Recent advances in aptamer discovery, modification and improving performance [0.03%]
近年抗体发现、修饰及提高性能的进展
Arezoo Fallah,Abbas Ali Imani Fooladi,Seyed Asghar Havaei et al.
Arezoo Fallah et al.
Aptamers are nucleic acid (Ribonucleic acid (RNA) and single strand deoxyribonucleic acid (ssDNA)) with a length of approximately 25-80 bases that can bind to particular target molecules, similar to monoclonal antibodies. Due to their many ...
Dynamic strain and β-catenin mediated suppression of interferon responsive genes in quiescent mesenchymal stromal/stem cells [0.03%]
静止状态下间充质基质/干细胞中的动态应变和β-连环蛋白介导的干扰素响应基因抑制作用
Parisa Dashti,Eric A Lewallen,Gary S Stein et al.
Parisa Dashti et al.
Multipotent bone marrow mesenchymal stromal/stem cells (MSCs) respond to mechanical forces. MSCs perceive static and dynamic forces through focal adhesions, as well as cytoskeletal and intranuclear actin. Dynamic strain stimulates nuclear ...
Modifications in the C-terminal tail of TrkC significantly alter neurotrophin-3-promoted outgrowth of neurite-like processes from PC12 cells [0.03%]
TrkC蛋白C末端尾巴的突变显著影响神经营养因子nt-3诱导PC12细胞神经突起的伸长
Pawel Krawczyk,Dagmara Klopotowska,Janusz Matuszyk
Pawel Krawczyk
TrkB and TrkC are quite common neurotrophin receptors found on the same cells in CNS. In the C-terminal tail, TrkB and TrkC differ only in two amino acid residues at positions immediately preceding the tyrosine residue, which, upon phosphor...
An in-silico approach to target multiple proteins involved in anti-microbial resistance using natural compounds produced by wild mushrooms [0.03%]
利用野生蘑菇产生的天然化合物靶向抗菌药物耐药性相关蛋白的计算机方法
Gagandeep Singh,Md Alamgir Hossain,Dhurgham Al-Fahad et al.
Gagandeep Singh et al.
Bacterial resistance to antibiotics and the number of patients infected by multi-drug-resistant bacteria have increased significantly over the past decade. This study follows a computational approach to identify potential antibacterial comp...
A diet high in glucose and deficient in dietary fibre causes fat accumulation in the liver without weight gain [0.03%]
高糖低膳食纤维饮食可导致肝脏脂肪蓄积且不伴随体重增加
Sonoko Karino,Haruki Usuda,Shoma Kanda et al.
Sonoko Karino et al.
This study investigated whether a standard calorie diet that is high in glucose and deficient in dietary fibre (described as HGD [high glucose diet]) induces hepatic fat accumulation in mice. We evaluated hepatic steatosis at 7 days and 14 ...
Identification of genes related to fatty acid metabolism in type 2 diabetes mellitus [0.03%]
2型糖尿病相关脂肪酸代谢基因的识别
Ji Yang,Yikun Zhou,Jiarui Zhang et al.
Ji Yang et al.
Aim: Fatty acid metabolism is pivotal for lipid synthesis, cellular signaling, and maintaining cell membrane integrity. However, its diagnostic significance in type 2 diabetes mellitus (T2DM) remains unclear. ...
Impact of T-2 toxin on intestinal inflammation and transcriptional regulation of inflammatory response in mouse macrophages [0.03%]
T-2毒素对小鼠肠巨噬细胞炎症及促炎转录调控的影响
Xinghui Yang,Xiaoli Xu,Qiuhong Zhong et al.
Xinghui Yang et al.
T-2 toxin, a fungal secondary metabolite produced by toxigenic Fusarium species, poses a significant threat to grain food and feed due to its potential to cause intestinal inflammation in livestock and poultry. Macrophages play a crucial ro...
Laura Doro,Alessandra T Peana,Rossana Migheli et al.
Laura Doro et al.
Oxidative stress and inflammation are responsible for endothelial damage displaying many sex differences. Lipopolysaccharide (LPS) is a pathogenic stimulus that can trigger inflammation, contributing to endothelial dysfunction. Given the sc...
Label-based comparative proteomics of oral mucosal tissue to understand progression of precancerous lesions to oral squamous cell carcinoma [0.03%]
基于标签的比较蛋白质组学研究口腔粘膜组织以了解癌前病变向鳞状细胞癌的发展过程
Vipra Sharma,Sundararajan Baskar Singh,Sabyasachi Bandyopadhyay et al.
Vipra Sharma et al.
Introduction: Oral squamous cell carcinomas typically arise from precancerous lesions such as leukoplakia and erythroplakia. These lesions exhibit a range of histological changes from hyperplasia to dysplasia and carcinom...
Identification of cell wall binding domains and repeats in Streptococcus pneumoniae phage endolysins: A molecular and diversity analysis [0.03%]
肺炎链球菌噬菌体内溶酶细胞壁结合结构域和重复序列的鉴定及分子多样性分析
Tahsin Khan,Shakhinur Islam Mondal,Araf Mahmud et al.
Tahsin Khan et al.
Streptococcus pneumoniae (pneumococcus) is a multidrug-resistant pathogen associated with pneumonia, otitis media, meningitis and other severe complications that are currently a global threat to human health. The World Health Organization l...