Ramtin Pourahmad,Kiarash Saleki,Mehrad Zare Gholinejad et al.
Ramtin Pourahmad et al.
Alzheimer's disease (AD) is the most widespread and irreversible form of dementia and accounts for more than half of dementia cases. The most significant risk factors for AD are aging-related exacerbations, degradation of anatomical pathway...
Relationship between oligoarginine-induced membrane damage of single Escherichia coli cells and entry of the peptide into the cytoplasm [0.03%]
寡精氨酸引起单个大肠杆菌细胞膜损伤与其肽进入胞浆之间的关系
Sabrina Sharmin,Md Zahidul Islam,Masahito Yamazaki
Sabrina Sharmin
Cell-penetrating peptides (CPPs) can enter the cytosol of eukaryotic cells without killing them whereas some CPPs exhibit antimicrobial activity against bacterial cells. Here, to elucidate the mode of interaction of the CPP nona-arginine (R...
Proteasome and PARP1 dual-target inhibitor for multiple myeloma: Fluzoparib [0.03%]
PROTACs蛋白酶体及PARP1双靶点抑制剂氟卓泊帕IBUTRAZATICMP207在治疗多发性骨髓瘤中的应用研究
Kai Deng,Qiongqiong Li,Lina Lu et al.
Kai Deng et al.
One of the current mainstream treatments for multiple myeloma (MM) is chemotherapy. However, due to the high clonal heterogeneity and genomic complexity of MM, single-target drugs have limited efficacy and are prone to drug resistance. Ther...
Israel Canela-Pérez,Elisa Azuara-Liceaga,Patricia Cuéllar et al.
Israel Canela-Pérez et al.
Entamoeba histolytica is a protozoan parasite that belongs to the Amoebozoa supergroup whose study related to the nucleocytoplasmic transport of proteins through the nucleus is poorly studied. In this work, we have performed in silico predi...
In silico identification of putative druggable pockets in PRL3, a significant oncology target [0.03%]
计算识别潜在可药物化的PRL3蛋白位点用于显著的肿瘤学目标研究
Grace M Bennett,Julia Starczewski,Mark Vincent C Dela Cerna
Grace M Bennett
Protein tyrosine phosphatases (PTP) have emerged as targets in diseases characterized by aberrant phosphorylations such as cancers. The activity of the phosphatase of regenerating liver 3, PRL3, has been linked to several oncogenic and meta...
Proteolysis of mitochondrial calpain-13 in cerebral ischemia-reperfusion injury [0.03%]
脑缺血再灌注损伤中的线粒体钙蛋白酶-13的降解
Yusaku Chukai,Toru Sudo,Tomokazu Fukuda et al.
Yusaku Chukai et al.
Calpains are calcium-dependent cysteine proteases activated by intracellular Ca2+. Although calpains mainly exist in the cytosol, calpain-13 is present in the mitochondria in mouse brains; however, the enzymatic properties and physiological...
Development of a formula for scoring competence of bovine embryos to sustain pregnancy [0.03%]
一种评价牛胚胎维持妊娠能力的打分体系的研究
Maria Belen Rabaglino,Peter J Hansen
Maria Belen Rabaglino
Embryo transfer in cattle and other species is a key reproductive technology to improve genetic merit. However, pregnancy loss after embryo transfer is still a major barrier to optimal utilization of the technology. Furthermore, the lack of...
Splenocytes and thymocytes migration patterns between lymphoid organs in pregnancy [0.03%]
妊娠期间淋巴器官间的脾细胞和胸腺细胞迁移模式
Gabriela T Cruz-Cureño,Marina Ch Rosales-Tarteaut,Lourdes A Arriaga-Pizano et al.
Gabriela T Cruz-Cureño et al.
Background: Cell migration is essential for the immune system and is frequently analyzed in adult non-pregnant animals but poorly explored in pregnant animals. However, a physiologic increased size in the spleen and peria...
CRISPR/Cas9 technology in the modeling of and treatment of mucopolysaccharidosis [0.03%]
CRISPR/Cas9技术在黏多糖贮积症研究和治疗中的应用
Mehran Reyhani-Ardabili,Soudeh Ghafouri-Fard
Mehran Reyhani-Ardabili
Mucopolysaccharidosis (MPS) syndromes are a group of heterogeneous genetic disorders in terms of genetic basis and clinical manifestations, ranging from mild to fatal forms. There are a number of applied or prospective treatment modalities ...
Smoking-induced suppression of β-casein in milk is associated with an increase in miR-210-5p expression in mammary epithelia [0.03%]
吸烟诱导的乳汁β-酪蛋白抑制与乳腺上皮中miR-210-5p表达增加有关
Takeshi Chiba,Akira Takaguri,Toshiyasu Mikuma et al.
Takeshi Chiba et al.
Smoking during lactation harmfully affects the amount and constituents of breast milk. Infants who consume breast milk containing miR-210-5p may have a higher risk of brain-related diseases. We investigated whether smoking during lactation ...