The role of HAI-1 in urothelial bladder cancer: Tissue expression, ectodomain shedding and clinical outcomes [0.03%]
HAI-1在尿路上皮膀胱癌中的作用：组织表达、外域脱落和临床结局
Azad K Saeed,Panagiotis Triantafyllakis,Naheema S Gordon et al.
Azad K Saeed et al.
Hepatocyte growth factor activator inhibitor type-1 (HAI-1) plays pivotal roles in epithelial integrity and tumour biology. Although implicated in various malignancies, its expression profile and prognostic value in bladder cancer (BC) rema...
The unseen impact of subclinical hypothyroidism on lipid profile and cardiovascular risk [0.03%]
亚临床甲状腺功能减退对血脂谱和心血管风险的隐形影响
Muhanad Salah Mawlood
Muhanad Salah Mawlood
Background: Subclinical hypothyroidism (SCH), defined by elevated thyroid-stimulating hormone (TSH) with normal circulating thyroid hormones, is a common endocrine disorder that frequently remains clinically silent. Emerg...
Screening of metabolic-related biomarkers linking intervertebral disc degeneration and type 2 diabetes based on comprehensive bioinformatics analysis and machine learning [0.03%]
基于综合生物信息学分析和机器学习的腰椎间盘退变与2型糖尿病相关代谢标志物的筛选研究
Ba Qiu,Tao Chen,Qi Hong et al.
Ba Qiu et al.
Background: Intervertebral disc degeneration (IVDD) is a prominent etiology of lower back pain. Type 2 diabetes (T2D), the most prevalent metabolic disorder, may expedite IVDD progression through mechanisms involving hype...
Isolation and genetic analysis of an Enterococcus gallinarum strain with high GABA-producing capacity from the murine intestine [0.03%]
一株高产γ-氨基丁酸的肠球菌来源肠道细菌的分离鉴定及遗传分析
Mion Ikegami,Miyu Yamashita,Ren Kadowaki et al.
Mion Ikegami et al.
Some intestinal bacteria possess the glutamate decarboxylase (gad) gene and can produce γ-aminobutyric acid (GABA), a major inhibitory neurotransmitter in mammals, from glutamate. The physiological role of gut-microbiota-derived GABA has a...
Appropriate threshold setting and multiple methods combination may improve reproducibility of gene ontology enrichment analysis [0.03%]
适当的阈值设置和多种方法结合可能提高基因本体富集分析的重复性
Qi Guo,Tian Fu,Na Wang et al.
Qi Guo et al.
Transcriptome analyses are widely used for biological research. Gene ontology (GO) enrichment analysis is often used for effectively analyzing large data matrices. However, various software and methods can be used for performing GO enrichme...
Oroxylin A ameliorates hepatic steatosis and non-alcoholic fatty liver disease through the regulation of CPT1A m6A methylation in hepatocytes [0.03%]
牛黄素A通过调节肝细胞CPT1A mRNA m6A甲基化改善肝脏脂质沉积和非酒精性脂肪肝病
Yihong Ji,Han Gu,Mingyue Wang et al.
Yihong Ji et al.
Non-alcoholic fatty liver disease (NAFLD) is a chronic condition that is frequently observed worldwide and has become a threat to global public health. Excess accumulation of hepatic lipids contributes to NAFLD. Oroxylin A has attracted wid...
ECM (collagen) mediated signaling drives the emergence of androgen independence in prostate cancer cells [0.03%]
基质胶原介导的信号驱动前列腺癌细胞去势抵抗的发生发展
Apoorva Abikar,Prathibha Ranganathan
Apoorva Abikar
Extracellular matrix is a major structural component of the tumor microenvironment. It is a dynamic entity that undergoes continuous deposition, remodeling and degradation to maintain tissue homeostasis. ECM plays crucial roles in providing...
Immune profiling of T cells: A comparative analysis of single-cell TCR sequencing using 10X Genomics and Parse Biosciences platforms [0.03%]
T细胞免疫谱分析：使用10X和Parse平台的单细胞TCR测序的比较研究
Nanna Kristjánsdóttir,Kasper Thorsen,Nicolai J Birkbak et al.
Nanna Kristjánsdóttir et al.
Single-cell RNA sequencing (scRNA-seq) is a powerful tool for characterising the immune landscape. Multiple technologies are available, each with distinct specificities and inherent biases. Here, we focus on two technologies-10X Genomics an...
Multivariate analysis and ADME profiling of Rosmarinus officinalis L. leaf vs. stem extracts: Extraction method-driven bioactivity and pharmacokinetic implications [0.03%]
牻牛儿苗叶片与茎的多变量分析及ADME表征：提取方法驱动的生物活性和药代动力学意义
Fatima-Zahrae Ed-Darraz,Saida Tayibi,Sana Mounaimi et al.
Fatima-Zahrae Ed-Darraz et al.
This study evaluated the bioactive potential of Rosmarinus officinalis L. extracts obtained separately from leaves and stems, comparing maceration (ME), Soxhlet (SE), and ultrasound-assisted extraction (UAE) techniques. Phytochemical profil...
Granzyme B-expressing regulatory B cells share the same origin as conventional blood B cells [0.03%]
表达颗粒酶B的调节性B细胞与常规血液B细胞同源
Steve Genebrier,Nicolas Sailliet,Samuel Bastos Serra Trinca et al.
Steve Genebrier et al.
Regulatory B cells (Bregs) play a pivotal role in various dysimmune conditions. We have previously demonstrated that granzyme B-expressing (GZMB+) B cells are more numerous in patients with graft tolerance following kidney transplantation a...