Xi Wang,Yilong Zou
Xi Wang
While the initial transformation of cancer cells is driven by genetic alterations, tumor cell behaviors and functional states are dynamically regulated by cell-intrinsic factors including proteins, metabolites and lipids, and extrinsic micr...
Functional plasticity of RNA-binding proteins in cancer: both friend and foe [0.03%]
RNA结合蛋白在癌症中的功能可塑性：敌亦是友
Lauren Harrison-Oakes,Wisdom Igiogbe,Diu T T Nguyen
Lauren Harrison-Oakes
RNA-binding proteins (RBPs) govern RNA-based post-transcriptional processes that generate the abundance and diversity of the proteome. RBPs have recently emerged as crucial cancer regulators that can influence multiple cancer hallmarks. How...
Ada Junquera,Anniina Färkkilä
Ada Junquera
Multi-omics integration is reshaping cancer research by combining histopathology, transcriptomics, and proteomics with spatial and temporal context. Schweizer et al. revealed compartment-specific biology, RNA-protein decoupling, and emergen...
Morgan L Brown,Xuanyan Cai,M Celeste Simon
Morgan L Brown
Cancer cells require sufficient nutrients to support biomass generation, rapid proliferation, and survival. Thus, extensive reprogramming of amino acid metabolism is necessary for tumor initiation and progression under strenuous conditions....
Tumor-intrinsic dichotomy shapes cellular heterogeneity in pancreatic cancer [0.03%]
肿瘤内在的二分性塑造了胰腺癌的细胞异质性
Rebecca Diya Samuel,Shiv K Singh
Rebecca Diya Samuel
Intratumoral heterogeneity in pancreatic cancer poses a significant challenge, contributing to disease aggressiveness and complicating treatment. A recent study by Li et al. reveals that this heterogeneity is maintained by tumor-intrinsic r...
Emma L Pristo,Kelly M Hotchkiss,Anna M Corcoran et al.
Emma L Pristo et al.
Tumor-infiltrating lymphocyte (TIL) therapy has demonstrated efficacy in refractory melanoma and durable responses in lung cancer. Glioblastoma presents distinct challenges for immunotherapy, including profound tumor heterogeneity, low T ce...
IL17-producing γδ T cells promote radioresistance via immunosuppression [0.03%]
通过免疫抑制促进放射耐受的产生IL-17的γδT细胞
Lorenzo Galluzzi,Toni Celià-Terrassa
Lorenzo Galluzzi
IL17-secreting γδ T cells promote immunosuppression, metastatic dissemination, and resistance to treatment in various oncological settings. Recent findings from Deng et al suggest that DNA-containing extracellular vesicles released from i...
Gabriel J Starrett
Gabriel J Starrett
Human papillomavirus (HPV) integration is known to cause host genome instability and subsequent structural variants. Recently, Khan and colleagues thoroughly characterized a recurrent FGFR3-TACC3 fusion caused by HPV integration in orophary...
Connor D McKenney,Sergi Regot
Connor D McKenney
Whole-genome doubling (WGD) has recently emerged as one of the most common genomic alterations in cancer and is associated with genomic instability, drug resistance, and metastasis. However, WGD also generates unique vulnerabilities that cr...
Marie C Hasselluhn,Kenneth P Olive
Marie C Hasselluhn
RAS genes encode molecular switches that control cell growth and survival, and their oncogenic mutations drive many cancers. Once deemed 'undruggable', RAS is now being challenged by innovative inhibitors. Recent advances, reported by Stanl...