The constant domain of CRTAM is essential for high-affinity interaction with Nectin-like 2 [0.03%]
CRTAM恒定区对于与nectin样蛋白2高亲和力相互作用的必不可少性
Juan Carlos Barragan-Galvez,Araceli Hernandez-Flores,Orestes Lopez-Ortega et al.
Juan Carlos Barragan-Galvez et al.
CRTAM (Class-I MHC restricted T cell-associated molecule) is a member of the Nectin-like family, composed of two extracellular domains, one constant domain (IgC) and another variable domain (IgV), expressed in activated CD8 T cells, epithel...
Targeting iRhom2/ADAM17 attenuates COVID-19-induced cytokine release from cultured lung epithelial cells [0.03%]
靶向iRhom2/ADAM17可减轻新冠病毒引起的肺上皮细胞中细胞因子的释放
Vitoria Mattos Pereira,Amit Thakar,Sreejayan Nair
Vitoria Mattos Pereira
The COVID-19 pandemic, caused by SARS-CoV-2, continues to pose a significant global health challenge, with acute respiratory distress syndrome (ARDS) being a major cause of mortality. Excessive cytokine release (cytokine storm) has been cau...
The antimicrobial peptide Temporin-L induces vesicle formation and reduces the virulence in S. aureus [0.03%]
抗菌肽Temporin-L诱导金黄色葡萄球菌形成小泡并降低其毒力
Carolina Canè,Noemi Gallucci,Angela Amoresano et al.
Carolina Canè et al.
The evolution of methicillin-resistant Staphylococcus aureus (MRSA) has required the development of new antimicrobial agents and new approaches to prevent and overcome drug resistance. AntiMicrobial Peptides (AMPs) represent promising alter...
Eggshell membrane and its major component lysozyme and ovotransferrin enhance the secretion of decorin as an endogenous antifibrotic mediator from lung fibroblasts and ameliorate bleomycin-induced pulmonary fibrosis [0.03%]
蛋壳膜及其主要成分溶菌酶和卵转铁蛋白可增强成纤维细胞分泌抗纤维化内源性介导因子 decorin 并改善顺铂诱导的肺纤维化
Eri Ohto-Fujita,Miho Shimizu,Aya Atomi et al.
Eri Ohto-Fujita et al.
Aging is a high-risk factor for obstructive and fibrotic lung diseases. Fibrotic lung disease leading to decreased lung function is characterized by interstitial remodeling and tissue scarring (sclerosis), with destruction of alveoli and ex...
Human Antigen R -mediated modulation of Transforming Growth Factor Beta 1 expression in retinal pathological milieu [0.03%]
人抗原R介导的转化生长因子β1在视网膜病理微环境中的表达调节
Sruthi Priya Mohan,Hemavathy Nagarajan,Umashankar Vetrivel et al.
Sruthi Priya Mohan et al.
The fate and stability of messenger RNA (mRNA), from transcription to degradation is regulated by a dynamic shuttle of epigenetic modifications and RNA binding proteins in maintaining healthy cellular homeostasis and disease development. Wh...
Differential effects of TLR3 and TLR4 activation on MSC-mediated immune regulation [0.03%]
TLR3和TLR4活化对间充质干细胞免疫调节功能的差异化影响
Urvashi Kaundal,Aruna Rakha
Urvashi Kaundal
Mesenchymal stromal cells (MSCs) have evolved as an invaluable therapeutic cell type due to their broad therapeutic properties. Bone marrow-derived MSCs are currently being applied in numerous clinical trials, and the initial results have b...
Understanding alpha-synuclein aggregation propensity in animals and humans [0.03%]
人和动物中α-突触核蛋白聚集倾向性的研究
Natalie G Horgan,Annie M McCarty,Ashley A Hetak et al.
Natalie G Horgan et al.
Alpha-synuclein (α-syn) aggregation plays a critical role in the pathogenicity of Parkinson's Disease (PD). This study aims to evaluate the aggregation propensity of α-syn fragment peptides designed using the variability found in humans a...
In s ilico assessment of hesperidin on SARS-CoV-2 main protease and RNA polymerase: Molecular docking and dynamics simulation approach [0.03%]
基于分子对接和动力学模拟的柚皮素作用于SARS-CoV-2主要蛋白酶和RNA聚合酶的体外评估研究
Elaheh Molaakbari,Mohammad Reza Aallae,Fereshteh Golestanifar et al.
Elaheh Molaakbari et al.
The present study uses molecular docking and dynamic simulations to evaluate the inhibitory effect of flavonoid glycosides-based compounds on coronavirus Main protease (Mpro) and RNA polymerase. The Molegro Virtual Docker (MVD) software is ...
Engineered mouse H1 promoter mutants with superior RNA polymerase III activity [0.03%]
具有更优的RNA聚合酶III活性的工程鼠H1启动子变异体
Jiaying Wu,Yufei Zhou,Di Zhao et al.
Jiaying Wu et al.
Vectors incorporating the human H1 (hH1) promoter are being applied for RNA interference (RNAi) experiments and genome editing. Although extensive studies have been conducted on the hH1 promoter, our understanding of the mouse H1 promoter r...
Assessment of waterlogging-induced changes in enzymatic antioxidants and carbohydrate metabolism in peanuts genotypes [0.03%]
淹水对不同花生品种抗氧化酶和糖代谢影响的研究
Shubhangani Sharma,Upma Bhatt,Garishma Shah et al.
Shubhangani Sharma et al.
Soil flooding, manifesting as submergence or waterlogging stress, significantly impacts plant species composition and agricultural productivity, particularly in regions with low rainfall. This study investigates the biochemical responses of...