De novo biosynthesis of 1,5-diamino-2-hydroxypentane from glucose via combination of fermentation and whole-cell catalysis [0.03%]
葡萄糖发酵和全细胞催化偶联生产1,5-戊二胺
Zhijie Zheng,Zhongliang Chen,Tongqing Tang et al.
Zhijie Zheng et al.
1,5-Diamino-2-hydroxypentane (2-OH-PDA) is a novel aliphatic β-amino alcohol with potential for a wide range of applications, and its efficient and green synthesis has attracted increasing attention. In this study, we developed a biosynthe...
Combining multiplex metabolic engineering with adaptive evolution strategies for high-level succinic acid production in Yarrowia lipolytica [0.03%]
结合多重复合代谢工程和适应性进化策略在安丝丝酵母中高效生产丁二酸
Tao Sun,Mei-Li Sun,Lu Lin et al.
Tao Sun et al.
Succinic acid, an essential platform chemical with extensive utility in biodegradable materials, pharmaceuticals, and the food industry, faces challenges of high energy consumption and environmental pollution in traditional chemical synthes...
Construction and analysis of a cell factory for terpenoid biosynthesis in Pichia pastoris via metabolic engineering and metabolomics [0.03%]
基于代谢工程和代谢组学的毕赤酵母倍半萜细胞工厂的构建及分析研究
Chenfan Sun,Cuifang Ye,Xiaoqian Li et al.
Chenfan Sun et al.
Terpenoids are widely distributed in nature and have various applications in health products, pharmaceuticals, and fragrances. Despite the tremendous potential of terpenoids, traditional production methods such as plant extraction and chemi...
Enhanced vitamin B6 production in engineered Escherichia coli via restricted mix-carbon feeding and pressure-controlled fermentation [0.03%]
通过限制混合碳源供给和压力控制发酵增强工程大肠杆菌维生素B6的生产
Long Chen,Miao-Miao Xia,Hui-Na Dong et al.
Long Chen et al.
Pyridoxine (PN), a major commercial form of vitamin B6, is mainly produced via chemical synthesis, raising environmental concerns. Microbial fermentation offers a greener alternative, but low biomass and titer limit industrial application. ...
A near-infrared ratio fluorescent probe achieves mitochondrial hydrogen polysulfide imaging for monitoring ferroptosis in arthritis [0.03%]
近红外比率荧光探针实现关节炎铁死亡监测的线粒体多硫氢成像
Ting Cao,Ziwen Xiao,Wenhua Dong et al.
Ting Cao et al.
Reactive sulfur (RSS) is a type of sulfur-containing molecule widely present in biological systems. Hydrogen polysulfide (H2Sn, n > 1), as a member of the active sulfur family, plays an indispensable role in many physiological and pathologi...
Biosynthesis of ent-acu-dioxomorpholine A and its conversion to prenyl-rearranged and rare ketooxadiazepane products in heterologous host [0.03%]
异源宿主中_ent-Acu-Dioxomorpholine A_的生物合成及其转化为重排和罕见的酮氧杂环十二烷产物
Qiaoqiao Tao,Yi Zou
Qiaoqiao Tao
Diketomorpholines (DKMs) represent an intriguing class of biologically active heterocycles. To identify unusual DKM natural products, we conducted a comprehensive analysis of fungal genomes from NCBI and our laboratory databases. A non-ribo...
Multi-omics analyses of evolved Corynebacterium glutamicum mutants reveal the molecular responses to formaldehyde stress [0.03%]
多组学分析进化得到的安琪酵母突变体揭示甲醛胁迫的分子响应机制
Liwen Fan,Qichen Cao,Zhihui Zhang et al.
Liwen Fan et al.
Formaldehyde serves as a crucial intermediate metabolite during C1 compounds biotransformation. To optimize C1 utilization efficiency, it is essential to identify genes related to formaldehyde tolerance and enhance microbial resistance. Hen...
Enhanced spinosad production in Saccharopolyspora spinosa by employing mannose as an extracellular carbon reservoir and optimizing acetyl-CoA supply pathway [0.03%]
采用甘露糖作为细胞外碳库及优化乙酰辅酶A供应途径提高刺糖多孢菌产沟槽链霉素水平
Zirong Zhu,Qin Zhao,Yan Zhu et al.
Zirong Zhu et al.
Spinosad, a potent broad-spectrum insecticidal polyketide produced by Saccharopolyspora spinosa, faces limitations in industrial-scale production due to inherent inefficiencies in its native biosynthetic pathways. To overcome this constrain...
Corrigendum to "The coupling effect of Penicillium baileys W2 in the Aspergillus flavus inhibition and peanut growth promotion" [Synth Syst Biotechnol 11 (2026) 127-140] [0.03%]
“Penicillium baileys W2在抑制Aspergillus flavus和促进花生生长偶合效应中的作用”一文的勘误通知
Qianqian Wang,Shihua Shan,Quanxi Sun et al.
Qianqian Wang et al.
[This corrects the article DOI: 10.1016/j.synbio.2025.09.003.]. © 2026 The Authors.
Metabolic and transport engineering enable efficient de novo biosynthesis of patchoulol in Saccharomyces cerevisiae [0.03%]
代谢工程与运输工程使佛手柑醇在酿酒酵母中从头生物合成效率得到提高
Danni Fu,Yongyi Zhou,Ziying Wu et al.
Danni Fu et al.
Patchoulol is a valuable sesquiterpene for fragrance and cosmetics, but plant extraction is slow and resource-intensive. Here, we combined enzyme, pathway and transporter engineering to build a yeast chassis for high-titer patchoulol produc...