Association between serum lipid-apolipoprotein alterations and soluble syndecan-1 dynamics in sepsis: impact of apolipoprotein E isoforms [0.03%]
血清脂质-载脂蛋白变化与脓毒症中可溶性硫酸乙酰肝素蛋白多糖-1动态变化之间的关系：载脂蛋白E亚型的影响
Riho Shimizu,Shogo Akahane,Harue Suzuki et al.
Riho Shimizu et al.
Background: Dyslipidemia is a common feature of sepsis; however, its relationship with inflammation-related biomarkers remains incompletely understood. This study aimed to examine the associations between soluble syndecan...
Integrated single-cell transcriptomic analysis identifies PF4 + /PPBP + megakaryocyte-like granulocytes associated with immune dysregulation in autoimmune diseases [0.03%]
整合单细胞转录组分析鉴定出PF4+ / PPBP+巨核细胞样颗粒细胞与自身免疫疾病中的免疫失调相关
Shaoqi Chen,Yu Fan,Miaotong Su et al.
Shaoqi Chen et al.
Objectives: Megakaryocytes (MKs) and low-density granulocytes (LDGs) are implicated in immune dysregulation and vascular pathology in autoimmune diseases (ADs), yet their precise subsets and pathological interactions rema...
Mapping of uterine-related neurons in central nervous system of mice by trans-synaptic tracing with pseudorabies virus [0.03%]
伪狂犬病毒跨突触追踪法在小鼠中枢神经系统的子宫相关神经元映射研究
Hehua Wang,Jinqiong Zhan,Qingyue Cao et al.
Hehua Wang et al.
The uterus, a key organ for maintaining reproductive health and fertility, is precisely regulated by central nervous system (CNS). This study employed multimodal neural tracing and c-Fos staining to investigate the multisynaptic pathways co...
SGK1 inhibition exerts atheroprotective effects in vascular endothelial cells [0.03%]
SGK1抑制对血管内皮细胞的抗动脉粥样硬化作用
Hiroyasu Yamamoto,Ayu Hirose,Nanako Takada et al.
Hiroyasu Yamamoto et al.
Mineralocorticoid receptor antagonists (MRA) exert anti-atherosclerotic properties in vivo through their combined effects on various cells and tissues. We previously found a significant interaction between TNFα-induced inflammatory pathway...
Long-read transcriptomic profiling of a glioma cell line following m6A regulator perturbations [0.03%]
扰动m6A调控因子后胶质母细胞瘤细胞系的长读取转录组分析
Hanna Lee,Syeda Maheen Batool,Ana K Escobedo et al.
Hanna Lee et al.
N6-methyladenosine (m6A) is the most prevalent internal mRNA modification and is enriched in the central nervous system (CNS), yet its role in glioma remains incompletely defined. Using long-read direct RNA sequencing, we mapped transcripto...
Chlorogenic acid modulates gut microbiota and metabolites to alleviate intrahepatic cholestasis of pregnancy: Insights from 16S rRNA sequencing and metabolomics [0.03%]
氯ogenic酸通过调节肠道菌群和代谢物来缓解妊娠期肝内胆汁淤积：来自16S rRNA测序和代谢组学的启示
Danli Ma,Yanwen Xu,Ruixia Liang et al.
Danli Ma et al.
Intrahepatic cholestasis of pregnancy (ICP) is a liver disorder marked by impaired bile flow, elevated serum bile acids, and pruritus, posing significant risks to maternal and fetal health. Current treatments, including ursodeoxycholic acid...
Insulin preserves fast-twitch muscle mass during early STZ-induced diabetes in rats [0.03%]
胰岛素在早期 streptozotocin 糖尿病大鼠中可保持快缩肌纤维体积
Yuki Yamasaki,Kazuhiro Nomura,Yuka Matsumoto et al.
Yuki Yamasaki et al.
Purpose: Skeletal muscle atrophy is a critical complication of type 1 diabetes mellitus (T1DM), primarily caused by insulin deficiency. While physical activity is known to improve metabolic health, its effectiveness in pr...
The role of nasal microbiota and type 2 innate lymphoid cells in the pathogenesis of allergic rhinitis [0.03%]
鼻部微生物群和2型固有淋巴样细胞在过敏性鼻炎发病机制中的作用
Chen Wang,Yi-Ming Zhang,Min-Li Zhou et al.
Chen Wang et al.
Allergic rhinitis (AR) is a type 2 inflammation-related disease, potentially associated with innate lymphoid cells (ILC2s), nasal microbiota, and autophagy. Mice were divided into control, AR, AR + IL-33, and AR + antibiotic groups(n = 5). ...
Mechanisms of search for specific sites in DNA by DNA-binding proteins [0.03%]
DNA结合蛋白在DNA上寻找特定位点的机制
Maria V Lukina,Olga S Fedorova,Alexander A Chernonosov et al.
Maria V Lukina et al.
Efficient recognition of specific sites in DNA by repair proteins requires resolution of the fundamental "speed-stability paradox." This paradox arises from the need to scan a vast genome rapidly while maintaining high accuracy in lesion de...
Clinicopathological significance of 5'-3' exoribonuclease 2 expression in small cell lung cancer tissues [0.03%]
小细胞肺癌组织中RNA切除酶2的表达及临床病理意义
Rui Lin,Feng Chen,Wei Zhang et al.
Rui Lin et al.
Small cell lung cancer (SCLC) is an aggressive neuroendocrine malignancy. Overall survival in SCLC patients remains poor, and there is a lack of treatment options after the failure of first-line therapy. 5'-3' exoribonuclease 2 (XRN2) is as...