Laura Tünnermann,Justine Colou,Torgny Näsholm et al.
Laura Tünnermann et al.
Saccharomyces cerevisiae is a widely used model organism for the molecular analysis of genes and proteins. Several methods have been developed to study protein function and activity through heterologous gene expression, including yeast two-...
Network-based toxicological analysis of core targets and pathways of bisphenol A-driven hepatocellular carcinoma [0.03%]
网络毒理学方法分析双酚A驱动的肝细胞癌核心靶点及作用通路
Yanan Zhang,Yang Wu,Chujiang Wu et al.
Yanan Zhang et al.
Background: Bisphenol A (BPA), an industrial compound widely used in plastics and food packaging, has been implicated in the development of various diseases. This study aims to elucidate the molecular toxicity mechanisms ...
Whole exome sequencing identifies somatically mutated genes in bladder cancer: A pilot study from Bangladesh [0.03%]
外显子组测序识别膀胱癌中体细胞突变基因：一项来自孟加拉国的试点研究
Hasib Uddin Ahmed,Md Raiyan Hosen,Munshi Akid Mostofa et al.
Hasib Uddin Ahmed et al.
Bladder cancer, ranking as the tenth most common cancer globally, lacks genomic characterization in Bangladeshi patients. This study is an exploratory analysis of the genomic landscape of bladder cancer in this population by conducting whol...
Clinicopathological significance of microRNA-9 and microRNA-34 methylation in non-small cell lung cancer [0.03%]
非小细胞肺癌中微RNA-9和微RNA-34甲基化的临床病理意义
Nabiha Missaoui,Hajer Hamchi,Oussama Belkacem et al.
Nabiha Missaoui et al.
DNA methylation is a key epigenetic mechanism involved in lung carcinogenesis. MicroRNAs (miRs) regulate gene expression and cellular processes, and their aberrant methylation may contribute to dysregulation in non-small cell lung cancer (N...
Exercise rejuvenates bone marrow mesenchymal stem cells associated with the inhibition of inflammatory factors and senescence-related factors [0.03%]
运动通过抑制炎症和衰老相关因素活化骨髓间充质干细胞
Xiu-Juan Dong,Qi Zhao,Wei-Min Zhang et al.
Xiu-Juan Dong et al.
Objective: To investigate the effects of exercise on bone marrow stem cells (BMSCs) and determine underlying molecular network mechanisms through bioinformatics analysis combined experimental validation. ...
Désirée Schibler,Anna Landsmann,Petra Wolint et al.
Désirée Schibler et al.
Objective: Magnetic nanoparticles (MNPs) show promise in many biomedical applications, including magnetic resonance imaging (MRI). Iron carbide compounds are good theragnostic contrast agents. Being nanosized might enable...
In silico docking and in vivo assessment of Mondia whitei fruit extract in attenuating CdCl2-Induced neurodegeneration in rat [0.03%]
模拟对接和体内评估蒙迪亚白色果提取物在减轻大鼠CdCl2诱导的神经退行性病变中的作用
Scholastica O Anadozie,Olusola B Adewale,Oluwole B Akawa et al.
Scholastica O Anadozie et al.
Cadmium is a toxic heavy metal found in the atmosphere. Its frequent exposure can lead to neurodegeneration. Medicinal plants are scavengers of free radicals that could result from exposure to heavy metals. In this study, the neuroprotectiv...
Quantification of glycosaminoglycans in dried blood spots, and evaluation of its usefulness as a secondary newborn screening test for mucopolysaccharidoses [0.03%]
干血点糖胺聚糖定量检测及评估其作为黏多糖贮积症新生儿筛查试验的可行性研究
Wataru Oboshi,Asami Hirakiyama,Masahiro Miura et al.
Wataru Oboshi et al.
Mucopolysaccharidoses (MPS) are a group of lysosomal disorders characterized by pathological accumulation of glycosaminoglycans (GAGs). Enzyme-based newborn screening (NBS) for MPS often yields high false-positive rates because of carriers ...
ATM inhibition restores IFN-γ sensitivity and induces ferroptosis in NSCLC via DNA damage response [0.03%]
ATM抑制恢复了NSCLC的IFN-γ敏感性并通过DNA损伤反应诱导铁死亡
Muhammad Irshad Farooq,Sisca Ucche,Mariho Uozumi et al.
Muhammad Irshad Farooq et al.
Cancer immunotherapy has demonstrated remarkable clinical success across diverse tumor types. Nevertheless, durable responses occur in only a subset of patients, and both primary and acquired resistance remain major challenges. Interferon-...
From mutation to treatment: The dual role of BRCA1 and BRCA2 in gynecological malignancy development and management a systematic review [0.03%]
从突变到治疗：BRCA1和BRCA2在妇科恶性肿瘤发生和发展中的双重作用的系统评价研究
David M Georgy,Hana Nagah Sedeek,Nawal Essam Abaza et al.
David M Georgy et al.
The Breast Cancer gene 1 (BRCA1) and Breast Cancer gene 2 (BRCA2) genes are pivotal human tumor suppressor genes that are essential for preserving genomic stability. Mutations in BRCA1 and BRCA2 prevent homologous recombination, which is re...