High-pressure microjet system enhances epidermal delivery of hydrophilic actives [0.03%]
高压微射流系统可增强亲水性功效成分的经皮传输
Yoanna Gouchtchina,Wilmer L Sibbitt Jr,Pawel Kubik et al.
Yoanna Gouchtchina et al.
Background: The stratum corneum is the principal barrier limiting topical delivery of hydrophilic molecules. We hypothesized that high-pressure microjet (HPMJ) systems would enhance epidermal deposition without breaching ...
GADD45A may be a potential biomarker associated with endoplasmic reticulum stress in focal segmental glomerulosclerosis [0.03%]
GADD45A可能是与局灶节段性肾小球硬化的内质网应激相关的一个潜在生物标志物
Hongyu Wang,Jun Zou,Hongbin Li et al.
Hongyu Wang et al.
Objective: This study aimed to identify and validate potential endoplasmic reticulum stress-related biomarkers of focal segmental glomerulosclerosis(FSGS). ...
Impact of carbon and nitrogen source variation on B-vitamin accumulation in Yarrowia lipolytica: Toward microbial fortification of food ingredients [0.03%]
碳氮源变化对解脂耶氏酵母B族维生素积累的影响：用于食品成分的微生物强化道路上的一项研究
Panwana Khunnonkwao,Sitanan Thitiprasert,Atsushi Minamino et al.
Panwana Khunnonkwao et al.
Yarrowia lipolytica is a food-compatible yeast with strong potential for sustainable B-vitamin enrichment of functional food ingredients. This study evaluated the effects of glucose, xylose, mixed, and lignocellulosic sugars, as well as div...
Beyond the structure-function paradigm: A comprehensive review of intrinsically disordered proteins [0.03%]
超越结构功能范式：内在无序蛋白综述
Sami N Al Harake,Said Btadini,Abrar H Qadri et al.
Sami N Al Harake et al.
Intrinsically disordered proteins (IDPs) and regions (IDRs) challenge the classical structure-function paradigm by fulfilling essential biological roles in the absence of a stable three-dimensional fold. Rather than occupying fixed conforma...
A hybrid machine learning framework with two-step feature selection for identifying key biomarkers and drug targets in monkeypox [0.03%]
一种两步特征选择的混合机器学习框架用于识别猴痘的关键生物标志物和药物靶点
Md Faruk Hosen,S M Hasan Mahmud,Sakib Sarker et al.
Md Faruk Hosen et al.
Monkeypox (Mpox) is a viral disease that has garnered global attention due to its human-to-human transmissibility and cross-species transmission. Recent outbreaks in both endemic and non-endemic regions highlight the urgent need to elucidat...
Circadian rhythm lncRNA NRON is dysregulated in autism spectrum disorder: an observational study [0.03%]
自闭症光谱障碍中昼夜节律长链非编码RNA NRON 的失调：一项观察性研究
Asal Ziaei,Zeinab Shirvani-Farsani,Soudeh Ghafouri-Fard
Asal Ziaei
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder. It is marked by difficulties in social communication and the presence of repetitive behaviors. Research has found that disruptions in the body's circadian rhythm and d...
Investigation of Epstein-Barr virus or human cytomegalovirus in pediatric gliomas: A retrospective single-center study from Tunisia [0.03%]
突尼斯儿童胶质瘤中EB病毒或人类巨细胞病毒的检测：一项回顾性的单中心研究
Nabiha Missaoui,Ahlem Bdioui,Zaineb Lajmi et al.
Nabiha Missaoui et al.
The involvement of infectious agents in glioma pathogenesis remains controversial. While adult gliomas have been extensively studied, the potential contribution of viral infections to pediatric gliomagenesis is poorly understood. This study...
Bioactive compounds from Ficus hirta Vahl extract: Molecular mechanisms underlying their anti-inflammatory and antibacterial activities [0.03%]
Ficus hirta凝集素通过TLR4和RhoA/ROCK信号通路发挥抗炎活性及其抑菌作用研究
Yao Dong,Yitong Li,Hengxiu Wang et al.
Yao Dong et al.
Ficus hirta Vahl (F. hirta) is a traditional medicinal plant used for over 300 years in Chinese ethnic medical systems, including the Yao, Zhuang, and Dai. To provide a rigorous and balanced synthesis, this review conducted a systematic lit...
Restoration of oxidative stress by HNF4α deletion in VWA8-null hepatocytes [0.03%]
VWA8缺失的小鼠肝细胞中HNF4α删除恢复氧化应激反应
Moulun Luo,Wuqiong Ma,Rocio Zapata-Bustos et al.
Moulun Luo et al.
VWA8 is a mitochondrial protein expressed at high levels in mitochondria-enriched organs such as the liver, kidney, and heart. Deletion of VWA8 (VWA8-KO) in AML12 mouse hepatocytes leads to oxidative stress characterized by elevated product...
Intranasal administration of Aloe-derived nanovesicles attenuates early radiation-induced lung injury [0.03%]
纳米药用囊泡通过鼻腔给药减轻放射早期损伤的效果研究
Liangliang Zhang,Hua Wang,Yue Shen et al.
Liangliang Zhang et al.
Background: Radiation-induced lung injury (RILI) is a common complication of thoracic radiotherapy and typically progresses from acute radiation pneumonitis to late-stage pulmonary fibrosis. This study investigated whethe...