Advances in the biosynthesis of tetraacetyl phytosphingosine, a key substrate of ceramides [0.03%]
鞘氨醇脂质体四乙酰化衍生物生物合成的研究进展
Xin Zhang,Xiaochen Zhang,Lu Lin et al.
Xin Zhang et al.
Ceramides, formed by the dehydration of long-chain fatty acids with phytosphingosine and its derivatives, are widely used in skincare, cosmetics, and pharmaceuticals. Due to the exceedingly low concentration of phytosphingosine in plant see...
Comparative omics directed gene discovery and rewiring for normal temperature-adaptive red pigment synthesis by polar psychrotrophic fungus Geomyces sp. WNF-15A [0.03%]
比较转录组和代谢组学指导的基因挖掘及改造低温适应性红色素合成菌极地低温真菌Geomyces sp. WNF-15A
Haoyu Long,Jiawei Zhou,Yanna Ren et al.
Haoyu Long et al.
The Antarctic fungus Geomyces sp. WNF-15A can produce high-quality red pigments (AGRP) with good prospects for the use in food and cosmetic area. However, efficient AGRP synthesis relies on low-temperature and thus limits its industrial dev...
Liposome-based RNAi delivery in honeybee for inhibiting parasite Nosema ceranae [0.03%]
基于脂质体的RNAi递送技术在蜜蜂中抑制微孢子虫 Nosema ceranae入侵的作用研究
Yue Qi,Chen Wang,Haoyu Lang et al.
Yue Qi et al.
Nosema ceranae, a parasite that parasitizes and reproduces in the gut of honeybees, has become a serious threat to the global apiculture industry. RNA interference (RNAi) technology can be used to inhibit N. ceranae growth by targeting sile...
Synergistic increase in coproporphyrin III biosynthesis by mitochondrial compartmentalization in engineered Saccharomyces cerevisiae [0.03%]
工程酵母酿酒酵母中线粒体区隔化协同增加粪卟啉Ⅲ生物合成
Qidi Guo,Jiaqi Xu,Jiacun Li et al.
Qidi Guo et al.
Coproporphyrin III (CP III), a natural porphyrin derivative, has extensive applications in the biomedical and material industries. S. cerevisiae has previously been engineered to highly accumulate the CP III precursor 5-aminolevulinic acid ...
Heterologous activation and metabolites identification of the pks7 gene cluster from Saccharopolyspora erythraea [0.03%]
链霉红单胞菌pks7基因簇的异源激活及代谢产物分析
Hao Tang,Xingchi Yang,Wenzong Wang et al.
Hao Tang et al.
The microbial genome remains a huge treasure trove for the discovery of diverse natural products. Saccharopolyspora erythraea NRRL23338, the industry producer of erythromycin, has a dozen of biosynthetic gene clusters whose encoding product...
Enhanced triacylglycerol metabolism contributes to the efficient biosynthesis of spinosad in Saccharopolyspora spinosa [0.03%]
改良三酰甘油代谢可促进刺糖多孢菌中新型抗生素 spinsorolid 的高效生物合成
Li Cao,Yangchun Liu,Lin Sun et al.
Li Cao et al.
Triacylglycerol (TAG) is crucial for antibiotic biosynthesis derived from Streptomyces, as it serves as an important carbon source. In this study, the supplementation of exogenous TAG led to a 3.92-fold augmentation in spinosad production. ...
Cyanamide-inducible expression of homing nuclease I- Sce I for selectable marker removal and promoter characterisation in Saccharomyces cerevisiae [0.03%]
用次氨基氰诱导I-SceI位点特异性核酸酶在酿酒酵母中进行筛选标记消除及启动子研究
Liam McDonnell,Samuel Evans,Zeyu Lu et al.
Liam McDonnell et al.
In synthetic biology, microbial chassis including yeast Saccharomyces cerevisiae are iteratively engineered with increasing complexity and scale. Wet-lab genetic engineering tools are developed and optimised to facilitate strain constructio...
Zheyi Kuang,Xiaofang Yan,Yanfei Yuan et al.
Zheyi Kuang et al.
Microorganisms, particularly extremophiles, have evolved multiple adaptation mechanisms to address diverse stress conditions during survival in unique environments. Their responses to environmental coercion decide not only survival in sever...
Stepwise increase of fidaxomicin in an engineered heterologous host Streptomyces albus through multi-level metabolic engineering [0.03%]
通过多级代谢工程逐步提高streptomyces albus异源宿主中fidaxomicin的产量
Huang Xie,Yi-Ting Su,Qing-Ting Bu et al.
Huang Xie et al.
The anti-Clostridium difficile infection (CDI) drug fidaxomicin is a natural polyketide metabolite mainly produced by Micromonosporaceae, such as Actinoplanes deccanensis, Dactylosporangium aurantiacum, and Micromonospora echinospora. In th...
A systematic discussion and comparison of the construction methods of synthetic microbial community [0.03%]
合成微生物群落的构建方法及系统比较与讨论
Chenglong Li,Yanfeng Han,Xiao Zou et al.
Chenglong Li et al.
Synthetic microbial community has widely concerned in the fields of agriculture, food and environment over the past few years. However, there is little consensus on the method to synthetic microbial community from construction to functional...