Methylmalonic acid at the serum level in the elderly contributes to cell growth via mitochondrial dysfunction in colorectal cancer cell spheroids [0.03%]
血清甲基丙二酸水平通过结直肠癌细胞球体中的线粒体功能障碍促进细胞生长
Arowu R Tanaka,Chiho Murakami,Hideya Yamamoto
Arowu R Tanaka
Methylmalonic acid (MMA) is a small molecule produced during the metabolism of propionate and branched-chain amino acids. Recently, it has been reported that the blood concentration of MMA increases with age and promotes lung cancer metasta...
Identification of novel microRNAs: Biomarkers for pathogenesis of hepatocellular carcinoma in mice model [0.03%]
新型微小核糖核酸的鉴定：作为小鼠肝细胞癌发病机制生物标志物的研究
Shivani Priya,Lakhon Kma
Shivani Priya
Hepatocellular carcinoma (HCC) is the most fatal cancer that has affected both male and female populations globally. With poor diagnosis and patient survival rates, it has become a global need for scientists to come to the aid. The main obj...
Electric-field induced sleep promotion and lifespan extension in Gaucher's disease model flies [0.03%]
电场促进格雷夫病模型果蝇的睡眠和延长寿命
Takaki Nedachi,Haruhisa Kawasaki,Eiji Inoue et al.
Takaki Nedachi et al.
Gaucher's disease (GD) is a genetic disease characterized by a mutation in the metabolic enzyme glucocerebrosidase (GBA1), leading to the accumulation of glucosylceramide in tissues. We previously discovered that a minos-inserted mutation i...
Fateme Sadat Feghahati,Soudeh Ghafouri-Fard
Fateme Sadat Feghahati
Vitiligo is a common skin depigmentation condition caused by selective destruction of melanocytes. It is regarded as a polygenic disorder. In addition to protein-coding loci, non-coding regions of the genome contribute to the pathogenesis o...
Screening of biomarkers for diagnosing chronic kidney disease and heart failure with preserved ejection fraction through bioinformatics analysis [0.03%]
基于生物信息学分析的慢性肾脏病和射血分数保留型心力衰竭诊断标志物筛选研究
Can Hou,Jiayi Xu,Min Zhou et al.
Can Hou et al.
Background: Previous research has established that chronic kidney disease (CKD) and heart failure with preserved ejection fraction (HFpEF) often coexist. Although we have a preliminary understanding of the potential corre...
Computational identification of novel natural inhibitors against triple mutant DNA gyrase A in fluoroquinolone-resistant Salmonella Typhimurium [0.03%]
计算识别新型天然抑制剂对抗耐氟喹诺酮类药物的伤寒沙门氏菌三联突变DNA回旋酶A
Sree Haryini,George Priya Doss C
Sree Haryini
The rising resistance to fluoroquinolones in Salmonella Typhimurium poses a significant global health challenge. This computational research addresses the pressing need for new therapeutic drugs by utilizing various computational tools to i...
Elucidating the therapeutic potential of indazole derivative bindarit against K-ras receptor: An in-silico analysis using molecular dynamics exploration [0.03%]
分子动力学探索下结合(bindarit)对K-ras受体治疗潜能的阐述
Parmar Keshri Nandan,Jayanthi Sivaraman
Parmar Keshri Nandan
Ras gene is frequently mutated in cancer. Among different subtypes of Ras gene, K-Ras mutation occurs in nearly 30 % of human cancers. K-Ras mutation, specifically K-Ras (G12D) mutation is prevalent in cancers like lung, colon and pancreati...
ZhongLi Liao,XueFeng Tang,Bin Yang et al.
ZhongLi Liao et al.
Organ fibrosis, considered as a major global health concern, is a pathological condition often occurring after tissue injury in various organs. The pathogenesis of fibrosis involves multiple phases and multiple cell types. Dopamine is invol...
Application of CRISPR/Cas9 technology in the modeling of Gaucher disorder [0.03%]
CRISPR/Cas9技术在Gaucher病建模中的应用
Mehran Reyhani-Ardabili,Mohadeseh Fathi,Soudeh Ghafouri-Fard
Mehran Reyhani-Ardabili
Gaucher disease (GD) is a metabolic disorder caused by mutations in the GBA1, located on 1q22. This gene encodes glucocerebrosidase (glucosylceramidase) enzyme. GD has a wide range of clinical manifestations from a perinatally lethal type t...
Lichao Cao,Ying Ba,Fang Chen et al.
Lichao Cao et al.
Colorectal cancer (CRC) is a common malignant cancer. Epoxide hydrolases (EHs) are involved in the development of cancer by regulating epoxides, but their relationship with CRC is unclear. We used multiple datasets to confirm the expression...