Jiling Feng,Yu Zeng,Shengli Li
Jiling Feng
A recent study in Science by Ely et al. identifies immunogenic, cancer-restricted noncanonical HLA-I-bound peptides (ncHLAp) in pancreatic cancer. Using a translation-informed filtering strategy, the study uncovers cryptic antigens derived ...
Leveraging immunologically based therapies to treat diffuse large B-cell lymphoma [0.03%]
利用免疫疗法治疗弥漫性大B细胞淋巴瘤
Jennifer K Lue,Sean E Healton,Gilles A Salles
Jennifer K Lue
Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of aggressive lymphomas driven by distinct biological pathways. Although historically divided into two major subtypes on the basis of putative cell of origin, detailed genomic a...
Vincent Mittelheisser,Cristina Liboni,Silvia Maria Grazia Trivigno et al.
Vincent Mittelheisser et al.
The dreadful liaison between platelets and tumor cells was discovered half a century ago. Since then, a plethora of studies have characterized the contribution of platelets to primary tumor development, survival of circulating tumor cells i...
Debolina Ganguly,Judith Agudo
Debolina Ganguly
The site of metastatic disease influences treatment response. A recent study in Cancer Cell by Cheng et al. revealed that bone metastases systemically impair immune function, abrogating immunotherapy response. Bone metastases led to osteopo...
Kostas A Papavassiliou,Alice G Vassiliou,Athanasios G Papavassiliou
Kostas A Papavassiliou
Little is known about lung precancer progression. Recently, Zhu et al. explored the early immunologic landscape of lung adenocarcinoma (LUAD) precursors and identified T cell immunoglobulin and mucin domain 3 (TIM-3) as a putative immune ch...
Constant Adriaan Tellinga,Roman Friedli,Federico Simonetta et al.
Constant Adriaan Tellinga et al.
Adoptive cell therapies (ACTs), such as chimeric antigen receptor (CAR)-T cell therapy, have revolutionized cancer treatment, especially for hematological cancers. However, patient responses vary considerably. Emerging research reveals a st...
Max Hüllwegen,Maximilian Kleinert,Stephan von Haehling et al.
Max Hüllwegen et al.
Most patients with advanced cancer suffer from cachexia, a complex metabolic disorder characterized by unintentional body weight loss that diminishes their quality of life and reduces the effectiveness of therapies. Currently, effective tre...
Magnus Haughey,Imran Noorani,Charles Swanton et al.
Magnus Haughey et al.
Cancers are complex, diverse, and elusive, with extrachromosomal DNA (ecDNA) recently emerging as a crucial player in driving the evolution of about 20% of all tumors. In this review we discuss open questions concerning the evolutionary rol...
Bo He,Ruth Ganss
Bo He
Pericytes play an important physiological role as guardians of vascular integrity. In cancer, however, pericytes undergo profound phenotypic changes which foster tumor progression. Emerging transcriptomics and functional data provide eviden...
Yan-Ruide Li,Yichen Zhu,Lili Yang
Yan-Ruide Li
IL-18-armored chimeric antigen receptor (CAR)-engineered T (18.CAR-T) cells have demonstrated enhanced antitumor efficacy in lymphoma patients refractory to conventional CAR-T therapy. Unraveling the mechanisms behind this potent enhancemen...