Changing the gravity vector direction by inverted culture enhances radiation-induced cell damage [0.03%]
倒置培养改变重力矢量方向增强辐射对细胞的损伤作用
Yuma Mizoguchi,Masao Kamimura,Kazuki Kitabatake et al.
Yuma Mizoguchi et al.
In recent years, it has become clear that the cytotoxicity of γ-irradiation of cells is increased under microgravity conditions. However, there has been no study of the effect of the gravity vector direction, rather than the magnitude, on ...
Heterologous expression, characterization, and application of recombinant thermostable α-amylase from Geobacillus sp. DS3 for porous starch production [0.03%]
地芽胞杆菌DS3异源表达、性质表征及淀粉酶在多孔淀粉生产中的应用
Dina Clarissa Kurniawan,Muhammad Saifur Rohman,Lucia Dhiantika Witasari
Dina Clarissa Kurniawan
Novel Geobacillus sp. DS3, isolated from the Sikidang Crater in Dieng, exhibits promising characteristics for industrial applications, particularly in thermostable α-amylase production. Recombinant technology was used to express thermostab...
In vitro osteoclast differentiation enhanced by hepatocyte supernatants from high-fat diet mice [0.03%]
高脂饮食小鼠肝细胞上清液通过体外实验促进破骨细胞性分化增强效应研究
Yan Wang,Fangli Zhou,Siyi Shu et al.
Yan Wang et al.
Non-alcoholic fatty liver disease (NAFLD) is associated with abnormal bone metabolism, potentially mediated by elevated levels of proinflammatory cytokines such as tumor necrosis factor alpha (TNF-ɑ) and interleukin 6 (IL-6). This study ai...
Cxcr4a regulates heart progenitor development and cardiac rhythm in zebrafish [0.03%]
Cxcr4a调控斑马鱼心脏祖细胞发育及心律
Bingyu Chen,Qin Ran,Xin Chen et al.
Bingyu Chen et al.
Cxcr4a is involved in multiple organ development including coronary vasculature formation and heart left-right (LR) patterning, whether it is involved in heart progenitor determination and cardiac rhythm regulation is not addressed. Here we...
Identification of hub lncRNAs correlated with tetralogy of fallot based on weighted gene co-expression network analysis [0.03%]
基于加权基因共表达网络分析的法洛四联症相关hub长链非编码RNA识别研究
Ye Ding,Chun Zhu
Ye Ding
The most prevalent cyanotic congenital heart disease, Tetralogy of Fallot (TOF), has an unknown etiology. Long-stranded non-coding RNAs (lncRNAs) have been linked to cardiac development and congenital heart disease, as evidenced by an incre...
In silico and ADMET molecular analysis targeted to discover novel anti-inflammatory drug candidates as COX-2 inhibitors from specific metabolites of Diospyros batokana (Ebenaceae) [0.03%]
基于硅基和ADME/tox的分子分析，从冬青科大柯梾属种特定代谢物中发现新型抗炎药物候选者作为COX-2抑制剂的研究
Bitwell Chibuye,Indra Sen Singh,Luke Chimuka et al.
Bitwell Chibuye et al.
Diospyros batokana (Ebenaceae) is a valuable medicinal plant that grows in the wild in Zambia. The aqua crude plant extract is valuable in treating oxidative stress and microbes-related diseases. In this study, bioactive metabolites from th...
Expression of opsin and visual cycle-related enzymes in fetal rat skin keratinocytes and cellular response to blue light [0.03%]
大鼠胎皮肤角质细胞中视蛋白和视觉周期相关酶的表达及角质形成细胞对蓝光的反应
Hiroyuki Yamamoto,Momo Okada,Yoshikazu Sawaguchi et al.
Hiroyuki Yamamoto et al.
The mechanism by which the skin, a non-visual tissue, responds to light remains unknown. To date, opsin expression has been demonstrated in keratinocytes, melanocytes, and fibroblasts, all of which are skin-derived cells. In this study, we ...
A non-invasive screening method using Caenorhabditis elegans for early detection of multiple cancer types: A prospective clinical study [0.03%]
一种使用秀丽隐杆线虫检测多种癌症类型的非侵入式筛查方法的前瞻性临床研究
Hideyuki Hatakeyama,Masayo Morishita,Aya Hasan Alshammari et al.
Hideyuki Hatakeyama et al.
Cancer is the second leading cause of death worldwide, according to the World Health Organization, surpassed only by cardiovascular diseases. Early identification and intervention can significantly improve outcomes. However, finding a unive...
Involvement of lipid-translocating exporter family proteins in determination of myriocin sensitivity in budding yeast [0.03%]
芽胞酵母菌中脂肪质转运蛋白在外源性生物碱myriocin敏感性决定中的作用
Takahiro Kawaguchi,Yohei Ishibashi,Momoko Matsuzaki et al.
Takahiro Kawaguchi et al.
Myriocin is an inhibitor of serine palmitoyltransferase involved in the initial biosynthetic step for sphingolipids, and causes potent growth inhibition in eukaryotic cells. In budding yeast, Rsb1, Rta1, Pug1, and Ylr046c are known as the L...
Characterization of high-affinity antibodies against the surface Gc protein of Dabie bandavirus / severe fever with thrombocytopenia syndrome virus [0.03%]
特异性识别 dabie山病毒/严重发热伴血小板减少综合征病毒 表面Gc蛋白的高效价抗体鉴定
Pyeonghwa Jeon,Bin Yoo,Yoonji Kim et al.
Pyeonghwa Jeon et al.
Severe fever with thrombocytopenia syndrome virus (SFTSV) or Dabie bandavirus is an emerging pathogen responsible for SFTS. It is considered a novel threat to human health, given the high associated fatality. SFTSV is a segmented negative-s...