Development of a general anti-viral therapeutic using cholestosome technology to exploit inhibition of intracellular viral production [0.03%]
利用胆甾体技术开发广谱抗病毒药物以抑制细胞内病毒产生
Lawrence Mielnicki,Julie Hughes,Mary Irving et al.
Lawrence Mielnicki et al.
The recent events of the worldwide Covid-19 pandemic showed the need for a general anti-viral therapeutic, independent of the specific characteristics of the virus, that targets intracellular mechanisms of viral production to prevent the ra...
A comprehensive review of molecular hydrogen as a novel nutrition therapy in relieving oxidative stress and diseases: Mechanisms and perspectives [0.03%]
分子氢作为缓解氧化应激和疾病的新型营养疗法的全面综述：机制与前景
Fatmanur Yıldız,Tyler W LeBaron,Duried Alwazeer
Fatmanur Yıldız
Oxidative stress is responsible for the pathogenesis of many diseases, and antioxidants are commonly included in their treatment protocols. Over the past two decades, numerous biomedical reports have revealed the therapeutic benefits of mol...
Oxidative stress-induced NCC activation in the development of nocturnal polyuria in mice: Therapeutic potential of a sustained hydrogen-releasing silicon-based agent [0.03%]
氧化应激诱导的NCC激活在小鼠夜尿症发病机制中的作用及持续释放氢气的硅基制剂的治疗潜力
Yosuke Sekii,Hiroshi Kiuchi,Kentaro Takezawa et al.
Yosuke Sekii et al.
Nocturnal polyuria is a prevalent condition associated with significant deterioration in quality of life and increased risk of mortality. Despite its clinical relevance, the underlying pathogenesis is poorly understood, and existing therapi...
Hepatic HSD17B6 is dispensable for diet-induced fatty liver disease in mice [0.03%]
肝脏HSD17B6在小鼠饮食诱导的脂肪肝病中是可有可无的
Delong Yuan,Nan Bai,Qihan Zhu et al.
Delong Yuan et al.
Metabolic dysfunction-associated fatty liver disease (MAFLD) affects up to a third of the global population, which causes huge both clinical and economic burdens. However, its therapeutic strategy is still limited. Steroid dysregulation pla...
Integrative analysis of RNA-Seq data and machine learning approaches to identify Biomarkers for Rhizoctonia solani resistance in sugar beet [0.03%]
整合RNA-Seq数据和机器学习方法鉴定糖 beet抗Rhizoctonia solani生物标志物的集成分析
Bahman Panahi,Mahdi Hassani,Nahid Hosseinzaeh Gharajeh
Bahman Panahi
Rhizoctonia solani is a significant pathogen that causes crown and root rot in sugar beet (Beta vulgaris), leading to considerable yield losses. To develop resilient cultivars, it is crucial to understand the molecular mechanisms underlying...
Resistance to FLT3 inhibitors involves different molecular mechanisms and reduces new DNA synthesis [0.03%]
FLT3抑制剂的耐药涉及不同的分子机制并减少新的DNA合成
Jingmei Yang,Ran Friedman
Jingmei Yang
Acute myeloid leukaemia (AML) is a hard to treat blood cancer. Mutations in FLT3 are common among the genetic aberrations that characterise the cancer. Patients initially react to FLT3 inhibitors but drug resistance is a hinder to successfu...
Single-cell RNA sequencing provides new insights into the interaction between astrocytes and neurons after spinal cord injury in mice [0.03%]
单细胞RNA测序技术揭示了脊髓损伤后少突胶质前体细胞的异质性及转录组动力学变化
Zhi Tang,Hengyang Lu,Xiao Yang et al.
Zhi Tang et al.
Background: Spinal cord injury (SCI) is a devastating neurological disease in which astrocytes play a central role. Understanding the relationship between different subtypes of astrocytes and neuron subtypes during the pr...
TiShang Zheng,HengQi Wei,CongJian Zhao
TiShang Zheng
Our study focused on specific ChR2 variants, particularly those with the Step function Opsins (SFO) mutation at the D156-C128 gate. These are widely used in optogenetics due to their heightened sensitivity to light and bi-stable prolonged a...
LINC01322 may serve as a potential diagnostic marker for advanced stage tumors in renal cell carcinoma patients eligible for total nephrectomy [0.03%]
LINC01322可作为肾细胞癌根治性全肾切除术患者晚期肿瘤的潜在诊断标志物
Amirhosein Maharati,Negin Taghehchian,Fatemeh Taghavinia et al.
Amirhosein Maharati et al.
Background: Renal cell carcinoma (RCC) is a common urological cancer globally and shows a favorable prognosis in early stages of the tumor progression. Due to the poor prognosis for metastatic RCC patients, it is crucial ...
Human citrate synthase kinetic simulation to fit rapid, direct, and thiol probe coupled kinetic data [0.03%]
人柠檬酸合酶的动力学模拟以适应快速、直接和硫醇探针偶联的动力学数据
Noah Shackelford,Zach Zavodny,Samantha Schindler et al.
Noah Shackelford et al.
Human citrate synthase (hCS) was kinetically characterized through full progress curve kinetic modelling using kinetic simulation, global fitting of the direct AcCoA to CoA transition, and a coupled thiol probe reaction to better determine ...