EGCG induces degradation of active folate in serum via H2O2 generation, while L-ascorbic acid effectively reverses this effect [0.03%]
EGCG通过生成H2O2诱导血清中活性叶酸分解，而L-抗坏血酸可有效逆转其影响
Guangbin Zhou,Mengmeng Zhang,Xiaoyu Sun et al.
Guangbin Zhou et al.
Empirical studies have indicated that excessive tea consumption may potentially decrease folate levels within the human body. The main active component in green tea, epigallocatechin gallate (EGCG), significantly reduces the concentration o...
Supplementation with NAD+ and its precursors: A rescue of female reproductive diseases [0.03%]
辅以NAD+及其前体物质对女性生殖疾病的治疗作用
Lan Li,Xin Zhou,Wene Liu et al.
Lan Li et al.
Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme involved in many pathophysiological processes. Supplementation with NAD+ and its precursors has been demonstrated as an emerging therapeutic strategy for the diseases. NAD+ a...
Soluble expression of recombinant coagulation factor IX protein using Escherichia coli [0.03%]
用于表达人凝血因子IX的可溶性基因工程菌的构建及诱导表达条件的优化
Byoung-Hee Park,Hanool Yun,Hee-Jin Jeong
Byoung-Hee Park
Hemophilia B is a congenital bleeding disorder caused by factor IX (FIX) deficiency. Generation of recombinant FIX (rFIX) is required for detecting a Hemophilia B indicator, anti-FIX antibody. In this study, we described a method for produc...
Preparation of stable and monodisperse paclitaxel-loaded bovine serum albumin nanoparticles via intermolecular disulfide crosslinking [0.03%]
通过分子间二硫键交联法制备稳定均一的紫杉醇-牛血清白蛋白纳米粒
Yusuke Kono,Tomoyuki Sugaya,Hikaru Yasudome et al.
Yusuke Kono et al.
Paclitaxel (PTX) is one of the most used anti-cancer drugs worldwide. Due to its insolubility in water, the clinically available liquid formulation of PTX contains Cremophor EL that is responsible for severe hypersensitivity. Albumin-based ...
Improved elution strategy and new monoclonal anti-biotin antibody for LC-MS/MS characterization of protein biotinylation sites [0.03%]
改进的洗脱策略和新的单克隆抗生物素抗体用于蛋白质生物素化位点的LC-MS/MS表征
Yiying Zhu
Yiying Zhu
Biotin labeling in combination with mass spectrometry has been widely applied in large-scale biological studies, such as determination of protein partners, protein subcellular localization, and protein post-translational modifications. Prev...
Targeting estrogen mediated CYP4F2/CYP4F11-20-HETE metabolic disorder decelerates tumorigenesis in ER+ breast cancer [0.03%]
靶向雌激素介导的CYP4F2/CYP4F11-20-HETE代谢紊乱可减缓ER+乳腺癌肿瘤发生速度
Juan Yang,Yin Li,Xiao Han et al.
Juan Yang et al.
Purpose: As the most common subset of breast cancer (BC), estrogen receptor positive (ER+) BC accounting for 80% of cases, has become a global public health concern. The female hormone estrogen (E2) unequivocally drives E...
A systematic computational analysis of the endosomal recycling pathway in glioblastoma [0.03%]
胶质母细胞瘤内吞循环途径的系统计算分析
Luke J Joyce,Andrew J Lindsay
Luke J Joyce
Glioblastoma (GBM) is the most common and aggressive brain cancer in adults. The standard treatment is brutal and has changed little in 20 years, and more than 85% of patients will die within two years of their diagnosis. There is thus an u...
The malignant transformation potential of the oncogene STYK1/NOK at early lymphocyte development in transgenic mice [0.03%]
致癌基因STYK1/NOK在转基因小鼠早期淋巴细胞发育过程中恶性转化的潜能
Yin Yang,Li Liu,Haley O Tucker
Yin Yang
B-cell Chronic Lymphocytic Leukemia (B-CLL) is a malignancy caused by the clonal expansion of mature B lymphocytes bearing a CD5+CD19+ (B1) phenotype. However, the origin of B-CLL remains controversial. We showed previously that STYK1/NOK t...
Liposome-encapsulated progesterone efficiently suppresses B-lineage cell proliferation [0.03%]
脂质体封装的孕酮有效抑制B淋巴系细胞增殖
Toshiro Seki,Rikio Suzuki,Shino Ohshima et al.
Toshiro Seki et al.
Progesterone suppresses several ancient pathways in a concentration-dependent manner. Based on these characteristics, progesterone is considered a candidate anticancer drug. However, the concentration of progesterone used for therapy should...
Slow pyrolysis of Terminalia catappa L. municipal solid waste and the use of the aqueous fraction produced for bovine mastitis control [0.03%]
慢速热解终端木荷城市固体废物及其产生的水相部分在牛乳腺炎控制中的应用
Rafaelle Vinturelle,Taissa da Silva Cabral,Pamella C O de Oliveira et al.
Rafaelle Vinturelle et al.
The Terminalia catappa L. tree is an ornamental and shade tree producter of a large amount of biological waste sent to landfills. Therefore, this plant constitutes so-called municipal solid wood waste (MSWW), which causes undesirable impact...