Transcriptomic and alternative splicing reprogramming by low-dose gamma irradiation in tomato under ToBRFV infection [0.03%]
低剂量γ射线辐照重编程番茄感染ToBRFV后的转录组和可变剪接
Abozar Ghorbani,Mahsa Rostami,Davoud Koolivand
Abozar Ghorbani
Tomato brown rugose fruit virus (ToBRFV) is a rapidly spreading pathogen that threatens global tomato production by overcoming established genetic resistance mechanisms. Conventional seed disinfection strategies often fail to eliminate the ...
Small molecules promote the in vitro expansion and passaging of adult mouse pancreatic islets [0.03%]
小分子促进成年鼠胰岛体外扩增和传代
Lingxian Zhang,Kairui Liu,Xiaoxiao Zhang et al.
Lingxian Zhang et al.
Islet-like organs can provide a new solution for the treatment of diabetes and personalized drug testing. However, because adult pancreatic tissue lacks regenerative capacity, it is still not possible to expand islet clusters from adult mic...
Dynamics of enzyme and metabolic profile of broilers fed black soldier fly (Hermetiailucens) larvae-based diets [0.03%]
饲喂黑兵虫（赫尔梅蒂亚卢切尼亚丝） larva 基础日粮的肉鸡消化道内酶和代谢轮廓动态变化
Opeyemi Adetola Oladejo,Deborah Oluwaferanmi Ibiwoye,Ayodeji Amos Faniyi et al.
Opeyemi Adetola Oladejo et al.
This study investigated the impact of replacing fishmeal with black soldier fly larvae meal (BSFLM) on growth performance, microbial enzyme activity, and metabolic functions in broiler chickens. A total of fifty Arbor Acre Plus chicks were ...
O-GlcNAcylation: A bridge for regulating the function of the "heart-kidney-bone axis" [0.03%]
O-连接-N-乙酰葡萄糖胺(O-GlcNAc)修饰：调控“心-肾-骨轴”功能的桥梁作用
Shuangcui Wang,Maojuan Guo,Bo Yang et al.
Shuangcui Wang et al.
The three major organ systems of heart, kidney and bone are highly correlated in physiology and pathology. They form the "heart-kidney-bone axis" together. The typical clinical manifestations of this axis include the deterioration of heart ...
Targeting TLR4/non-canonical NF-κB pathway by Bushen Bitong recipe enhances BMSCs-based cartilage repair in osteoarthritis [0.03%]
补肾骨肽方通过靶向TLR4非经典NF-κB信号通路促进骨髓间充质干细胞软骨分化修复膝骨关节炎损伤
Wenyuan Xiang,Cheng Xiang,Atikul Islam et al.
Wenyuan Xiang et al.
Bushen Bitong Recipe (BSBT) is a traditional Chinese medicine used clinically for osteoarthritis, while bone marrow mesenchymal stromal cell (BMSCs) therapy is increasingly applied for its immunomodulatory and anti-inflammatory properties. ...
Tanshinone IIA attenuates psoriasis via Nrf2/HO-1 activation: Mechanistic insights from preclinical models [0.03%]
丹参酮IIA通过Nrf2/HO-1激活缓解银屑病：来自临床前模型的机制见解
Xia Xu,Jingyao Liang,Maofang Huang et al.
Xia Xu et al.
Background: Psoriasis is a chronic inflammatory skin disorder driven by oxidative stress and immune dysregulation. Tanshinone IIA, a bioactive compound from Salvia miltiorrhiza, exhibits antioxidant properties, but its ro...
Dysregulated serum levels of human tissue kallikreins, hK7 and hK10, as potential biomarkers of asthma [0.03%]
人组织激肽释放酶hK7和hK10失调的血清水平作为哮喘潜在生物标志物的可能性
Samina Ejaz,Faiz-Ul-Hassan Nasim,Iqra Abdullah et al.
Samina Ejaz et al.
Background: Asthma is a highly prevalent inflammatory disease worldwide with limited diagnostic and therapeutic approaches. Objective: ...
Different strategies to enhance the solubility of acylsucrose transferase PaxASAT1 expression in Escherichia coli [0.03%]
提高大肠杆菌中酰基蔗糖转移酶PaxASAT1表达可溶性的策略研究
Li Han,Xueming Yu,Yibo Ning et al.
Li Han et al.
Heterologous expression of soluble proteins is a crucial method for studying gene function and enzyme structure. Escherichia coli is a widely used host for expressing foreign genes from plants, animals, and microorganisms. PaxASAT1, a membe...
Overexpressed Spindlin1 relocalizes to the nucleoli during fixation [0.03%]
过度表达的Spindlin1在固定过程中重新定位到核仁中
Falk Ike Fischer,Antigona Pervetica,Marie Moeser et al.
Falk Ike Fischer et al.
The histone reader protein Spindlin1 has emerged as a pivotal player in tumorigenesis. Consequently, it became a major focus of research and numerous functions and interactions were proposed. In concert, varying subcellular distributions of...
Akiyo Fukuda,Yutaka Koyama,Yuya Denda et al.
Akiyo Fukuda et al.
Abdominal aortic aneurysm (AAA) is a life-threatening vascular disease, and its underlying mechanisms remain incompletely understood. Vascular smooth muscle cells (SMCs) are the predominant cell type in the aortic wall, and SMC dysfunction ...