Liquid-liquid phase-separated tau colocalizes with and stabilizes Aβ oligomers [0.03%]
液体-液体相分离的tau与老年素寡聚体共定位并稳定老年素寡聚体
Tina Jacob,Marie P Schützmann,Laurin Gerhards et al.
Tina Jacob et al.
Protein aggregation is a hallmark of neurodegenerative diseases, where misfolded proteins accumulate into insoluble deposits. Emerging studies indicate that liquid-liquid phase separation (LLPS) may serve as a transient stage in the transit...
Structure-based macrocyclization of α-ketoamides leads to potent inhibitors of coronaviral and enteroviral proteases [0.03%]
基于结构的α-酮胺类化合物巨环化导致冠状病毒和肠道病毒蛋白酶强效抑制剂的产生
Ravi Kumar Akula,Haifa El Kilani,Alina Metzen et al.
Ravi Kumar Akula et al.
Viral proteases represent validated targets for direct-acting antivirals and the treatment of associated infections. In co-crystal structures of Mpro of SARS-CoV-2 with peptidomimetic inhibitors, we noticed a spatial proximity of sidechains...
Insights into the Ir-O redox dynamics of an operating PEM water electrolyzer using in operando Raman spectroscopy [0.03%]
基于原位拉曼光谱的质子交换膜水电解槽Ir-O红氧物种动态研究
Sebastian Speer,Sven Jovanovic,Christina Oeß et al.
Sebastian Speer et al.
In operando Raman investigations of iridium-based oxygen evolution (OER) catalysts in water electrolysis offer insights into catalytically relevant species and pathways, enabling optimization towards effective use of iridium. This work buil...
Human chaperone DNAJB6b suppresses tau fibril formation through co-aggregation [0.03%]
人类分子伴侣DNAJB6b通过共聚集抑制tau原纤维形成
Andreas Carlsson,Emil Axell,Johan Wallerstein et al.
Andreas Carlsson et al.
The aggregation of the tau protein into intraneuronal fibrillar tangles is closely associated with the pathology of Alzheimer's disease. The endogenous defense system against this process includes molecular chaperones, among which DNAJB6b h...
Ultrafast chemistry [0.03%]
超快化学
Haiwang Yong
Haiwang Yong
Communications Chemistry is delighted to present a Collection of research articles highlighting recent developments in the field of ultrafast chemistry. Here, Editorial Board Member Professor Haiwang Yong introduces the topic and outlines t...
Conrad A P Goodwin
Conrad A P Goodwin
Communications Chemistry is pleased to present a Collection of research that explores the chemistry of the rare earths and the actinides. Here, Guest Editor Conrad Goodwin highlights key themes and looks towards the future of this field.
ZrO2-enhanced Ni@C catalysts for the selective hydrogenation of maleic anhydride to γ-butyrolactone [0.03%]
ZrO2改性的Ni@C催化剂催化顺酐选择性加氢制γ-丁内酯反应研究
Shuowen Guo,Yanyang Yao,Wei Wei et al.
Shuowen Guo et al.
Ni@C catalysts modified with ZrO2 (denoted as NiZr@C) were synthesized and evaluated for the liquid‑phase hydrogenation of maleic anhydride to γ‑butyrolactone. Characterization by XRD, TEM, XPS, H2‑TPD, ICP-OES, and in‑situ FTIR reveal...
Rapid and energy-efficient ultra-large library screening for drug discovery on a SpiNNaker2 neuromorphic chip [0.03%]
一种用于药物发现的超大库筛选的快速节能SpiNNaker2神经形态芯片方法
Johnny Alexander Jimenez Siegert,Florian Kelber,Bernhard Vogginger et al.
Johnny Alexander Jimenez Siegert et al.
The virtual screening of make-on-demand small molecule libraries can prioritize drug candidates for rapid experimental validation to accelerate pre-clinical drug discovery. As ultra-large libraries grow to billions of compounds, exhaustive ...
Streamlined synthesis of β-elemene using a spatially organized multi-enzyme machinery [0.03%]
利用空间组织的多酶体系简化合成β- elemene路径产物
Mijun Li,Chaoyue Nie,Xiangxiang Zuo et al.
Mijun Li et al.
β-Elemene is a pharmaceutically important sesquiterpene, while its production from plants and chemical synthesis remains inefficient. To achieve the efficient in vitro synthesis of β-elemene from low-cost mevalonate, a hexa-enzyme cascade...
A DFT-based Raman spectral atlas and vibrational assignment of aqueous glucose structures and derivatives [0.03%]
基于DFT的葡萄糖水合结构及衍生物拉曼光谱图集和振动指派
Kang Du,Meng Zhao,Tingting Wang et al.
Kang Du et al.
Diabetes mellitus affects approximately 589 million adults worldwide, underscoring the need for accurate and noninvasive glucose monitoring to reduce complications. Although Raman spectroscopy shows promise for noninvasive blood glucose det...