Genomic insights into the tunicamycin-induced endoplasmic reticulum stress response in peripheral blood mononuclear cells: A comprehensive RNA sequencing analysis [0.03%]
外周血单个核细胞中tümcycin诱导的内质网应激反应的基因组学见解：全面的RNA序列分析
Laura S Mahl,Axel H Meyer
Laura S Mahl
Tunicamycin induces endoplasmic reticulum (ER) stress by inhibiting N-glycosylation of newly synthesized proteins, leading to accumulation of misfolded proteins in the ER. This activates the unfolded protein response (UPR), a conserved adap...
Integrative single-cell and bulk transcriptomic analysis identifies lesion-associated gene signatures for prognostic stratification and therapeutic guidance in head and neck squamous cell carcinoma [0.03%]
整合单细胞和bulk转录组分析鉴定头颈鳞癌病灶相关基因标志物用于预后分层和指导治疗
Meihua Xiong,Yong Luo,Shiping Hu
Meihua Xiong
Background: Head and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous malignancy with poor prognosis and variable response to therapy. Effective biomarkers for prognosis and treatment guidance remain limited...
Exendin-4 protects brain endothelial cell damage against hyperammonemic condition [0.03%]
Exendin-4保护高血氨引起的脑内皮细胞损伤
Seo Yeon Ahn,Danbi Jo,Seo Yoon Choi et al.
Seo Yeon Ahn et al.
Hepatic encephalopathy (HE) is a neuropsychiatric disorder associated with elevated ammonia levels, which impair blood-brain barrier (BBB) integrity and trigger chronic neuroinflammation. This study aims to evaluate the therapeutic potentia...
Integrating CRISPR genome editing with liver organoid and hiPSC-derived microfluidic platforms to model metabolic dysfunction-associated steatotic liver disease [0.03%]
结合类器官和hiPSC来源的微流控平台，利用CRISPR基因编辑技术模拟与代谢紊乱相关的脂肪变性肝病
Aina Kehinde Oluwasegun
Aina Kehinde Oluwasegun
Metabolic dysfunction-associated steatotic liver disease (MASLD) and its progressive form, metabolic dysfunction-associated steatohepatitis (MASH), arise from the interplay of genetic susceptibility, metabolic stress, and multicellular hepa...
Region-specific microglial alterations in the acoustic startle circuit in Shank3 mice [0.03%]
Shank3基因突变小鼠听性惊跳反射环路中地区特异性的微胶质细胞变化
Xin Ren,Robbert Havekes,Martien J H Kas
Xin Ren
Autism spectrum disorder (ASD) encompasses a diverse range of neurodevelopmental conditions characterized by variations in social interactions, stereotyped behaviors, and sensory processing differences. Altered tactile and auditory sensory ...
Chronic high-fat diet decreases global histone H4 acetylation and increases HDAC8 expression in mouse testes [0.03%]
高脂饮食通过降低雄鼠睾丸组蛋白H4乙酰化和增加HDAC8表达诱导雄性生殖毒性
Shu Aizawa,Hikari Ohno,Yutaka Yamamuro
Shu Aizawa
Obesity is a major public health problem and a risk factor for metabolic disorders, including type 2 diabetes and cardiovascular disease. Additionally, accumulating evidence suggests that obesity impairs male reproductive capacity, potentia...
Deletion of TOP2B promoter using CRISPR-Cas9 induces senescence in HEK 293T cells [0.03%]
CRISPR-Cas9诱导HEK 293T细胞TOP2B启动子缺失导致衰老
Neha Saroj,Harshitha Golagana Velangani,Shashi Kiran et al.
Neha Saroj et al.
DNA topoisomerase II beta (TOP2B) is crucial for the regulation of DNA topology, transcription, and genome stability. While its function has been extensively studied in post-mitotic cells such as neurons and cardiomyocytes, its role in prol...
Drug repositioning in metastatic prostate cancer based on protein- protein interaction network: Computational and in vitro analysis [0.03%]
基于蛋白质相互作用网络的去势抵抗性前列腺癌药物再定位研究：计算与实验分析
Zakie Saadat,Seyed Mahdi Ahmadi,Mohammad Javad Bazyari et al.
Zakie Saadat et al.
Metastasis is a big challenge for prostate cancer patients that reduces their overall survival from 98.2% to 30%. Therefore, it is important to find the underlying mechanism driving metastasis and find a drug that can prevent cell invasion,...
Transcriptomic and alternative splicing reprogramming by low-dose gamma irradiation in tomato under ToBRFV infection [0.03%]
低剂量γ射线辐照重编程番茄感染ToBRFV后的转录组和可变剪接
Abozar Ghorbani,Mahsa Rostami,Davoud Koolivand
Abozar Ghorbani
Tomato brown rugose fruit virus (ToBRFV) is a rapidly spreading pathogen that threatens global tomato production by overcoming established genetic resistance mechanisms. Conventional seed disinfection strategies often fail to eliminate the ...
Small molecules promote the in vitro expansion and passaging of adult mouse pancreatic islets [0.03%]
小分子促进成年鼠胰岛体外扩增和传代
Lingxian Zhang,Kairui Liu,Xiaoxiao Zhang et al.
Lingxian Zhang et al.
Islet-like organs can provide a new solution for the treatment of diabetes and personalized drug testing. However, because adult pancreatic tissue lacks regenerative capacity, it is still not possible to expand islet clusters from adult mic...