Potential role of circ_WHSC1 and miR-145-5p in breast cancer promotion [0.03%]
circ_WHSC1和miR-145-5p在乳腺癌发生中的潜在作用
Maryam Abtin,Asghar Hosseinzadeh,Nahid Nafisi et al.
Maryam Abtin et al.
Purpose: This study aims to investigate the potential interplay between circ_WHSC1 and miR-145-5p in breast cancer pathogenesis using in silico tools, assess their clinical relevance, and evaluate the diagnostic utility o...
Enhanced anticancer activity of nanoemulsified cardamom extract via modulation of apoptosis- and lncRNA-associated pathways in colorectal cancer cells [0.03%]
通过调节凋亡和长链非编码RNA相关途径增强纳米乳化肉豆蔻提取物在结直肠癌细胞中的抗癌活性
Tahoora Soltani,Mohammad Karimian,Hamidreza Vaziri et al.
Tahoora Soltani et al.
Colorectal cancer is a common, deadly disease, highlighting the need for safe and effective treatments. This study compared the anticancer effects of crude and nanoemulsified Elettaria cardamomum (cardamom) extract on HCT-116 colorectal can...
Functional characterization of the bovine sour taste receptor Otopetrin 1 (OTOP1) in response to dietary and ruminal acids [0.03%]
反刍动物瘤胃酸环境对牛酸味受体Otopetrin 1（OTOP1）功能的影响及机制研究
Fuminori Kawabata,Yuko Kawabata
Fuminori Kawabata
Cattle frequently consume acidic feeds such as silage and are continuously exposed to acidic substances originating from ruminal fermentation during rumination. These acids are presumed to be detected via sour taste receptors expressed in t...
Eight-week dietary methionine restriction does not impair resistance exercise-induced mTORC1 signalling activation in rats [0.03%]
八周的甲硫氨酸限制饮食不会损害抵抗运动引起的雷帕霉素复合物1信号激活率
Naoki Fukao,Mito Watanabe,Ryo Takagi et al.
Naoki Fukao et al.
Essential amino acids (EAA) and resistance exercise (RE) are well-known approaches to activate muscle protein synthesis. Methionine is an EAA that stimulates mechanistic/mammalian target of rapamycin complex 1 (mTORC1) signalling. It is bel...
Maria Rita Assenza,Federica Barbagallo,Fabiola Moretti
Maria Rita Assenza
Quiescence is a reversible, tightly regulated state in which cells exit the cell cycle while retaining the potential to re-enter proliferation upon an appropriate stimulus. In solid tumors, quiescent cancer cells are thought to contribute t...
Bioanalytical methods for quantification of Bevacizumab in human serum: ELISA versus MSD [0.03%]
人血清中贝伐单抗定量的生化分析方法：ELISA与MSD比较
Vikas Chandnani,Sanjay Tiwari,Manoj Bob et al.
Vikas Chandnani et al.
Bevacizumab (BVZ) is an anti-vascular Endothelial Growth Factor-A monoclonal antibody (mAb) widely used in oncology and ophthalmology indications globally. Accurate quantification of mAbs in biological fluids is an essential prerequisite fo...
In silico exploration of the genomic repertoire of Iranian aquatic bacteria: Prophage carriage, bioactive compound potential, CRISPR-Cas immunity, and integrated defensive-metabolic islands [0.03%]
伊朗水产细菌基因组目录的无机探索：前噬菌体携带，生物活性化合物潜力，CRISPR-Cas免疫和综合防御-代谢岛
Mohammadreza Rahimian,Mohammad Aghazadeh-Soltan-Ahmadi,Bahman Panahi
Mohammadreza Rahimian
The unique and underexplored aquatic ecosystems of Iran represent a significant reservoir of microbial diversity. This study presents the first comprehensive genomic survey of 38 native Iranian bacterial strains from hypersaline lakes and w...
NOHA as a key biomarker to link NOS2 activity to immune checkpoint and cytokine signaling in ER-negative breast cancer [0.03%]
NOHA是连接ER阴性乳腺癌中NOS2活性、免疫检查点及细胞因子信号的关键生物标志物
Olivia Chase,Emmeline Graham,Mack Buczek et al.
Olivia Chase et al.
Background: Estrogen receptor-negative (ER-) breast cancer remains clinically challenging due to its aggressive behavior, lack of targeted therapies, and limited biomarker tools for diagnosis and disease monitoring. While...
Chidamide and Anlotinib act synergistically in Jurkat cells by inhibiting the Hippo signaling pathway [0.03%]
柴塞米联合安罗替尼通过抑制Hippo信号通路在Jurkat细胞中发挥协同作用
Tao Ma,Yuan Yu,Shuting Yang et al.
Tao Ma et al.
Background: T-cell Acute Lymphoblastic Leukemia (T-ALL) is an aggressive hematologic malignancy characterized by drug resistance, relapse and poor prognosis. Chidamide, a histone deacetylase inhibitor, has shown epigeneti...
RNA-sequencing based gene variants observed in patients with hyperlipidemia and premature coronary heart disease: A preliminary study [0.03%]
高脂血症合并早发冠心病患者基因变异的RNA测序初步研究
Wilanee Dechkhajorn,Kriengchai Prasongsukarn,Surachet Benjathummarak et al.
Wilanee Dechkhajorn et al.
Familial hypercholesterolemia (FH) is a genetic disorder characterized by markedly elevated low-density lipoprotein (LDL) cholesterol levels, which primarily progresses to premature or familial coronary heart disease (FH-CHD). This cross-se...