Comprehensive characterization of the human neural stem cell line HNSC.100 as a versatile model for neurobiological research [0.03%]
人神经干细胞系HNSC.100的全面表征作为神经生物学研究的多功能模型
Estera Jeruzalska,Carolin Ketteler,Elisa Stützenberger et al.
Estera Jeruzalska et al.
Studying neural-related questions is inherently challenging due to the limited number of suitable cell models. Here, we characterize a previously reported immortalized human neural stem cell line, HNSC.100, serving as a robust model for a w...
Evolutionary divergence of nocturnin led to redox regulation in mammalian orthologs [0.03%]
夜宵蛋白的进化分化导致哺乳动物同源物中的氧化还原调控机制
Crystal A Olivas-Rasmussen,Peng Gao,Emil S Rasmussen et al.
Crystal A Olivas-Rasmussen et al.
NADP(H) and NAD(H) are essential cofactors involved in nearly 500 metabolic reactions, making them fundamental to cellular function and redox homeostasis. Loss of redox homeostasis through alterations in NADP(H) regulation has been implicat...
The Farnesoid X receptor-bile acid axis contributes to immune evasion in gastric cancer and its inhibition enhances efficacy of anti-PD-L1 therapy [0.03%]
法尼醇X受体-胆汁酸轴参与胃癌免疫逃逸并可通过抑制该轴增强抗PD-L1治疗疗效
Cristina Di Giorgio,Michele Biagioli,Silvia Marchianò et al.
Cristina Di Giorgio et al.
Gastric cancer ranks among the most prevalent malignancies globally and remains a major contributor to cancer-related mortality. Its progression is profoundly shaped by the tumor microenvironment (TME), a dynamic milieu comprising extracell...
Timosaponin B-II attenuates hemorrhagic transformation-driven acceleration of alzheimer disease-related pathology after ischemic stroke [0.03%]
脑卒中后出血转化促进阿尔茨海默病相关病理变化的加重及其机制研究
Yafen Dong,Xuesong Bai,Ye Chen et al.
Yafen Dong et al.
Hemorrhagic transformation (HT) is a major complication of reperfusion therapy after ischemic stroke, but its impact on Alzheimer disease (AD) progression remains unclear. In this study, we used an early-stage APP/PS1 mouse model and found ...
Irisin promotes selective changes in hippocampal mitochondrial metabolism in mice [0.03%]
irisin促进小鼠海马体线粒体代谢的特异性变化
Ariene S Fonseca,Marina S Chichierchio,Mariana G Chauvet et al.
Ariene S Fonseca et al.
Irisin, an exercise-induced hormone, exerts neuroprotective actions in neurological disease models, yet its effects on brain mitochondrial metabolism remain unclear. Here, we examined how irisin influences mitochondrial function and dynamic...
Role of Dlk1-Notch signaling in impaired neurogenesis and cognitive decline in chronic cerebral hypoperfusion [0.03%]
Dlk1-Notch信号在慢性脑低灌注所致神经发生及认知功能障碍小鼠中的作用研究
Yoshiyuki Moriyama,Rena Hasegawa,Hikaru Endo et al.
Yoshiyuki Moriyama et al.
Vascular dementia (VaD) is characterized by chronic cerebral hypoperfusion, leading to cognitive decline. Impaired hippocampal neurogenesis is a crucial pathological feature of VaD. Delta-like 1 homolog (Dlk1)-Notch signaling may contribute...
Exploratory comparison of PASC and SARS-CoV-2 infection through metabolomics and lipidomics in early pandemic and Omicron-era [0.03%]
通过代谢组学和脂质组学探索PASC与SARS-CoV-2感染在大流行早期阶段和奥密克戎时期的区别
Chelsea M Rock,Laura M Johnson,Adrianna L Westbrook et al.
Chelsea M Rock et al.
While symptomology of post-acute sequelae of COVID-19 (PASC) is well-known, and more risk factors are being identified, the physiological mechanisms of this condition remain largely undetermined. In the early pandemic into the pre-Omicron e...
Swimming exercise training (SET) and MitoQ supplementation can mitigate the atrophy and inflammation process in skeletal muscles of male Wistar rats with spinal cord injury (SCI): NF-κB/MuRF-1/proteasome pathway [0.03%]
游泳锻炼和MitoQ补充可以通过NF-κB/MuRF-1/蛋白酶体通路缓解脊髓损伤大鼠骨骼肌萎缩及炎症反应
Zahra Behroozi,Beydolah Shahouzehi,Daruosh Moflehi et al.
Zahra Behroozi et al.
In the present study, we investigated the effects of a rehabilitation period with MitoQ supplement and swimming exercise training (SET) on atrophy and the inflammation process in the skeletal muscles of male rats with spinal cord injury (SC...
The KLF4-inflammatory pathway is associated with paraquat-induced pulmonary injury and early pro-fibrotic responses [0.03%]
KLF4-炎症通路与百草枯诱导的肺损伤及早期促纤维化反应有关
Wei Zhang,Sisi Ye,Jiabao Chen et al.
Wei Zhang et al.
Paraquat, a highly toxic herbicide, frequently causes acute poisoning, predominantly inducing pulmonary injury and fibrosis with high mortality, and no specific antidote is available. This study aimed to explore its pathogenesis using a par...
Characterization of high-artemisinin yielding Artemisia annua bioecotypes using gene-specific STS markers and HPLC for quality-oriented selection [0.03%]
基于基因特异的STS标记和高效液相色谱的高质量青蒿素紫花蒿种质资源的鉴定研究
Mohammad Taher Hallajian,Sahar Tavakoli Mohammadi,Mohammad Ali Ebrahimi et al.
Mohammad Taher Hallajian et al.
Artemisia annua is the sole natural source of artemisinin, an essential compound for malaria treatment. However, variable yields among bioecotypes hinder consistent production. This study aimed to characterize 17 A. annua biotypes using gen...