Nuclear envelope morphology change upon repetitive treatment with modified antisense oligonucleotides targeting Hutchinson-Gilford Progeria Syndrome [0.03%]
针对Hutchinson-Gilford早老综合征的修饰反义寡核苷酸重复处理后核包膜形态的变化
Asmaa Abdelrahman,Mette-Marie Wendelboe Nielsen,Mette Halkjær Stage et al.
Asmaa Abdelrahman et al.
We present the influence of treating progeroid fibroblasts with two modified antisense oligonucleotides (ONs) on the nuclear envelope. Two modified ONs were designed to block ribosome binding during translation and spliceosome binding at th...
Chronic kidney disease and NLRP3 inflammasome: Pathogenesis, development and targeted therapeutic strategies [0.03%]
慢性肾脏病与NLRP3炎症小体：病理机制、发展及靶向治疗策略
Gengzhen Huang,Yaodan Zhang,Yingying Zhang et al.
Gengzhen Huang et al.
Chronic kidney disease (CKD) is a global health concern and public health priority. The condition often involves inflammation due to the accumulation of toxins and the reduced clearance of inflammatory cytokines, leading to gradual loss of ...
Acetylation of the nuclear localization signal in Ku70 diminishes the interaction with importin-α [0.03%]
Ku70的核定位信号的乙酰化会减弱与输入蛋白-α的相互作用
Hirofumi Fujimoto,Togo Ikuta,Aki Koike et al.
Hirofumi Fujimoto et al.
Proteins are functionally regulated by various types of posttranslational modifications (PTMs). Ku, a heterodimer complex of Ku70 and Ku80 subunits, participates in DNA repair processes. Ku is distributed not only in the nucleus but also in...
Trichinella pseudospiralis-secreted 53 kDa protein ameliorates imiquimod-induced psoriasis by inhibiting the IL-23/IL-17 axis in mice [0.03%]
分泌型53kDa蛋白通过抑制IL-23/IL-17轴缓解斑蟊诱导的小鼠银屑病样症状
Sukhonthip Khueangchiangkhwang,Zhiliang Wu,Isao Nagano et al.
Sukhonthip Khueangchiangkhwang et al.
Trichinella infection can experimentally ameliorate many autoimmune diseases. However, the immune mechanism of the amelioration and the identification of corresponding Trichinella-derived molecule(s) are still not fully elucidated. Fifty-th...
Investigation of susceptibility genes for chickenpox disease across multiple continents [0.03%]
多大陆上水痘疾病易感基因的研究
Lalu Muhammad Irham,Wirawan Adikusuma,Lolita Lolita et al.
Lalu Muhammad Irham et al.
Chickenpox (varicella) is caused by infection with the varicella-zoster virus (VZV), a neurotropic alpha herpes virus with a double-stranded DNA genome. Chickenpox can cause life-threatening complications, including subsequent bacterial inf...
Modified method for differentiation of myeloid-derived suppressor cells in vitro enhances immunosuppressive ability via glutathione metabolism [0.03%]
通过谷胱甘肽代谢改进的体外髓源性抑制细胞分化方法可增强免疫抑制能力
Haoyang Zhou,Zhiqi Xie,Naosuke Morikawa et al.
Haoyang Zhou et al.
Myeloid-derived suppressor cells (MDSCs), which accumulate in tumor bearers, are known to suppress anti-tumor immunity and thus promote tumor progression. MDSCs are considered a major cause of resistance against immune checkpoint inhibitors...
MiR-7-5p attenuates vascular smooth muscle cell migration and intimal hyperplasia after vascular injury by NF-kB signaling [0.03%]
血管损伤后，MiR-7-5p通过NF-kB信号减弱血管平滑肌细胞迁移和内膜增生
Jixiang Yuan,Yun Kong
Jixiang Yuan
Background: Atherosclerosis (AS) is the primary cause of coronary artery disease, which is featured by aberrant proliferation, differentiation, and migration of vascular smooth muscle cells (VSMCs). MicroRNAs play crucial...
Investigating the effect of Shenmai injection on cardiac electrophysiology and calcium signaling using human-induced pluripotent stem cell-derived cardiomyocytes [0.03%]
使用人诱导多能干细胞来源的心肌细胞研究参麦注射液对心脏电生理及钙信号的影响
Zhang Zhang,Yuxin Li,Meihui Yan et al.
Zhang Zhang et al.
Traditional Chinese medicine injection (TCMI) refers to the use of modern technology to make Chinese patent medicines in injectable forms, which shorten the onset time of the traditional Chinese medicine (TCM). Although there have been clin...
Ubiquitin-like protein MNSFβ regulates glycolysis and promotes cell proliferation with HSC70 assistance [0.03%]
泛素类蛋白MNSFβ通过HSC70协助调节糖酵解和促进细胞增殖
Morihiko Nakamura,Kyoko Yamasaki,Megumi Kono
Morihiko Nakamura
Monoclonal non-specific suppressor factor β (MNSFβ) is a universally expressed ubiquitin-like protein that has multiple biological functions. MNSFβ modifies its target molecules through covalent conjugation. Most recently, we identified ...
Patrick M Keating,Hallie N Pennington,Shane D Collins et al.
Patrick M Keating et al.
Lassa virus (LASV) is the most prevalent arenavirus afflicting humans and has high potential to become a threat to global public health. The transmembrane domain (TM) of the LASV glycoprotein complex forms critical interactions with the LAS...