NOS3 regulates angiogenic potential of human induced pluripotent stem cell-derived endothelial cells [0.03%]
NOS3调节人诱导多能干细胞源内皮细胞的血管生成潜力
Anne M Kong,Zulhusni A Idris,Daniel Urrutia-Cabrera et al.
Anne M Kong et al.
Incorporation of blood capillaries in engineered tissues and their functional connection to host blood vessels is essential for success in engineering vascularized tissues, a process which involves spatial patterning of endothelial cells (E...
Structural modeling of phosphatidylinositol 3-kinase-γ with novel derivatives of stilbenoids [0.03%]
茋类衍生物磷脂酰肌醇3-激酶-γ结构模型的构建与分析
Sagar Rathee,Madhan Vishal Rajan,Simran Sharma et al.
Sagar Rathee et al.
Phosphatidylinositol 3-kinases (PI3K) form a family of lipid kinases that catalyze the phosphorylation of 3-hydroxyl group of the inositol ring of phosphatidylinositol and its derivatives. It is implicated in inflammatory disorders and canc...
Design of a novel multi-epitope vaccine candidate against Yersinia pestis using advanced immunoinformatics approaches: An in silico study [0.03%]
一种用于设计耶尔森氏鼠疫杆菌多表位疫苗的新方法：基于免疫信息学的体外研究
Mohamed J Saadh,Hanan Hassan Ahmed,Radhwan Abdul Kareem et al.
Mohamed J Saadh et al.
Yersinia pestis is the perilous pandemics that occurred in Asia and Europe. The bacterium has shown drug resistance that can cause the future pandemic and destroy the drug treatment against plague. As known, effective therapeutics such as d...
Application of liposomal nanoparticles of berberine in photodynamic therapy of A549 lung cancer spheroids [0.03%]
小檗碱脂质纳米粒在A549肺癌类球体光动力治疗中的应用研究
Kave Moloudi,Heidi Abrahamse,Blassan P George
Kave Moloudi
Application of liposomes is a critical strategy in drug delivery and increase cellular uptake of drugs having low water solubility. Berberine (BBR) is a bioactive compound found in several plants, including Goldenseal, Barberry, and Oregon ...
StarD5 modulates B cell cholesterol synthesis and IgG1 plasma cell differentiation [0.03%]
星D5调节B细胞胆固醇合成和IgG1浆细胞分化
Anuj Tharakan,Daniel Rodriguez-Agudo,Sheela Damle et al.
Anuj Tharakan et al.
StarD5 is an ER stress protein that binds cholesterol and transfers it to the plasma membrane. It additionally binds and regulates 25-hydroxycholesterol (25-HC) levels. However the full function of the StarD5-25-HC axis is unknown. 25-HC ha...
Kinome-wide CRISPR-Cas9 screens revealed EXOSC10 as a positive regulator of TGF-β signaling [0.03%]
基于CRISPR-Cas9的激酶组筛选发现EXOSC10是TGF-β信号通路的正向调节因子
Dingding Wang,Xinhao Zhang,Jianxun Guo et al.
Dingding Wang et al.
The TGF-β signaling pathway is closely associated with human health and disease, and the systematic identification of factors involved in the TGF-β signaling pathway significantly contributes to the understanding and treatment of various ...
An immortalized adipose-derived stem cells line from the PIK3CA-related overgrowth spectrum: Unveiling novel therapeutic targets [0.03%]
PIK3CA相关过度生长谱系的脂肪源性干细胞永生化细胞系：揭示新的治疗靶点
Bin Sun,Hongrui Chen,Wei Gao et al.
Bin Sun et al.
PIK3CA-related overgrowth spectrum (PROS) encompasses several rare conditions that lead to overgrowth of various body parts resulting from activating variants in PIK3CA. The absence of ideal cell models significantly impedes progress in PRO...
Comprehensive characterization and metabolomics to explore the role of hydrocortisone-induced yin deficiency syndrome in mice [0.03%]
综合表型和代谢组学研究探讨氢化可的松致阴虚证的作用及机制
Wenqi Jin,Lan Yang,Yuxin Zhang et al.
Wenqi Jin et al.
Yin deficiency syndrome is a theoretical concept of traditional Chinese medicine (TCM) that claims an imbalance between Yin and Yang serves as a potential etiological factor disrupting physiological homeostasis. Its diagnosis in TCM is hind...
Sophoricoside reduces inflammation in type II collagen-induced arthritis by downregulating NLRP3 signaling [0.03%]
皂苷通过下调NLRP3信号减轻II型胶原诱导的关节炎炎症
Youyang Liu,Yunlu Zhao,Qi Guo et al.
Youyang Liu et al.
Immune responses, especially NLRP3 signaling in macrophages, play critical roles in rheumatoid arthritis (RA), an autoimmune and inflammatory disease. In this study, we aimed to identify novel therapies for RA. We focused on sophoricoside (...
Molecular dynamics studies reveal the structural impacts of LRRK2 R1441C and LRRK2 D1994A mutations in Parkinson's disease [0.03%]
分子动力学研究揭示LRRK2 R1441C和LRRK2 D1994A突变在帕金森病中的结构影响
Ramisha A Rahman,Bushra Zaman,Md Shariful Islam et al.
Ramisha A Rahman et al.
Parkinson's Disease (PD) is a continuingly deteriorating neurological ailment affecting over 8.5 million patients globally as of 2019, and the numbers are expected to keep rising. To aid in identifying therapeutic targets, molecular dynamic...