Xiaoqiang Jia,Chang Liu,Hao Song et al.
Xiaoqiang Jia et al.
The rapid development of synthetic biology has conferred almost perfect modification on single cells, and provided methodological support for synthesizing microbial consortia, which have a much wider application potential than synthetic sin...
Generate a bioactive natural product library by mining bacterial cytochrome P450 patterns [0.03%]
通过挖掘细菌细胞色素P450模式来生成生物活性天然产物文库
Xiangyang Liu
Xiangyang Liu
The increased number of annotated bacterial genomes provides a vast resource for genome mining. Several bacterial natural products with epoxide groups have been identified as pre-mRNA spliceosome inhibitors and antitumor compounds through g...
In silico methods for linking genes and secondary metabolites: The way forward [0.03%]
次级代谢组学中的基因-化学关系及网络研究展望
Shradha Khater,Swadha Anand,Debasisa Mohanty
Shradha Khater
In silico methods for linking genomic space to chemical space have played a crucial role in genomics driven discovery of new natural products as well as biosynthesis of altered natural products by engineering of biosynthetic pathways. Here ...
The secondary metabolite bioinformatics portal: Computational tools to facilitate synthetic biology of secondary metabolite production [0.03%]
次级代谢物生物信息学门户网站：促进次级代谢物生产合成生物学的计算工具
Tilmann Weber,Hyun Uk Kim
Tilmann Weber
Natural products are among the most important sources of lead molecules for drug discovery. With the development of affordable whole-genome sequencing technologies and other 'omics tools, the field of natural products research is currently ...
Genome mining reveals the biosynthetic potential of the marine-derived strain Streptomyces marokkonensis M10 [0.03%]
基因组测序挖掘揭示了来自摩洛哥的海洋链霉菌M10菌株的次级代谢潜力
Liangyu Chen,Ying-Mi Lai,Yu-Liang Yang et al.
Liangyu Chen et al.
Marine streptomycetes are rich sources of natural products with novel structures and interesting biological activities, and genome mining of marine streptomycetes facilitates rapid discovery of their useful products. In this study, a marine...
Systematic development of biomass overproducing Scheffersomyces stipitis for high-cell-density fermentations [0.03%]
系统开发生物量过量产生的Scheffersomyces stipitis用于高细胞密度发酵
Pornkamol Unrean,Sukanya Jeennor,Kobkul Laoteng
Pornkamol Unrean
The development of economically feasible bio-based process requires efficient cell factories capable of producing the desired product at high titer under high-cell-density fermentation. Herein we present a combinatorial approach based on sy...
Inactivation of SACE_3446, a TetR family transcriptional regulator, stimulates erythromycin production in Saccharopolyspora erythraea [0.03%]
SACE_3446（TetR家族转录调控因子）失活可刺激红色链丝菌产生红霉素
Hang Wu,Yansheng Wang,Li Yuan et al.
Hang Wu et al.
Erythromycin A is a widely used antibiotic produced by Saccharopolyspora erythraea; however, its biosynthetic cluster lacks a regulatory gene, limiting the yield enhancement via regulation engineering of S. erythraea. Herein, six TetR famil...
Improved production of cytotoxic thailanstatins A and D through metabolic engineering of Burkholderia thailandensis MSMB43 and pilot scale fermentation [0.03%]
通过Burkholderia thailandensis MSMB43代谢工程改进细胞毒thailanstatins A和D的生产并进行中试发酵
Xiangyang Liu,Hui Zhu,Sreya Biswas et al.
Xiangyang Liu et al.
Thailanstatin A (TST-A) is a potent antiproliferative natural product discovered by our group from Burkholderia thailandensis MSMB43 through a genome-guided approach. The limited supply of TST-A, due to its low titer in bacterial fermentati...
In vitro reconstitution guide for targeted synthetic metabolism of chemicals, nutraceuticals and drug precursors [0.03%]
化学、营养药品和药物前体靶向合成代谢的体外重组指南
Gao-Yi Tan,Faying Zhu,Zixin Deng et al.
Gao-Yi Tan et al.
With the developments in metabolic engineering and the emergence of synthetic biology, many breakthroughs in medicinal, biological and chemical products as well as biofuels have been achieved in recent decades. As an important barrier to tr...