Resistive spontaneous breathing exacerbated lipopolysaccharide-induced lung injury in mice [0.03%]
小鼠呼吸末正压能够减轻脂多糖所致的急性肺损伤
Zhigui Cai,Huanhuan Zhang,Xingxing Guo et al.
Zhigui Cai et al.
Background: Spontaneous respiratory mechanical force interacted with the primary lung injury and aggravated the progression of ARDS clinically. But the exact role and involved mechanism of it in the pathogenesis of ARDS a...
MicroRNA-409: Molecular functions and clinical applications in cancer [0.03%]
MicroRNA-409：癌症中的分子功能和临床应用
Yasamin Rajabloo,Hanieh Latifi,Iman Akhlaghipour et al.
Yasamin Rajabloo et al.
Late diagnosis is one of the main reasons for high mortality rates in cancer patients. Therefore, investigating the molecular mechanisms involved in tumor progression can improve the cancer diagnosis in the early stages of the tumor progres...
SH-SY5Y human neuronal cells with mutations of the CDKN2B-AS1 gene are vulnerable under cultured conditions [0.03%]
CDKN2B-AS1基因突变的SH-SY5Y神经元细胞在培养条件下容易受损
Michiko Ohno-Oishi,Zou Meiai,Kota Sato et al.
Michiko Ohno-Oishi et al.
Glaucoma is a common cause of blindness worldwide. Genetic effects are believed to contribute to the onset and progress of glaucoma, but the underlying pathological mechanisms are not fully understood. Here, we set out to introduce mutation...
Utility of pemafibrate in nonalcoholic steatohepatitis model mice induced by a choline-deficient, high-fat diet and dextran sulfate sodium [0.03%]
高脂无胆碱饮食和硫酸葡聚糖钠诱导的非酒精性脂肪肝病模型小鼠中贝西帕布的改善作用研究
Takahiro Ota,Koichi Soga,Fuki Hayakawa et al.
Takahiro Ota et al.
Aim: The purpose of this study was to examine the effect of pemafibrate in a murine model of non-alcoholic steatohepatitis (NASH). Methods: ...
Function and expression of N-acetyltransferases 1 and 2 are altered in lymphocytes in type 2 diabetes and obesity [0.03%]
2型糖尿病和肥胖患者淋巴细胞中乙酰转移酶1和2的功能和表达改变
Víctor Alejandro Paz-Rodríguez,Diana Judith Herrera-Vargas,Eneida Turiján-Espinoza et al.
Víctor Alejandro Paz-Rodríguez et al.
The cytosolic enzymes N-Acetyl Transferases 1 and 2 (NATs) transfer an acetyl group from acetyl-CoA to a xenobiotic substrate. NATs are regulated at the genetic and epigenetic levels by deacetylase enzymes such as sirtuins. The enzymatic ex...
HLF is a promising prognostic, immunological, and therapeutic biomarker in human tumors [0.03%]
HLF是一个有前景的肿瘤预后、免疫学和治疗生物标志物
Mohsen Ahmadi,Amirhossein Mohajeri Khorasani,Firouzeh Morshedzadeh et al.
Mohsen Ahmadi et al.
Despite past research linking HLF mutations to cancer development, no pan-cancer analyses of HLF have been published. As a result, we utilized multiple databases to illustrate the potential roles of HLF in diverse types of cancers. Several ...
Pan-cancer prognosis, immune infiltration, and drug resistance characterization of lung squamous cell carcinoma tumor microenvironment-related genes [0.03%]
泛癌症预后、免疫浸润和药物耐药性特征的肺鳞状细胞癌肿瘤微环境相关基因表征
Xiao Chen,Rui Li,Yun-Hong Yin et al.
Xiao Chen et al.
Background: The tumor microenvironment (TME) plays an important role in cancer development; however, its implications in lung squamous cell carcinoma (LUSC) and pan-cancer have been poorly understood. ...
Revealing gene expression heterogeneity in a clonal population of Tetrahymena thermophila through single-cell RNA sequencing [0.03%]
通过单细胞RNA测序揭示 Tetrahymena thermophila 纯系种群中的基因表达异质性
Hiroki Kojima,Akiko Kashiwagi,Takashi Ikegami
Hiroki Kojima
We performed single-cell RNA sequencing (scRNA-seq) on a population of 5,000 Tetrahymena thermophila, using the 10x Genomics 3' gene expression analysis, to investigate gene expression variability within this clonal population. Initially, w...
Development of a fluorescence-based excipient screening for improved stability and shelf-life of recombinant chitin deacetylase [0.03%]
基于荧光的辅料筛选的发展，以提高重组几丁质脱乙酰酶的稳定性和保质期
Goutam Mohan Pawaskar,Ritu Raval
Goutam Mohan Pawaskar
Chitin deacetylase (CDA) modifies chitin into chitosan by removing acetyl groups, but its inherent instability poses a challenge for successful crystallisation. Despite limited successes in crystallizing CDAs, prior attempts with recombinan...
Hybrid sequence-based analysis reveals the distribution of bacterial species and genes in the oral microbiome at a high resolution [0.03%]
基于序列的混合分析以高分辨率揭示口腔微生物菌群中的细菌种类和基因分布规律
Masaya Yamaguchi,Toshihiro Uchihashi,Shigetada Kawabata
Masaya Yamaguchi
Bacteria in the oral microbiome are poorly identified owing to the lack of established culture methods for them. Thus, this study aimed to use culture-free analysis techniques, including bacterial single-cell genome sequencing, to identify ...