The FOXM1-SESN2 axis maintains redox homeostasis and protects esophageal squamous carcinoma cells from oxidative stress [0.03%]
FOXM1-SESN2轴维持氧化还原稳态并保护食管鳞癌细胞免受氧化应激损害
Zhisheng Wu,Xiaona Zhang,Mantong Chen et al.
Zhisheng Wu et al.
This study aimed to elucidate the role of ROS-related genes in esophageal squamous cell carcinoma (ESCC) prognosis and the cellular mechanisms involving FOXM1 and SESN2. A prognostic model incorporating six genes (FOXM1, SESN2, APOD, GATM, ...
The role of γ-aminobutyric acid and its receptor in metabolic reprogramming and tumor progression [0.03%]
γ-氨基丁酸及其受体在代谢重编程和肿瘤进展中的作用
Yujie Wang,Junzhao Shao,Ming Wang et al.
Yujie Wang et al.
Neurotransmitters play fundamental regulatory roles within the central nervous system (CNS), where they modulate neuronal signaling and maintain neural network homeostasis. Beyond their classical functions in the CNS, these signaling molecu...
TEMIS: A temperature-controlled microwave irradiation system for enhancing extracellular vesicle secretion [0.03%]
一种用于增强细胞外囊泡释放的温度控制微波照射系统(TEMIS)
Haruki Odaka,Sho Nakazora,Hirofumi Soga et al.
Haruki Odaka et al.
Extracellular vesicles (EVs) secreted by cells and tissues are promising tools for disease biomarkers and regenerative medicine, necessitating the establishment of technologies to efficiently enhance their secretion. Here, we investigated t...
Magnetic fields as biophysical activators of autophagy: A preclinical systematic review [0.03%]
磁场作为自噬的生物物理激活剂：一项系统性回顾研究
Enzo Emanuele,Alejandro Santos-Lozano,Susana López-Ortiz et al.
Enzo Emanuele et al.
While pharmacological inducers of autophagy have been extensively studied, their systemic adverse effects may limit clinical use. Increasing preclinical evidence suggests that magnetic fields (MFs) can represent a non-invasive alternative f...
The influence of rosmarinic acid on male reproductive health: Biological mechanisms and clinical prospects [0.03%]
Morteza Jafarinia,Sepide Goharitaban,Bahia Namavar Jahromi et al.
Morteza Jafarinia et al.
Male infertility is a condition affecting up to 15% of couples worldwide. It is frequently driven by oxidative stress and inflammation that impair spermatogenesis and hormone regulation. Rosmarinic acid (RA) as a naturally occurring polyphe...
Integrating AlphaFold2, RoseTTAFold2, and HADDOCK to refine Protein-Protein Interaction (PPI) candidate selection: A case study with ZWINT [0.03%]
结合AlphaFold2、RoseTTAFold2和HADDOCK精炼蛋白质-蛋白质相互作用(PPI)候选选择：以ZWINT为例的研究
Nora Abdelfattah,Bridget Broncales,Ivana Albert et al.
Nora Abdelfattah et al.
Protein-protein interactions (PPIs) underpin most cellular processes, and disruptions to these interactions can lead to cellular dysfunction and disease. Understanding PPIs is essential for studying disease mechanisms, yet traditional exper...
Dishevelled PDZ domain targeting peptides modulate non-canonical Wnt5a/Ror signaling [0.03%]
紊乱蛋白PDZ结合肽可调节非经典的Wnt5a/Ror信号通路
Andrew C Jubintoro,Ho-Jin Lee,Hsin-Yi Henry Ho et al.
Andrew C Jubintoro et al.
Dishevelled (Dvl) is a highly conserved scaffolding protein that plays a key role in the non-canonical Wnt signaling pathway. However, the exact mechanisms by which Dvl modulates pathway activation are not fully understood. The C-terminus o...
Low cytotoxicity of linoleic acid-derived epoxy-fatty acids in liver and colon cell lines [0.03%]
油酸衍生的环氧化脂肪酸对肝和结肠细胞系低毒性强
Henrik Reuter,Nadja Kampschulte,Kathrin Plitzko et al.
Henrik Reuter et al.
Linoleic acid-derived epoxy-fatty acids (EpOMEs) are found in oxidized plant oils and processed foods. Consumption of oxidized oils may lead to a variety of negative health effects. Due to the assumed chemical reactivity of the epoxy-group,...
LncRNA AFAP1-AS1 mediates therapy-dependent expression of CCL5, CXCL10 and MMP9 in multiple sclerosis [0.03%]
长链非编码RNA(AFAP1-AS1)介导多发性硬化症中CCL5、CXCL10和MMP9的表达依赖性疗法
Lina Nasser Hegazy,Aya Aly Elkhodiry,Mohamed Hamed Rashad et al.
Lina Nasser Hegazy et al.
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system. It is characterized by inflammation, areas of demyelination and axonal loss called plaques, recruitment of lymphocytes and monocytes, and bu...
Effects of electromyostimulation on sarcolipin and Ca2+ signaling in rat skeletal muscles [0.03%]
电肌刺激对大鼠骨骼肌sarcolipin和Ca２⁺信号的影响
Koki Okumura,Junya Takegaki,Kohei Sase et al.
Koki Okumura et al.
Calcium ion (Ca2+) acts as a second messenger involved in various adaptations by activating signaling pathways. The expression of Ca2+ regulators is modified by resistance training. Thus, Ca2+ signaling may be altered during a period of res...