Zihan Xia,Olivier De Wever
Zihan Xia
The plasticity of cancer-associated fibroblasts (CAFs) refers to their ability to adopt a spectrum of distinct phenotypes or states in response to dynamic changes within the tumor microenvironment (TME). Recent advances in single-cell techn...
Jessica L Chitty,Thomas R Cox
Jessica L Chitty
Significant advances in matrix biology research have enhanced our understanding of individual matrix components and extracellular matrix (ECM) signalling. The dysregulation of the ECM during the development of solid tumours is a critical ar...
Treatment of patients with pMMR GI cancers with tumor-infiltrating lymphocytes (TIL): a reality? [0.03%]
用肿瘤浸润淋巴细胞(TIL)治疗pMMR消化道癌症患者：一种现实的方法吗？
John B Haanen
John B Haanen
A recent study published in Nature Medicine shows that adoptive cell therapy using neoantigen-selected tumor-infiltrating lymphocytes (TIL) is feasible in refractory metastatic gastrointestinal (GI) cancers, showing durable responses, espec...
Immunocytokines and cytokine neutralization for cancer immunotherapy [0.03%]
用于癌症免疫治疗的免疫细胞因子和细胞因子中和抗体疗法
Pedro Berraondo,Raquel Cuesta,Fernando Aranda et al.
Pedro Berraondo et al.
Despite deep and growing knowledge of cytokine functions, immunotherapies based on the control of these molecules have minimally impacted cancer patient management because of limited efficacy and narrow therapeutic windows. Opportunities to...
Yuefan Wang,Ramon U Jin,Joanne Xu et al.
Yuefan Wang et al.
Gastric cancer arises from complex carcinogenic factor interactions, with limited treatment options due to the lack of targetable driver gene mutations and significant tumor heterogeneity. Recent studies have provided promising novel approa...
Prospects for understanding and exploiting the consequences of hyperactivation lethality [0.03%]
探究超活化致死性的后果及其利用前景
Katharin Shaw,René Bernards,Kimberly Stegmaier et al.
Katharin Shaw et al.
Cancer cells optimize oncogenic signaling to maintain a defined range for survival. The success of targeted therapeutic inhibitors is based on suppressing signaling below this optimal fitness zone. Conversely, cancers are also susceptible t...
Ayoub Jaa,Aitziber Buque
Ayoub Jaa
The tumor microenvironment (TME) comprises heterogeneous cell types that closely interact with each other. Crosstalk among the TME components determines antitumor immune responses and their sensitivity to therapies such as immunotherapy. Re...
Early immune evasion in colorectal cancer: interplay between stem cells and the tumor microenvironment [0.03%]
结直肠癌早期免疫逃逸：干细胞与肿瘤微环境的相互作用
Norihiro Goto,Judith Agudo,Ömer H Yilmaz
Norihiro Goto
Most colorectal cancers (CRCs) are characterized by a low mutational burden and an immune-cold microenvironment, limiting the efficacy of immune checkpoint blockade (ICB) therapies. While advanced tumors exhibit diverse immune evasion mecha...
Michaela Luconi,Giulia Cantini,Clara Crescioli
Michaela Luconi
The acknowledged relationship between metabolism and cancer retains important potential as a novel target in therapy. Reallocating glucose-lowering drugs (GLDs) in cancer treatment offers valuable perspectives for the ability of these molec...
Daehee Hwang,Whitney S Henry
Daehee Hwang
Despite significant milestones in cancer immunotherapy, tumor cells often escape immune surveillance. Zhou et al. revealed that the pivotal ferroptosis suppressor glutathione peroxidase 4 (GPX4) can undergo palmitoylation by zDHHC8, enhanci...