SCO3129, a TetR family regulator, is responsible for osmotic stress in Streptomyces coelicolor [0.03%]
调控链霉菌渗透压胁迫的TetR家族调控蛋白SCO3129
Xihong He,Hong Li,Yuanyuan Pan et al.
Xihong He et al.
Streptomyces are the soil-dwelling bacteria with a complex lifecycle and a considerable ability to produce a variety of secondary metabolites. Osmoregulation is important for their lifecycle in nature. In the genome of Streptomyces coelicol...
Activation of three natural product biosynthetic gene clusters from Streptomyces lavendulae CGMCC 4.1386 by a reporter-guided strategy [0.03%]
通过报告因子引导策略激活红链霉菌CGMCC 4.1386三条天然产物生物合成基因簇
Pengwei Li,Zhengyan Guo,Wei Tang et al.
Pengwei Li et al.
Along with the fast developing of DNA sequencing technology, a great number of natural product biosynthetic gene clusters have been discovered by bioinformatic analysis, which demands novel high-throughput genome mining methods to obtain th...
Nocardiopsistins A-C: New angucyclines with anti-MRSA activity isolated from a marine sponge-derived Nocardiopsis sp. HB-J378 [0.03%]
诺卡菌素A-C：三种具有抗MRSA活性的新型安古 cycline 类化合物及其绝对构型确定
Dongbo Xu,Keshav K Nepal,Jing Chen et al.
Dongbo Xu et al.
Marine natural products have become an increasingly important source of new drug leads during recent years. In an attempt to identify novel anti-microbial natural products by bioprospecting deep-sea Actinobacteria, three new angucyclines, n...
Fei Huang
Fei Huang
Lysine acetyltransferases (KATs) catalyze lysine acetylation, a reversible protein modification implicated in a wide variety of disease states. Histone acetyltransferases (HATs) comprise a KAT sub-class that acetylate specific lysines in hi...
Enhancement of precursor amino acid supplies for improving bacitracin production by activation of branched chain amino acid transporter BrnQ and deletion of its regulator gene lrp in Bacillus licheniformis [0.03%]
通过活化支链氨基酸转运蛋白BrnQ及其调节基因lrp敲除增强前体氨基酸供应以提高地霉素发酵水平
Jiang Zhu,Dongbo Cai,Haixia Xu et al.
Jiang Zhu et al.
Bacitracin, a new type of cyclic peptide antibiotic, is widely used as the feed additive in feed industry. Branched chain amino acids (BCAAs) are the key precursors for bacitracin synthesis. In this research, soybean meal was served as the ...
Regulation of antibiotic biosynthesis in actinomycetes: Perspectives and challenges [0.03%]
放线菌抗生素生物合成调控机制研究：现状与挑战
Junhong Wei,Lang He,Guoqing Niu
Junhong Wei
Actinomycetes are the main sources of antibiotics. The onset and level of production of each antibiotic is subject to complex control by multi-level regulators. These regulators exert their functions at hierarchical levels. At the lower lev...
Blossom of CRISPR technologies and applications in disease treatment [0.03%]
CRISPR技术与应用的兴起及其在疾病治疗中的作用
Huayi Liu,Lian Wang,Yunzi Luo
Huayi Liu
Since 2013, the CRISPR-based bacterial antiviral defense systems have revolutionized the genome editing field. In addition to genome editing, CRISPR has been developed as a variety of tools for gene expression regulations, live cell chromat...
Cell lysates and egg white create homeostatic microenvironment for gene expression in cell-free system [0.03%]
细胞裂解产物和蛋清在无细胞系统中构建基因表达的生理环境
Yang Liu,Dayong Yang
Yang Liu
Homeostasis widely exists in living systems, and plays essential roles for maintaining normal physiological activities, enabling to preserve their functionalities against variations. Gene expression is a crucial process that allows cells to...
Conversion of d-glucose to l-lactate via pyruvate by an optimized cell-free enzymatic biosystem containing minimized reactions [0.03%]
通过最小化反应的细胞 free 生物系统将d-葡萄糖转化为乳酸的最佳方案
Leipeng Xie,Xinlei Wei,Xigui Zhou et al.
Leipeng Xie et al.
Cell-free synthetic enzymatic biosystem is emerging to expand the traditional biotechnological mode by utilizing a number of purified/partially purified enzymes and coenzymes in a single reaction vessel for the production of desired product...