Adalia R Wambolt,Victor Martinez-Macias,Brian Foo et al.
Adalia R Wambolt et al.
Protein-conjugated Gold Nanoclusters (AuNC) are an emerging material with extensive applications in medicine and biotechnology. Previous works describe the use of casein proteins from bovine milk as a facile and economical scaffold for the ...
Elucidating cardiac fibroblasts heterogeneity and activation during experimental autoimmune myocarditis using spatial transcriptomics [0.03%]
使用空间转录组学阐明实验性自身免疫心肌炎过程中心脏纤维母细胞的异质性和活化状态
Monika Stefańska,Katarzyna Sarad,Marta Kot et al.
Monika Stefańska et al.
Dilated cardiomyopathy (DCM), which develops from myocardial inflammation, is frequently linked to a poor prognosis and fatal outcome. Experimental autoimmune myocarditis (EAM) serves as an animal model of CD4+ T cells-dependent acute myoca...
Integration of single-cell and RNA-seq analysis reveals sepsis heterogeneity and prognostic significance of FCGR3A+ Macrophage subtypes [0.03%]
单细胞和RNA测序分析的整合揭示了脓毒症的异质性和FCGR3A +巨噬细胞亚型的预后意义
Yijia He,Shuanghu Dong,Lifen Ouyang et al.
Yijia He et al.
Sepsis, a pressing global health challenge, is characterized by immune dysregulation and high mortality. This study, in response to this urgent need, integrated Single-cell RNA sequencing data from 53 samples and bulk transcriptomic data fr...
Analyzing qPCR data: Better practices to facilitate rigor and reproducibility [0.03%]
改善RT-qPCR数据分析实践以提高研究严谨性和可重复性
Thomas H Hampton,Lily Taub,Kiyoshi Ferreria-Fukutani et al.
Thomas H Hampton et al.
Quantitative PCR (qPCR) remains a widely used, cost-effective method for RNA quantitation, yet many published studies inadequately comply with MIQE (Minimum Information for Publication of Quantitative Real-Time PCR Experiments) and FAIR (Fi...
Decoding the interplay between COVID-19 and diabetic nephropathy through bioinformatics and systems biology techniques [0.03%]
利用生物信息学和系统生物学技术解码COVID-19与糖尿病肾病的相互作用关系
Xianxiang Chen,Qingle Zeng,Min Xia et al.
Xianxiang Chen et al.
Aims: Individuals with diabetic nephropathy (DN), a major diabetic complication, have been disproportionately affected by the coronavirus disease 2019 (COVID-19) pandemic. This study aimed to investigate the molecular int...
Gut microbiota signature in a cohort of Chinese patients with rosacea [0.03%]
中国 rosacea 患者队列的肠道微生物特征分析
Zheng Zhao,Lulu Lu,Yang Yi et al.
Zheng Zhao et al.
Background: Rosacea is a chronic inflammatory skin disease characterized by diverse symptoms and variable clinical progression, which can significantly impair patients' quality of life and mental health. The exact etiolog...
Effect of a chondroitin sulfate chain linked to the bikunin core peptide on gene expression in lipopolysaccharide-treated uterine cervical fibroblasts [0.03%]
透明质烷链结合桥坤肽对脂多糖处理的子宫颈纤维母细胞基因表达的影响
Saki Kurotaki,Ikuko Kakizaki,Kanji Tanaka et al.
Saki Kurotaki et al.
Bikunin is a proteoglycan with a core protein and a low sulfated chondroitin 4-sulfate (Ch4S) chain. This chain has low 4-sulfated glucuronic acid-N-acetylgalactosamine (GlcUAβ1-3GalNAcβ1-4) repeating disaccharide units, and is covalently...
Integrated bioinformatics analysis identifies cuproptosis and ferroptosis gene signatures via subgroup clustering: Prognostic and therapeutic implications in breast cancer [0.03%]
集成生物信息学分析通过亚组聚类识别铜依赖性细胞死亡和铁死亡基因标志物：乳腺癌预后和治疗意义
Yuqin Wei,Xingwen Wei,Wei Zhao
Yuqin Wei
Objective: This study aimed to investigate the prognostic value and biological implications of cuproptosis/ferroptosis-related genes in breast cancer, and to develop a robust molecular signature for risk stratification an...
Mechanisms of skin wound healing regulated by fibroblast-derived exosomes [0.03%]
成纤维细胞源外泌体调控皮肤伤口愈合的机制研究
Ye Qiu,Xingying Zhu,Xiaoqian Yang et al.
Ye Qiu et al.
Skin wound healing is a complex and highly coordinated biological process involving multiple cell types and signaling pathways, among which fibroblasts play a pivotal role. Exosomes, as nanoscale extracellular vesicles that mediate intercel...
Erythropoietin promotes cell proliferation in Neuro-2A mouse neuroblastoma cells [0.03%]
促红细胞生成素能促进神经母细胞瘤Neuro-2A细胞的增殖
Farooqahmed S Kittur,Finn Hynes,Naasir Albright et al.
Farooqahmed S Kittur et al.
Erythropoietin (Epo) is a glycoprotein hormone primarily known for regulating red blood cell production. Beyond erythropoiesis, Epo has been reported to exert tissue-protective effects, including neuroprotective and neuroregenerative proper...