌和Thraustochytriidae藻株发酵生产二十二碳六烯酸水平
Qiuzhen Wang,Huike Ye,Biswarup Sen et al.
Qiuzhen Wang et al.
Thraustochytrids, rich in docosahexaenoic acid (DHA, C22:6ω3), represent a potential source of dietary fatty acids. Yet, the effect of culture conditions on growth and fatty acid composition vary widely among different thraustochytrid stra...
Prospective study of probiotic supplementation results in immune stimulation and improvement of upper respiratory infection rate [0.03%]
益生菌干预对上呼吸道感染发生率和免疫功能的影响：前瞻性研究
Hong Zhang,Chiajung Yeh,Zonglian Jin et al.
Hong Zhang et al.
The human gut microbiota is an important environmental factor for human health with evolutionarily conserved roles in immunity, metabolism, development, and behavior of the host. Probiotic organisms are claimed to offer several functional p...