Deciphering the molecular crosstalk between type 2 diabetes and pancreatic cancer through cross-disease co-expression network analysis [0.03%]
通过跨疾病共表达网络分析解读2型糖尿病与胰腺癌之间的分子交叉作用关系
Fariba Dehghanian,Sheyda Khalilian,Zaynab Mousavian et al.
Fariba Dehghanian et al.
Multiple complex mechanisms link type 2 diabetes mellitus (T2DM) with the pathogenesis, development, and progression of pancreatic cancer (PC). This study aims to elucidate these complex relationships using cross-disease co-expression analy...
Targeted molecular docking-guided insights into the antioxidant reparative mechanisms of Brassica rapa L. extract after H2O2-induced neurotoxicity in PC-12 cells: Integration of LC-MS metabolomics and transcriptomic responses [0.03%]
基于分子对接的芸苔抗氧化修复机制研究：整合代谢组学与转录组学响应集成液相色谱-串联质谱技术诱导的神经毒性PC-12细胞中的布拉氏芸苔提取物
Wenyuan Wan,Yuntao Zhang,Xiaotong Yang et al.
Wenyuan Wan et al.
This study investigated the reparative effects of Brassica rapa L. ethanolic extract (BREE) on H2O2-induced oxidative injury in PC-12 cells. Brassica rapa L., a cruciferous plant rich in bioactive flavonoids, exhibits potent antioxidant and...
Integrative phytochemical profiling and systems pharmacology identify ERBB2-MAPK1-AKT1 signaling as a molecular basis for the anti-vertigo effects of Ziyin Zhixuan Decoction [0.03%]
整合植物化学谱分析和系统药理学鉴定出ERBB2-MAPK1-AKT1信号传导是紫茵智眩方抗眩晕效应的分子基础
Jing Wang,Hua Guo,Jingru Liu et al.
Jing Wang et al.
Deciphering the polypharmacological mechanisms of chemically complex therapeutics remains a central challenge in systems biochemistry. Here, we developed an integrated computational-experimental framework to elucidate the molecular basis un...
Sarco/endoplasmatic reticulum calcium ATPase activity in healthy muscle and Brody disease [0.03%]
正常骨骼肌和Brody病骨骼肌中 sarcopenic/endoaplasmatic reticulum钙依赖性ATP酶的活性
J P Molenaar,M M Snoeck,S Treves et al.
J P Molenaar et al.
The sarco-/endoplasmatic reticulum calcium ATPase (SERCA) is a calcium transporter that plays a key role in the excitation-contraction-relaxation cycle by enabling muscle relaxation. Pathogenic variants in the SERCA-encoding ATP2A1 gene cau...
Isolation, biochemical characterization and enzymatic profiling of Plant Growth-Promoting Rhizobacteria associated with chilli (Capsicum annuum L.) [0.03%]
与辣椒(Capsicum annuum L.)根系相关的优势促生细菌的分离、生物化学特征及酶活性分析
Pushpa Gehlot,Jyoti Yadav,Priya Soni et al.
Pushpa Gehlot et al.
The rhizosphere is a critical hotspot of plant-microbe interactions, where Plant Growth-Promoting Rhizobacteria (PGPR) play key roles in nutrient mobilization, growth promotion and stress tolerance. This study aimed to isolate and character...
A different MAPK, ERK5 plays a critical role in cell specification and differentiation [0.03%]
一个新的MAPK成员ERK5在细胞分化和决定中起关键作用
Jianhua Li,Xiaoli Hou,Xiao Li et al.
Jianhua Li et al.
Extracellular signal-regulated kinase 5 (ERK5), a unique member of the mitogen-activated protein kinase (MAPK) family, plays a critical role in cell fate determination due to its distinct structure. This review aims to systematically summar...
Platelet-platelet aggregates at single-event resolution as parameter in health monitoring [0.03%]
基于单个事件的血小板聚集作为健康监测参数
Sander Bekeschus,Lea Miebach,Broder Poschkamp et al.
Sander Bekeschus et al.
Platelet analysis is crucial to assess in hemostasis, health, and disease. Current diagnostics primarily analyze bulk platelets, limiting the assessment of subtle, single-aggregate changes. We utilize Plateaggrate, a novel neuronal network-...
Non-linear age-related change in human Interleukin-11 and the receptor subunit alpha DNA methylation [0.03%]
人类白介素11和受体亚基αDNA甲基化的非线性年龄相关变化
Akiyoshi Shimura,Varun B Dwaraka,Kyosuke Yamanishi et al.
Akiyoshi Shimura et al.
Introduction: Interleukin-11 (IL-11) is a cytokine involved in inflammatory processes and a previous study showed that blocking or knocking down IL11 in mice prolongs a healthy lifespan. This study investigates DNA methyl...
BMAL1 attenuates myocardial infarction-induced fibrosis via suppressing p-SMAD3/SMAD3 in TGF-β1 pathway [0.03%]
抑制TGF-β1通路中p-SMAD3/SMAD3表达减轻心肌梗死后心室重构及纤维化的发展
Dewen Zhang,Hao Wang,Ziyi Gu et al.
Dewen Zhang et al.
Cardiac function is markedly impaired as a result of myocardial fibrosis, a major pathological consequence that develops after myocardial infarction (MI). While BMAL1 (Brain and Muscle ARNT-like protein 1), a core circadian rhythm regulator...
Identification and experimental validation of biomarkers associated with integrated stress response in sepsis [0.03%]
用于脓毒症的整合应激反应相关生物标志物的鉴定及实验验证
You Zhou,You Wu,Yuan Zhu et al.
You Zhou et al.
Background: Strategies that specifically target the integrated stress response (ISR) as a therapeutic approach in sepsis remain largely unexplored. This study aimed to identify and validate ISR-related biomarkers in sepsi...