Dynamics of enzyme and metabolic profile of broilers fed black soldier fly (Hermetiailucens) larvae-based diets [0.03%]
饲喂黑兵虫（赫尔梅蒂亚卢切尼亚丝） larva 基础日粮的肉鸡消化道内酶和代谢轮廓动态变化
Opeyemi Adetola Oladejo,Deborah Oluwaferanmi Ibiwoye,Ayodeji Amos Faniyi et al.
Opeyemi Adetola Oladejo et al.
This study investigated the impact of replacing fishmeal with black soldier fly larvae meal (BSFLM) on growth performance, microbial enzyme activity, and metabolic functions in broiler chickens. A total of fifty Arbor Acre Plus chicks were ...
O-GlcNAcylation: A bridge for regulating the function of the "heart-kidney-bone axis" [0.03%]
O-连接-N-乙酰葡萄糖胺(O-GlcNAc)修饰：调控“心-肾-骨轴”功能的桥梁作用
Shuangcui Wang,Maojuan Guo,Bo Yang et al.
Shuangcui Wang et al.
The three major organ systems of heart, kidney and bone are highly correlated in physiology and pathology. They form the "heart-kidney-bone axis" together. The typical clinical manifestations of this axis include the deterioration of heart ...
Targeting TLR4/non-canonical NF-κB pathway by Bushen Bitong recipe enhances BMSCs-based cartilage repair in osteoarthritis [0.03%]
补肾骨肽方通过靶向TLR4非经典NF-κB信号通路促进骨髓间充质干细胞软骨分化修复膝骨关节炎损伤
Wenyuan Xiang,Cheng Xiang,Atikul Islam et al.
Wenyuan Xiang et al.
Bushen Bitong Recipe (BSBT) is a traditional Chinese medicine used clinically for osteoarthritis, while bone marrow mesenchymal stromal cell (BMSCs) therapy is increasingly applied for its immunomodulatory and anti-inflammatory properties. ...
Tanshinone IIA attenuates psoriasis via Nrf2/HO-1 activation: Mechanistic insights from preclinical models [0.03%]
丹参酮IIA通过Nrf2/HO-1激活缓解银屑病：来自临床前模型的机制见解
Xia Xu,Jingyao Liang,Maofang Huang et al.
Xia Xu et al.
Background: Psoriasis is a chronic inflammatory skin disorder driven by oxidative stress and immune dysregulation. Tanshinone IIA, a bioactive compound from Salvia miltiorrhiza, exhibits antioxidant properties, but its ro...
Dysregulated serum levels of human tissue kallikreins, hK7 and hK10, as potential biomarkers of asthma [0.03%]
人组织激肽释放酶hK7和hK10失调的血清水平作为哮喘潜在生物标志物的可能性
Samina Ejaz,Faiz-Ul-Hassan Nasim,Iqra Abdullah et al.
Samina Ejaz et al.
Background: Asthma is a highly prevalent inflammatory disease worldwide with limited diagnostic and therapeutic approaches. Objective: ...
Different strategies to enhance the solubility of acylsucrose transferase PaxASAT1 expression in Escherichia coli [0.03%]
提高大肠杆菌中酰基蔗糖转移酶PaxASAT1表达可溶性的策略研究
Li Han,Xueming Yu,Yibo Ning et al.
Li Han et al.
Heterologous expression of soluble proteins is a crucial method for studying gene function and enzyme structure. Escherichia coli is a widely used host for expressing foreign genes from plants, animals, and microorganisms. PaxASAT1, a membe...
Overexpressed Spindlin1 relocalizes to the nucleoli during fixation [0.03%]
过度表达的Spindlin1在固定过程中重新定位到核仁中
Falk Ike Fischer,Antigona Pervetica,Marie Moeser et al.
Falk Ike Fischer et al.
The histone reader protein Spindlin1 has emerged as a pivotal player in tumorigenesis. Consequently, it became a major focus of research and numerous functions and interactions were proposed. In concert, varying subcellular distributions of...
Akiyo Fukuda,Yutaka Koyama,Yuya Denda et al.
Akiyo Fukuda et al.
Abdominal aortic aneurysm (AAA) is a life-threatening vascular disease, and its underlying mechanisms remain incompletely understood. Vascular smooth muscle cells (SMCs) are the predominant cell type in the aortic wall, and SMC dysfunction ...
Association between serum lipid-apolipoprotein alterations and soluble syndecan-1 dynamics in sepsis: impact of apolipoprotein E isoforms [0.03%]
血清脂质-载脂蛋白变化与脓毒症中可溶性硫酸乙酰肝素蛋白多糖-1动态变化之间的关系：载脂蛋白E亚型的影响
Riho Shimizu,Shogo Akahane,Harue Suzuki et al.
Riho Shimizu et al.
Background: Dyslipidemia is a common feature of sepsis; however, its relationship with inflammation-related biomarkers remains incompletely understood. This study aimed to examine the associations between soluble syndecan...
Integrated single-cell transcriptomic analysis identifies PF4 + /PPBP + megakaryocyte-like granulocytes associated with immune dysregulation in autoimmune diseases [0.03%]
整合单细胞转录组分析鉴定出PF4+ / PPBP+巨核细胞样颗粒细胞与自身免疫疾病中的免疫失调相关
Shaoqi Chen,Yu Fan,Miaotong Su et al.
Shaoqi Chen et al.
Objectives: Megakaryocytes (MKs) and low-density granulocytes (LDGs) are implicated in immune dysregulation and vascular pathology in autoimmune diseases (ADs), yet their precise subsets and pathological interactions rema...