Cecilie Ø Madsen,Thomas M Hulen,Maria Ormhøj et al.
Cecilie Ø Madsen et al.
Chimeric antigen receptor (CAR)-T cell therapy has reshaped cancer immunotherapy for hematological malignancies, yet progress in solid tumors remains limited. Physical barriers, antigen heterogeneity, and immunosuppressive tumor microenviro...
Ningning Niu,Mo Chen,Jing Xue
Ningning Niu
Epigenetic dysregulation including frequent mutations in epigenetic regulators alongside nonmutational reprogramming driven by oncogenic and metabolic stresses represents a hallmark of pancreatic ductal adenocarcinoma (PDAC). Recent advance...
Mustafa Sibai,Martin Zacharias,Nicholas McGranahan et al.
Mustafa Sibai et al.
The Hallmarks of Cancer framework provided a unifying description of tumor capabilities, but in its static form, it cannot capture where in a tumor these traits occur, when they arise, or how they reorganize under selection pressure. Here, ...
Laura Merlet,Margaux Le Guyon,Julie Gavard
Laura Merlet
Once viewed solely as degradative compartments, lysosomes shape cell fate through signaling, metabolism, and communication. In glioblastoma, their rewiring underlies plasticity, invasion, and resistance to therapies. This forum explores lys...
Pooja Kumari,Zacary P Germon,Evangeline R Jackson et al.
Pooja Kumari et al.
Reactive oxygen species (ROS) are essential second-messenger molecules, yet when deregulated, they fuel cancer growth and therapeutic resistance. In high-grade gliomas, including glioblastoma, diffuse hemispheric glioma, and diffuse midline...
Zora Baumann,Eric Billy,Manuel C Scheidmann
Zora Baumann
Metastases cause most cancer-related deaths, underscoring the need for therapies targeting metastatic stages, including the tumor microenvironment. Yet translating biological insights into treatments remains difficult. Preclinical metastasi...
Supriya Sharma,Ajay Dixit
Supriya Sharma
Interleukin 33 (IL33) in the tumor microenvironment of pancreatic cancer has been linked to both pro- and antitumor immune responses, suggesting a context-dependent role. Herein, we discuss the current understanding and challenges of therap...
Sarah Cronjaeger,Lena Seifert,Adrian M Seifert
Sarah Cronjaeger
Nectin-4 is an immunoglobulinlike cell adhesion molecule that contributes to tumor aggressiveness and immune evasion in pancreatic ductal adenocarcinoma (PDAC). Its high and selective expression on pancreatic cancer cells, together with the...
Ali Valipour Motlagh,Eyad Elkord,Weiwei Dai
Ali Valipour Motlagh
Ammonia acts as a metabolic checkpoint fueling regulatory T cells (Tregs). Gu et al. demonstrate that utilizing argininosuccinate lyase-linked survival buffering and a FOXP3-spermine-PPARγ axis for mitochondrial reinforcement allows Tregs ...
Terrance J Haanen rd,David D Schlaepfer
Terrance J Haanen rd
The FDA recently granted accelerated approval of the small-molecule focal adhesion kinase (FAK) inhibitor (FAKi, defactinib) in combination with a RAF-MEK clamp inhibitor (avutometinib) for KRAS-mutated low-grade serous ovarian cancer devel...