Forensic validation and population genetic evaluation of an MPS-based integrated microhaplotype and Y-SNP/STR (MY) system [0.03%]
基于MPS的微等位基因和Y-SNP/STR(MY)体系的法医学验证及群体遗传学研究
Haoliang Fan,Qiqian Xie,Fenglong Yang et al.
Haoliang Fan et al.
Microhaplotypes (MHs) and Y-chromosomal single nucleotide polymorphisms (Y-SNPs) and short tandem repeats (Y-STRs) are highly informative genetic markers that complement the limitations of conventional autosomal forensic markers. We evaluat...
ARHGAP12 loss promotes tumor budding and lymphatic metastasis in gastric cancer [0.03%]
ARHGAP12缺失促进胃癌的肿瘤芽生和淋巴转移
Yong Ji,Xiaofeng Xu,Shihan Chen et al.
Yong Ji et al.
Background: Identifying the molecular drivers of metastasis and tumor budding (Tb) is essential for improving patient outcomes. This study aimed to characterize the expression pattern and functional contribution of ARHGAP...
Comparative bioaccumulation and biotransformation of selenate, selenite, and selenomethionine in Cordyceps militaris [0.03%]
镉积累和三种硒化合物在虫草中的生物累积及代谢研究
Yong Zhang,Ting Hu,Bingjie Zhao et al.
Yong Zhang et al.
Selenium (Se) is an essential trace element for humans. Cordyceps militaris is an edible mushroom with nutritional value. To develop a selenium biofortification strategy for C. militaris, the absorption and transformation of selenium from s...
RL-QN15 accelerates vaginal mucosal repair by regulating inflammatory, autophagic, and apoptotic responses [0.03%]
RL-QN15通过调节炎症、自噬和凋亡反应加速阴道粘膜修复
Yue Jia,Yuying Pang,Ying Liu et al.
Yue Jia et al.
Background: Vaginal mucosal injury, caused by infection, trauma, or estrogen deficiency, poses a significant clinical challenge with limited effective therapies. Autophagy and apoptosis are critical regulators of mucosal ...
Renoprotective effects of gut NHE3 inhibitor tenapanor in a rat model of unilateral renal ischemia-reperfusion injury with contralateral nephrectomy [0.03%]
一种肠道NHE3抑制剂Tenapanor的肾保护作用：结合肾脏切除的单侧肾脏缺血再灌注损伤大鼠模型中的作用效应研究
Mitsuhiro Yamaguchi,Yukihiro Hitaka,Shunya Tsuji et al.
Mitsuhiro Yamaguchi et al.
Kidney ischemia-reperfusion (I/R) injury is an unavoidable complication of kidney transplantation that contributes to acute kidney injury (AKI), chronic kidney disease (CKD), and limited long-term graft survival. Elevated serum phosphate ha...
Establishment and characterization of a mouse model of cisplatin-induced olfactory aversion [0.03%]
顺铂诱导的小鼠嗅觉厌恶模型的建立及表征
Haruto Nakano,Yoshihisa Koyama,Koh Shinoda et al.
Haruto Nakano et al.
Chemotherapy-induced sensory alterations, including changes in taste and smell, have been reported as adverse effects of anticancer treatments. However, olfactory aversion has received little attention, and its underlying mechanisms remain ...
Viral dsRNA drives hyperinflammatory but blunted antiviral responses with enhanced PD-L1 induction in a COPD-like airway epithelial model [0.03%]
小气道上皮细胞中病毒dsRNA诱导过度炎症但抗病毒反应减弱并增强PD-L1表达
Megumi Hayashi,Keiko Ueno-Shuto,Ryunosuke Nakashima et al.
Megumi Hayashi et al.
Programmed death-ligand 1 (PD-L1) suppresses T-cell activation during antiviral immune responses, and its expression is increased in airway epithelial cells after viral infection. Because chronic obstructive pulmonary disease (COPD) is char...
Intercellular transfer of LncRNA NEAT1 drives post-infarction inflammation by blocking the macrophage IRG1-itaconate metabolic axis [0.03%]
细胞间转移的长链非编码RNA NEAT1通过抑制巨噬细胞IRG1-丁二酸代谢轴驱动心梗后炎症反应
Jiacheng Ge,Diankui Ge
Jiacheng Ge
Post-infarction inflammation and adverse remodeling remain major therapeutic challenges in ischemic heart disease. However, how specific intercellular communication drives macrophage metabolic maladaptation during this process remains uncle...
TRP matters: a pilot study on expression of mRNA in the parotid glands and their benign tumors [0.03%]
TRP有无关系：一项有关腮腺及其良性肿瘤中mRNA表达的试验研究
Lukas Louis,Gentiana Wenzel,Alessandro Bozzato et al.
Lukas Louis et al.
Purpose: The transient receptor potential (TRP) channels are a group of nonselective cation channels, which play critical roles in a variety of physiological processes and are also involved in the development of various c...
Clinical pathological changes in prostate cancer patients after hormonal therapy: A single-center pilot study [0.03%]
激素治疗后前列腺癌患者临床病理变化的单中心队列研究
Raghda W Magar,Mona Refaat Sadeq,Sawsan El-Halawani et al.
Raghda W Magar et al.
Background: Prostate cancer (PCa) remains a leading malignancy with variable prognosis, and while PSA is widely used for disease monitoring, it frequently lacks sufficient specificity. This study investigated plasma coagu...