Deciphering gain-of-function from loss-of-function variants with AlphaMissense: A case study with the mechanosensitive PIEZO1 ion channel protein [0.03%]
AlphaMissense区分致病性阳性和阴性突变：以机械敏感离子通道蛋白PIEZO1为例
Joshua Pillai,Adhvaith Sridhar,Kijung Sung et al.
Joshua Pillai et al.
Pathogenic missense mutations are commonly found in protein-coding regions of DNA, and often alter protein function. In the past decade, enormous experimental efforts have been undertaken through the development of functional assays, mutage...
IGSF9 promotes immunotherapy resistance in colon cancer by orchestrating an immunosuppressive tumor microenvironment and enables combinatorial targeting strategies [0.03%]
免疫检查点分子IGSF9通过调控免疫抑制性肿瘤微环境促进结直肠癌免疫治疗抵抗并诱导联合用药增敏作用
Kangfu Dai,Xingxing Yu,Shicheng Zhou et al.
Kangfu Dai et al.
Colon cancer (CC), a significant global health burden with high incidence and mortality, is often accompanied by an immunosuppressive tumor microenvironment (TME) that limits the efficacy of immunotherapy. Immunoglobulin superfamily member ...
The crosstalk between blood-brain barrier and neural cells: bidirectional regulation of brain function and pathology [0.03%]
血脑屏障与神经细胞的相互作用：双向调节大脑功能和病理损伤
Manling Ju,Haozhou Shen,Xiaobao Zhang et al.
Manling Ju et al.
The blood-brain barrier (BBB) serves as a crucial interface between the circulatory system and the central nervous system (CNS), playing a fundamental role in preserving normal brain function and homeostasis.The BBB closely interacts with v...
Protective effects of 3-(4-hydroxy-3-methoxyphenyl) propionic acid against dexamethasone-induced muscle atrophy: modulation of associated genes and oxidative stress in female mice [0.03%]
3-(4-羟基-3-甲氧基苯基）丙酸对DEX诱导的雌鼠肌肉萎缩保护作用：与相关基因和氧化应激的关系研究
Anayt Ulla,Honomi Ogura,Md Mizanur Rahman et al.
Anayt Ulla et al.
Muscle atrophy is a growing concern, particularly in older adults and people with sedentary lifestyles. Because treatment options are limited, extensive research is crucial to discover novel therapeutic agents. Thus, we investigated the eff...
Global distribution and evolution of nine major non-polio enteroviruses revealed by genomic data mining [0.03%]
基于基因组数据挖掘揭示的九种主要非脊髓灰质炎肠道病毒的全球分布和进化
Han Mo,Hui Li,Jiadong Wu et al.
Han Mo et al.
Objectives: This study aimed to elucidate the global epidemic trends and evolutionary characteristics of nine major non-polio enterovirus serotypes (CVA2, CVA4, CVA6, CVA10, CVA16, CVB3, CVB5, EV-A71, and EV-D68) through ...
Evaluation of the antioxidant and anti-inflammatory efficacy of fermented Polygonatum sibiricum using zebrafish model [0.03%]
利用斑马鱼模型评估景天SSF的抗氧化和抗炎功效
Wenjuan Cao,Chongxi Yang,Yilin Feng et al.
Wenjuan Cao et al.
Background: Fermentation may enhance the skincare potential of the traditional Chinese medicine Polygonatum sibiricum (PS). This study aimed to evaluate the anti-oxidant and anti-inflammatory efficacy of fermented Polygon...
Noncoding RNAs and the phytochemical economy: Molecular regulators of secondary metabolism in medicinal plants [0.03%]
非编码RNA与植物次生代谢经济：药用植物次级代谢的分子调节因子
Okechukwu Paul-Chima Ugwu,Melvin Nnaaemeka Ugwu,Hope Onohuean et al.
Okechukwu Paul-Chima Ugwu et al.
Background: Medicinal plants produce specialised (secondary) metabolites including alkaloids, terpenoids, flavonoids and phenolics that underpin pharmaceuticals, nutraceuticals and traditional therapeutics. Although enzym...
Probiotic properties and functional potential of high-GABA Lactiplantibacillus plantarum ZG308 from Sichuan sun-dried vinegar grains (Cupei): in vitro and genomic analysis [0.03%]
四川醋胚（曲皮）中高GABA乳植杆菌ZG308的益生菌性质和功能潜力：体外及基因组分析
Mengxi Cao,Weizhou Li,Xiaoqin He et al.
Mengxi Cao et al.
Research on γ-aminobutyric acid (GABA) producing probiotics has garnered increasing attention, especially the search for high-yield strains. This study aimed to screen high-GABA-producing lactic acid bacteria (LAB) with functional probioti...
Exploring the bioactive potential of bovine pericardium membrane combined with hyaluronic Acid: characterization and cellular viability analyses [0.03%]
结合透明质酸的牛心包膜生物活性的研究：特性及细胞活力分析
Dwi Wahyu Indrawati,Ernie Maduratna Setiawatie,Retno Pudji Rahayu et al.
Dwi Wahyu Indrawati et al.
This study explores the bioactive potential of bovine pericardium membranes combined with hyaluronic acid (HA, 120 kDa) at concentrations of .5%, 1.0%, and 2.0% through physicochemical characterization and fibroblast cell viability analysis...
Functional polymorphisms in pigmentation-related genes MC1R and DCT display population-specific association with wet age-related macular degeneration [0.03%]
与年龄相关性黄斑变性疾病发病相关的色素生成基因MC1R和DCT的功能多态性不同的种族人群有着不同的关联性
Mika Reinisalo,Seppo Helisalmi,Ali Koskela et al.
Mika Reinisalo et al.
Age-related macular degeneration (AMD) is among the leading causes of vision loss. Factors increasing the risk of AMD include aging, smoking, cardiovascular diseases and heritability. Although melanin pigment is known to protect retinal hom...