Mechanistic insights into the orthogonal functionality of an AHL-mediated quorum-sensing circuit in Yersinia pseudotuberculosis [0.03%]
耶尔森菌伪结核耶尔森菌AHL依赖型群体感应回路正交功能的机制研究
Boyu Luo,Shanshan Wu,Wei Liu et al.
Boyu Luo et al.
YpsR, a pivotal regulatory protein in the quorum-sensing (QS) of Yersinia pseudotuberculosis(Y. pstb), is essential for molecular signaling, yet its molecular mechanisms remain poorly understood. Herein, this study systematically investigat...
Efficient biosynthesis of β-caryophyllene in Saccharomyces cerevisiae by β-caryophyllene synthase from Artemisia argyi [0.03%]
来源于艾叶的愈创奥刺茋烯合成酶高效催化酿酒酵母合成愈创奥刺茋烯
Zhengping Li,Yuhong Gan,Changyu Gou et al.
Zhengping Li et al.
Artemisia argyi H. Lév. & Vaniot is an important traditional Chinese medicinal plant known for its volatile oils, which are the main active components of A. argyi, including monoterpenes, sesquiterpenes and their derivatives. Despite its m...
Transcriptome analysis reveals methanol metabolism variations for the growth damage caused by overexpression of chimeric transactivators in Pichia pastoris [0.03%]
转录组分析揭示了酿酒酵母毕赤氏亚种中嵌合型激活子过表达所造成生长损伤的甲醇代谢差异
Qi Liu,Ziyu He,Menghao Cai
Qi Liu
Methanol is a promising substrate for sustainable biomanufacturing, and Pichia pastoris has become a commonly used yeast for methanol utilization due to its powerful methanol metabolic pathways and methanol inducible promoter. Previous reco...
CRISPR/Cas12a-based genome editing for cyanophage of Anabeana sp [0.03%]
基于CRISPR / Cas12a的念珠蓝藻病毒基因组编辑
Shengjian Yuan,Yanchen Li,Chunhua Kou et al.
Shengjian Yuan et al.
Efforts have been conducted on cyanobacterial genome editing, yet achieving genome editing in cyanophages remains challenging. Editing cyanophage genomes is crucial for understanding and manipulating their interactions with cyanobacterial h...
Development of a green Komagataella phaffii cell factory for sustainable production of plant-derived sesquiterpene (-)-α-bisabolol [0.03%]
解脂耶罗孢菌细胞工厂的开发可持续生产来源于植物的倍半萜(-)-α- bisabolol
Jintao Cheng,Zhongji Pu,Jiali Chen et al.
Jintao Cheng et al.
(-)-α-Bisabolol is a plant-derived sesquiterpene derived from Eremanthus erythropappus, which can be used as a raw material in cosmetics and has anti-inflammatory function. In this study, we designed six mutation sites of the (-)-α-bisabo...
Developing polycistronic expression tool in Yarrowia lipolytica [0.03%]
开发Yarrowia lipolytica多顺反子表达工具
Donghan Li,Jianhui Liu,Lingxuan Sun et al.
Donghan Li et al.
Unconventional oleaginous yeast Yarrowia lipolytica has gained widespread applications as a microbial cell factory for synthesizing various chemicals and natural products. The construction of efficient cell factories requires intricate meta...
Yongjin Zhou,Benjamin Woolston
Yongjin Zhou
Assessing the physiological properties of baker's yeast based on single-cell Raman spectrum technology [0.03%]
基于单细胞拉曼光谱技术评估酵母的生理属性
Xi Sun,Xin Zhou,Ran Yu et al.
Xi Sun et al.
With rapid progress in the yeast fermentation industry, a comprehensive commercial yeast quality assessment approach integrating efficiency, accuracy, sensitivity, and cost-effectiveness is required. In this study, a new yeast quality asses...
Revolutionizing biotechnology advances natural products discovery and industrial processing [0.03%]
生物科技革新推动天然产物发现和工业加工转型升级
Yaojun Tong,Tilmann Weber
Yaojun Tong
Predicting effective drug combinations for cancer treatment using a graph-based approach [0.03%]
基于图的癌症治疗有效药物组合预测方法
Qi Wang,Xiya Liu,Guiying Yan
Qi Wang
Drug combination therapy, involving the use of two or more drugs, has been widely employed to treat complex diseases such as cancer. It enhances therapeutic efficacy, reduces drug resistance, and minimizes side effects. However, traditional...