Comprehensive analysis of mutational signatures and corresponding driver genes in cervical cancer from Xinjiang [0.03%]
新疆宫颈癌的突变特征及其驱动基因的综合分析
Chaoyang Chen,Wenbo Zhao,Min Guo et al.
Chaoyang Chen et al.
Objective: To investigate the mutational characteristics of cervical cancer in Xinjiang and their relationships with tumor driver genes and affected signaling pathways. ...
Differential metabolic responses to hydrogen peroxide-induced oxidative stress in parotid and submandibular gland acinar cell lines [0.03%]
过氧化氢诱导的腮腺和颌下腺小叶细胞系氧化应激代谢反应差异性响应
Golnaz Golnarnik,Anni I Nieminen,Tine M Søland et al.
Golnaz Golnarnik et al.
This study explored how oxidative stress induced by hydrogen peroxide alters metabolite levels in submandibular and parotid salivary gland acinar cells. We investigated the impact of oxidative stress on the metabolite profiles of two saliva...
Characterization of a novel inherited splice-site variant in MAPK8IP3 expands the genetic and phenotypic spectrum of neurodevelopmental disorders [0.03%]
MAPK8IP3的新发剪接位点变异的表征扩展了神经发育障碍的遗传和临床谱系
Sheng Yi,Qi Yang,Xiong Song et al.
Sheng Yi et al.
Background: The MAPK8IP3 gene encodes JIP3, a kinesin-1 adapter protein crucial for axonal transport and JNK signaling pathway regulation. This gene exhibits extreme intolerance to loss-of-function variants. Heterozygous ...
CuiT is a Cu importer required for metal homeostasis in Salmonella enterica [0.03%]
铜转运蛋白CuiT对副溶血弧菌铜吸收和生长的促进作用及其在毒力岛III中的定位分布研究
Zhenzhen Zhao,Karla F Díaz Rodríguez,Andrea A E Mendez et al.
Zhenzhen Zhao et al.
Copper (Cu) is an essential micronutrient that serves as a cofactor for redox enzymes but becomes toxic when unregulated. In bacteria, while Cu efflux systems are well characterized, mechanisms of Cu import remain poorly understood. Here, w...
Integrated transcriptomic and proteomic validation identifies SLC35D3 as a tumor-selective surface antigen for colorectal and neuroendocrine carcinomas [0.03%]
整合转录组和蛋白质组的验证鉴定SLC35D3为结直肠癌和神经内分泌癌的选择性肿瘤表面抗原
Shunsuke Someya,Tatsuya Inoue,Reimi Kawaida et al.
Shunsuke Someya et al.
Antibody-drug conjugates (ADCs), bispecific T-cell engagers (TCEs), and chimeric antigen receptor (CAR)-T cells require truly tumor-restricted surface antigens to minimize on-target/off-tumor toxicity. To identify such antigens, we interrog...
APLNR reduction in kidney-muscle crosstalk in renal model recovered by exercise and STAT3 inhibition [0.03%]
运动和STAT3抑制可改善肾性模型的肾脏-肌肉通讯障碍(APLN减少)
Gabriel Pereira,Thabata Caroline de Oliveira Santos,Sofía Tomaselli Arioni et al.
Gabriel Pereira et al.
Current evidence show that exercise has beneficial effects on skeletal muscle function in individuals with chronic kidney disease (CKD). The STAT3 signaling pathway and the apelin axis (apelin receptor, APLNR- and ligands, -apelin and/or -e...
Embryonic sheep placenta alleviates muscle-fat wasting symptoms and improves gut microbiome dysbiosis in cachexia mice [0.03%]
胚胎羊胎盘可缓解恶病质小鼠的肌少症和脂肪减少症状并改善肠道微生物群失调
Mengze Sun,Lixue Tu,Zhongkun Zhou et al.
Mengze Sun et al.
Cachexia is a multifactorial wasting syndrome characterized by muscle-fat depletion, accompanied by significant gut microbiome disturbances. Embryonic sheep placenta (ESP), a functional food known to modulate immunity and gut microbiome, re...
Epigenetic regulation by gut microbiota-derived metabolites in celiac disease [0.03%]
肠道微生物群衍生代谢物在乳糜泻中的表观遗传调控作用
Marzieh Khaneshi,Fatemeh Alizadeh,Armin Ghahremanzadeh et al.
Marzieh Khaneshi et al.
Celiac disease (CeD) is a chronic autoimmune disorder triggered by gluten in genetically susceptible individuals carrying HLA-DQ2/DQ8 haplotypes. Although genetic predisposition and gluten exposure are necessary, they are insufficient in th...
Antimicrobial efficacy of carbon nanotube-based nano drug on Escherichia coli and expression of Acr AB gene involved in bacterial drug resistance [0.03%]
碳纳米管载药纳米材料的抗菌功效及药物抗性细菌acrAB基因表达量的影响机制研究
Erfan Rahimi,Hadi Baharifar,Mojgan Sheikhpour
Erfan Rahimi
Background: The most common form of nosocomial infection is urinary tract infection, which is more prevalent among women. E. coli has been known as the main agent involved in urinary tract infections, and Ampicillin (AMP)...
Transforming Duchenne muscular dystrophy therapy: The multifaceted role of extracellular vesicles and exosomes [0.03%]
转化杜氏肌营养不良症疗法：细胞外囊泡和外泌体的多面作用
Fatemeh Farzi,Fatemeh Soltanmohammadi,Seyed Abolghasem Mohammadi et al.
Fatemeh Farzi et al.
Duchenne muscular dystrophy (DMD) remains a devastating X chromosome-linked disorder with restricted curative options. Additionally, the existing treatment approaches, such as growth-modulating agents, anti-inflammatory drugs, antisense oli...