Thermodynamic metabolic modeling of growth and bioproduction potential of the acetogen Acetobacterium woodii with and without redox cofactor swaps [0.03%]
红氧辅因子交换条件下关于acetogen阿克托杆菌Woodii生长及生物产量的热力学代谢模型模拟研究
Jasmin Bauer,Axel von Kamp,Stefan Pflügl et al.
Jasmin Bauer et al.
Acetogenic bacteria such as Acetobacterium woodii use the Wood-Ljungdahl pathway to convert H2/CO2 and other C1 substrates into acetate and couple it via chemiosmotic energy conservation with ATP synthesis. To coordinate the associated elec...
Metabolic engineering of Vibrio natriegens for the efficient biosynthesis of ergothioneine from sucrose using non-sterile fed-batch fermentation [0.03%]
基于弗氏弧菌的非无菌分批补料发酵制备鹅膏硫氨酸
Xinhui Liang,Yue Wang,Yifei Lv et al.
Xinhui Liang et al.
Fast-growing Vibrio natriegens is now recognized as a next-generation chassis for synthetic biology and biotechnology; however, its low transformation efficiency, limited gene editing methods and high fermentation cost are still the main ch...
Streptomyces: boost chassis strains for production of invaluable natural products [0.03%]
链霉菌：开发生产宝贵天然产物的细胞工厂
Simin Chen,Siqi Ling,Jinpin Li et al.
Simin Chen et al.
Streptomyces species continue to occupy a pivotal role in natural product biosynthesis, owing to their unparalleled metabolic diversity and genetic adaptability. This review focuses on cutting-edge advances documented from 2020 to 2025 (enc...
De novo production of (-)-limonene, (-)-carveol and (-)-carvone via engineering Rhodotorula toruloides [0.03%]
通过改造红球菌生产(-)-柠檬烯、(-)-丁香烯醇和(-)-丁香烯酮
Yaqi Dong,Simin Cui,Biao Du et al.
Yaqi Dong et al.
De novo biosynthesis of (-)-limonene, (-)-carveol and (-)-carvone was achieved via rewiring the mevalonate pathway in the oleaginous yeast Rhodotorula toruloides. Strategies including enzyme selection, protein fusion, pathway optimization (...
Metabolic engineering of Saccharomyces cerevisiae for co-production of ergothioneine, salidroside and gadusol [0.03%]
利用代谢工程将药用真菌红没药素、沙利多SIDE和gadusol共同生产的酿酒酵母细胞系工程化
Leyi Zhang,Sen Xiao,Daoan Wang et al.
Leyi Zhang et al.
Ergothioneine (EGT), salidroside and gadusol are high-value cosmetic ingredients valued for their moisturizing, skin-brightening and ultraviolet (UV)-protective properties. Leveraging Saccharomyces cerevisia, a GRAS organism already widely ...
Engineering an asymmetric cross-feeding consortium in Ogataea polymorpha driven by sulfur metabolism [0.03%]
基于硫代谢驱动的Ogataea polymorpha不对称互养 Consortium 生态工程
Yuxia Fan,Xiaoxin Zhai,Yongjin J Zhou et al.
Yuxia Fan et al.
Microbial cell factories offer a sustainable route for chemical production, yet reconstructing complex pathways in a single host often leads to metabolic burden and imbalanced flux. Here we establish an auxotrophy-based cross-feeding strate...
Wenbo Lin,Yu Lv,Yuhao Zhang et al.
Wenbo Lin et al.
Transposons are mobile genetic elements that have attracted sustained scientific interest since their discovery in maize, evolving into indispensable tools in genetic research. Saccharomyces cerevisiae serves as a preferred model for transp...
Synergistic interactions in designed bacterial consortia: Dual effects on control rusty root rot and growth promotion in ginseng [0.03%]
设计的细菌联合体在控制人参锈根病和促生上的协同作用研究
Meng Tian,Yu Wang,Keying Sun et al.
Meng Tian et al.
Ginseng rusty root rot, caused by Ilyonectria robusta, is the most severe soil-borne disease affecting ginseng cultivation. A synthetic microbial community (SynCom) was developed for the first time using antagonistic and growth-promoting en...
A cell-free system for 1,6-hexanediamine synthesis using bulk chemical caprolactam as the feedstock [0.03%]
以环己酮肟为原料的生物合成法高效获得己二胺的细胞体系研究
Ren Liu,Chouqiang Li,Yihui Zhang et al.
Ren Liu et al.
Biomanufacturing, with its advantages of mildness, low carbon emissions, and renewability, drives the frontier of green chemistry and sustainable development. However, complex metabolic pathways and intracellular resource competition freque...
Structure characterization assists rational design of polyethyleneglycol diglycidyl ether (PEGDE) substituted hyaluronic acid [0.03%]
结构表征辅助理性的聚乙二醇双缩水甘油醚（PEGDE）取代透明质酸的设计
Yiyang Wu,Yujuan Chen,Siran Zhao et al.
Yiyang Wu et al.
Polyethyleneglycol diglycidyl ether (PEGDE) is a new generation of cross-linker with the advantages of low toxicity and improved elasticity. The physicochemical properties of PEGDE-HA are closely related to its degree of modification (MoD),...