Resiquimod induces a mixed Th1 and Th2 response via STAT1 and STAT3 signalling in chickens [0.03%]
RESIQUIMOD通过STAT1和STAT3信号转导在鸡体内产生混合的Th1和Th2反应
Deepthi Kappala,Saravanan Ramakrishnan,Patel Nikunjkumar Prakashbhai et al.
Deepthi Kappala et al.
Resiquimod (R-848), a synthetic TLR7 agonist, modulates immune responses, primarily inducing Th1-biased immunity in mammals. In contrast, our previous studies revealed that R-848 stimulates both Th1 and Th2 responses in chickens. The curren...
Effect of epigallocatechin-3-gallate (EGCG) on cognitive functioning and the expression of APP and BDNF in the hippocampus of rats with streptozotocin -induced Alzheimer-like disease [0.03%]
表没食子儿茶素-3- gallate(EGCG）对类阿尔茨海默氏病大鼠认知功能及海马APP和BDNF表达的影响
Farnaz Ghayour Babaei,Ehsan Saburi,Fatemeh Forouzanfar et al.
Farnaz Ghayour Babaei et al.
We aimed to investigate the potential therapeutic effects of the active substance of green tea, epigallocatechin-3-gallate (EGCG), on behavioral phenotypes and markers of neurogenesis in an Alzheimer disease (AD) rat model. The groups inclu...
Joe Varghese,Jithu James Varghese,Molly Jacob
Joe Varghese
Background: Insulin and iron availability stimulate and regulate erythropoiesis, respectively. The effects of hyperinsulinemia and/or iron overload on erythroid differentiation are unclear. ...
Identification of hub genes, non-coding RNAs and pathways in Renal cell carcinoma (RCC): A comprehensive in silico study [0.03%]
肾细胞癌(RCC)枢纽基因、非编码RNA和通路的鉴定：一个全面的干实验研究
Ahmad Golestanifar,Hengameh Khedri,Parisa Noorabadi et al.
Ahmad Golestanifar et al.
Backgrounds: Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults. RCC begins in the renal tubule epithelial cells, essential for blood filtration and urine production. ...
Unveiling ferroptosis genes and inhibitors in diabetic retinopathy through single-cell analysis and docking simulations [0.03%]
通过单细胞分析和对接模拟揭示糖尿病视网膜病变中的铁死亡基因及抑制因子
Md Maqsood Ahamad Khan,Ananya Ganguly,Shubhrajit Barman et al.
Md Maqsood Ahamad Khan et al.
Diabetic retinopathy (DR) is a common microvascular complication of diabetes and a leading cause of vision loss worldwide. Although several mechanisms have been implicated in the pathogenesis of DR, emerging evidence suggests a link between...
Chihiro Suda,Yasunori Takayama,Makoto Tominaga et al.
Chihiro Suda et al.
Propofol, an intravenous anesthetic, has a side effect of causing vascular pain at the injection site. However, no effective method to inhibit this vascular pain has been established. Propofol-induced vascular pain is caused by activation o...
Modified creatine greatly increases the performance of skeletal and smooth muscles [0.03%]
改良版肌酸大大提升了骨骼肌和平滑肌的性能
Anatoly Soloviev,Vadym Kozlovsky,Dmytro Nozdrenko et al.
Anatoly Soloviev et al.
Creatine is a nitrogen-containing carboxylic acid and a main component of phosphocreatine. In recent years, creatine is considered as a component of dietary nutrition, to improve the efficiency of physical activity and increase muscle mass ...
Ganoderma lucidum polysaccharide attenuates retinal ischemia-reperfusion injury by regulating microglial M1/M2 polarization, suppressing neuroinflammation and inhibiting JAK2/STAT3 pathway [0.03%]
灵芝多糖通过调节小胶质细胞M1/M2极化、抑制神经炎症和抑制JAK2/STAT3途径来缓解视网膜缺血再灌注损伤
Guangyu Zhu,Yujie Liu,Shichun Luo et al.
Guangyu Zhu et al.
Retinal ischemia-reperfusion (RIR) injury is implicated in the pathogenesis of numerous retinal degenerative disorders, resulting in visual impairment or even blindness in millions of individuals worldwide. In recent years, targeting the su...
Melatonin ameliorates astrogliosis and microgliosis in a cuprizone demyelinating mouse model [0.03%]
褪黑素改善杯rizone脱髓鞘小鼠模型中的星形胶质细胞激活和小胶质细胞浸润反应
Mehdi Alidadi,Negar Omidi,Mahdad Abdi et al.
Mehdi Alidadi et al.
Background and purpose: Several investigations have reported that melatonin is involved in the amelioration of the inflammatory process, improvement of myelin function, and regeneration in the central nervous system (CNS)...
Renoprotective mechanisms of celastrol in high glucose-mediated HK-2 cell injury through inhibition of the PI3K/Akt/NF-κB signalling pathway [0.03%]
雷公藤红素通过抑制PI3K/AKT/NF-κB信号途径诱导高糖介导的HK-2细胞损伤的肾保护机制研究
Xiaojuan Wang,Mohamad Hafizi Abu Bakar,Mohd Asyraf Kassim et al.
Xiaojuan Wang et al.
Hyperglycemia-induced inflammation and fibrosis in renal tubular epithelial cells are critical factors driving the progression of diabetic nephropathy (DN). Celastrol, a bioactive compound derived from Tripterygium wilfordii Hook.F, is reco...