Novel role of Quercetin in ameliorating metabolic syndrome via VDR mediated activation of adiponectin/AdipoR2 signaling [0.03%]
檞皮素通过维生素D受体介导的脂联素/脂联素受体2信号改善代谢综合征的新机制
Nirmala G Sannappa Gowda,Varsha D Shiragannavar,Shreyas H Karunakara et al.
Nirmala G Sannappa Gowda et al.
A sedentary lifestyle and physical inactivity leads to metabolic syndrome-associated comorbidities involving abdominal obesity, type 2 diabetes, hyperlipidaemia associated Cardiovascular Diseases (CVDs), and Metabolic dysfunction-associated...
Increased levels of thymidine kinase 1 in malignant cell-derived extracellular vesicles [0.03%]
恶性细胞源外泌体中胸苷激酶1水平升高
Ehsan Manouchehri Doulabi,Louise Dubois,Liza Löf et al.
Ehsan Manouchehri Doulabi et al.
Extracellular vesicles (EVs), whose main subtypes are exosomes, microparticles, and apoptotic bodies, are secreted by all cells and harbor biomolecules such as DNA, RNA, and proteins. They function as intercellular messengers and, depending...
Biochemical characterization of a unique cytokinin and nucleotide phosphoribohydrolase Lonely Guy protein from Dictyostelium discoideum [0.03%]
Dictyostelium discoideum中独特的植物激素类细胞激动素和核苷酸焦磷酸酶/吡rophosphate酶“孤独男士”蛋白的生化鉴定
Megan M Aoki,Anna B Kisiala,Scott C Farrow et al.
Megan M Aoki et al.
Lonely guy (LOG) proteins are phosphoribohydrolases (PRHs) that are key cytokinin (CK)-activating enzymes in plant and non-plant CK-producing organisms. During CK biosynthesis, LOGs catalyze the conversion of precursor CK-nucleotides (CK-NT...
Ovarian cancer ascites proteomic profile reflects metabolic changes during disease progression [0.03%]
卵巢癌腹水蛋白质谱反映了疾病进展过程中的代谢变化
Diana Luísa Almeida-Nunes,Mariana Nunes,Hugo Osório et al.
Diana Luísa Almeida-Nunes et al.
Ovarian cancer (OC) patients develop ascites, an accumulation of ascitic fluid in the peritoneal cavity anda sign of tumour dissemination within the peritoneal cavity. This body fluid is under-researched, mainly regarding the ascites formed...
Development of an ancestral DC and TLR4-inducing multi-epitope peptide vaccine against the spike protein of SARS-CoV and SARS-CoV-2 using the advanced immunoinformatics approaches [0.03%]
基于先进的免疫信息学方法针对SARS-CoV和SARS-CoV-2刺突蛋白开发具有诱导古典型DC和TLR4的多表位肽疫苗
Cena Aram,Parsa Alijanizadeh,Kiarash Saleki et al.
Cena Aram et al.
The oldest human coronavirus that started pandemics is severe acute respiratory syndrome virus (SARS-CoV). While SARS-CoV was eradicated, its new version, SARS-CoV2, caused the global pandemic of COVID-19. Evidence highlights the harmful ev...
Distinct biological characteristics of mesenchymal stem cells separated from different components of human placenta [0.03%]
来源于不同的人胎盘组分的间充质干细胞具有不同的生物学特性
Xiangxiong Deng,Su Zhang,Quan Qing et al.
Xiangxiong Deng et al.
Mesenchymal stem cells (MSCs) have tremendous potential in cell therapy and regenerative medicine. The placenta-derived MSCs (PMSCs) are becoming favorable sources as they are ethically preferable and rich in MSCs. Although several subgroup...
Evaluation of the antiviral activity of new dermaseptin analogs against Zika virus [0.03%]
新型 Dermaseptin 类化合物的抗病毒活性评价及其对寨卡病毒的作用机制研究
Houda Haddad,Frédéric Tangy,Ines Ouahchi et al.
Houda Haddad et al.
Zika virus represents the primary cause of infection during pregnancy and can lead to various neurological disorders such as microcephaly and Guillain-Barré syndrome affecting both children and adults. This infection is also associated wit...
Generation of monoclonal antibody against 6-Keto PGF1α and development of ELISA for its quantification in culture medium [0.03%]
抗6-酮-PGF1α单克隆抗体的研制及培养液中6-酮-PGF1α的酶联免疫测定方法的发展
Md Mazharul Islam Chowdhury,Nafisa Kabir,Rezwana Ahmed et al.
Md Mazharul Islam Chowdhury et al.
Prostacyclin or prostaglandin I2 (PGI2), a metabolite of arachidonic cyclooxygenase pathway, has been demonstrated as an effector of adipocyte differentiation. However, due to its instability in biological fluid, it is difficult to evaluate...
Qi Liu,Liang Yue,Jiu Deng et al.
Qi Liu et al.
The three-dimensional (3D) kidney organoid is a breakthrough model for recapitulating renal morphology and function in vitro, which is grown from stem cells and resembles mammalian kidney organogenesis. Currently, protocols for cultivating ...
Role of FFAR3 in ketone body regulated glucagon-like peptide 1 secretion [0.03%]
FFAR3在酮体调节胰高血糖素样肽1分泌中的作用
Sara Mt Persson,Anna Casselbrant,Aiham Alarai et al.
Sara Mt Persson et al.
Background: Roux-en-Y gastric bypass (RYGB) is an effective treatment for obesity, resulting in long-term weight loss and rapid remission of type 2 diabetes mellitus. Improved glucagon-like peptide 1 (GLP-1) levels is one...