Caroline Donzé,Jean Yves Blay,Nicolas André
Caroline Donzé
Cytotoxic chemotherapy (CC) has long been the cornerstone of treatment in oncology, but primary resistance, the emergence of secondary resistance, and toxicity remain significant challenges. We explore how precision oncology aims to replace...
Mapping heterogeneity in the tumor microenvironment of renal cell carcinoma through single-cell omics [0.03%]
通过单细胞组学绘制肾细胞癌肿瘤微环境的异质性地图
Betul Gok Yavuz,Narmina Khanmammadova,Zuhair Majeed et al.
Betul Gok Yavuz et al.
Renal cell carcinoma (RCC) outcomes are shaped by a complex tumor microenvironment (TME), where malignant cells represent only a minority of the tissue. Recent advances in single-cell technologies - including single-cell RNA sequencing, sin...
Manuel Valiente,Carey Anders,Adrienne Boire et al.
Manuel Valiente et al.
Brain metastasis (BrM) represents the most common intracranial malignancy, arising in up to 30% of all adult cancer patients and contributing significantly to cancer-related morbidity and mortality. BrM is now recognized as a biologically d...
Canhui Cao
Canhui Cao
The serotonin transporter (SERT) and histone H3 serotonylation (H3Q5ser) integrate extracellular neurotransmitter signals to chromatin regulation in cancer. Here, we discuss how the SERT-H3Q5ser axis shapes tumor immunity and epigenetic pla...
Songhui Shin,Su Yeon Myoung,Hye Jin Cho et al.
Songhui Shin et al.
Tumors dynamically interact with the central and peripheral nervous systems, hijacking neural plasticity and reprogramming metabolism in a bidirectional manner to drive cancer progression. Neural inputs reshape the metabolism of cancer cell...
Xi Wang,Yilong Zou
Xi Wang
While the initial transformation of cancer cells is driven by genetic alterations, tumor cell behaviors and functional states are dynamically regulated by cell-intrinsic factors including proteins, metabolites and lipids, and extrinsic micr...
Functional plasticity of RNA-binding proteins in cancer: both friend and foe [0.03%]
RNA结合蛋白在癌症中的功能可塑性：敌亦是友
Lauren Harrison-Oakes,Wisdom Igiogbe,Diu T T Nguyen
Lauren Harrison-Oakes
RNA-binding proteins (RBPs) govern RNA-based post-transcriptional processes that generate the abundance and diversity of the proteome. RBPs have recently emerged as crucial cancer regulators that can influence multiple cancer hallmarks. How...
Ada Junquera,Anniina Färkkilä
Ada Junquera
Multi-omics integration is reshaping cancer research by combining histopathology, transcriptomics, and proteomics with spatial and temporal context. Schweizer et al. revealed compartment-specific biology, RNA-protein decoupling, and emergen...
Morgan L Brown,Xuanyan Cai,M Celeste Simon
Morgan L Brown
Cancer cells require sufficient nutrients to support biomass generation, rapid proliferation, and survival. Thus, extensive reprogramming of amino acid metabolism is necessary for tumor initiation and progression under strenuous conditions....
Tumor-intrinsic dichotomy shapes cellular heterogeneity in pancreatic cancer [0.03%]
肿瘤内在的二分性塑造了胰腺癌的细胞异质性
Rebecca Diya Samuel,Shiv K Singh
Rebecca Diya Samuel
Intratumoral heterogeneity in pancreatic cancer poses a significant challenge, contributing to disease aggressiveness and complicating treatment. A recent study by Li et al. reveals that this heterogeneity is maintained by tumor-intrinsic r...