Human O-GlcNAcase catalytic-stalk dimer anchors flexible histone binding domains [0.03%]
人O-GlcNAc酶催化-茎二聚体锚定柔性的组蛋白结合结构域
Sarah B Nyenhuis,Agata Steenackers,Mana Mohan Mukherjee et al.
Sarah B Nyenhuis et al.
Although thousands of proteins are specifically O-GlcNAc modified, the molecular features recognized by the enzymes of O-GlcNAc cycling (OGT/OGA) remain poorly defined. Here we solved the structure of the long isoform of human OGA (OGA-L) b...
Systematic metabolite screening identifies functional regulators of the adenosine A2A receptor [0.03%]
系统性代谢物筛选鉴定出了腺苷A2A受体的功能调节因子
Prashant Rao,Manoj Rathinaswamy,Michelle Chan et al.
Prashant Rao et al.
The adenosine A2A receptor (A2AR) is a Class A G protein-coupled receptor (GPCR) that regulates inflammation, glucose metabolism, and energy homeostasis in metabolically active tissues. While the effects of small-molecule ligands and protei...
A theoretical study on the feasibility of 1,4-Copper migration in the Cu-catalyzed formal hydro(borylmethylsilyl)ation of internal alkynes [0.03%]
铜催化内部炔烃形式羟(硼基甲硅烷基)化中1,4-铜迁移的可行性研究理论研究
Song Liu,Wei Chen,Xinyu Long et al.
Song Liu et al.
The 1,n-metal migration process is distinct from traditional bond-forming pathways and offers a unique approach for constructing complex organic architectures. However, in contrast to the well-documented Pd-, Rh-, Fe-, Co-, and Ni-catalyzed...
Triply halogen-bridged erbium compounds with hard single-molecule magnet behavior [0.03%]
具有硬单分子磁行为的三重卤素桥接铒化合物
Qi-Wei Chen,You-Song Ding,Jia-Qi Huang et al.
Qi-Wei Chen et al.
Single-molecule magnets (SMMs) show promise for high-density data storage due to molecular-level magnetic hysteresis, but low-temperature quantum tunneling of magnetization (QTM) limits their blocking temperatures (TB), making QTM suppressi...
Stepped collisional energy improves protein acylation identification by eliminating positional bias of cyclic immonium ions [0.03%]
逐级碰撞能量通过消除环状酰亚胺离子的定位偏差来改善蛋白质烷基化鉴定
Zhao-Yu Zhu,Peng-Zhi Mao,Ching Tarn et al.
Zhao-Yu Zhu et al.
Mass spectrometry-based proteomics is indispensable for studying post-translational modifications. Cyclic immonium ions serve as invaluable diagnostic markers for lysine acylations, yet the principles governing their generation efficiency a...
Design of active sites for amine-functionalized direct air capture materials using integrated high-throughput calculations and machine learning [0.03%]
基于集成高通量计算和机器学习的胺功能化直接空气捕集材料活性位点设计
Megan C Davis,Wilton J M Kort-Kamp,Ivana Matanovic et al.
Megan C Davis et al.
Direct air capture (DAC) of carbon dioxide is a critical technology for mitigating climate change, but current materials face limitations in efficiency and scalability. We discover novel active sites for DAC materials using a combined machi...
Deep learning model of post-translational modification regulating liquid-liquid phase separation [0.03%]
深度学习模型：翻译后修饰调控液-液相分离
Xiaokun Hong,Jiyang Lv,Zhengxin Li et al.
Xiaokun Hong et al.
Liquid-liquid phase separation (LLPS) drives the formation of various membraneless organelles, which are crucial for biological processes and disease development. Despite the significant regulatory effects on LLPS of protein post-translatio...
Deficiency of Toll-like receptor 2 is a driver of sex-related compositional and structural rearrangements of membrane lipids [0.03%]
toll样受体2缺乏是驱动性别相关膜脂组成和结构重构的驱动因素
Raluca Sabina Ica,Kristina Mlinac-Jerkovic,Mario Stojanović et al.
Raluca Sabina Ica et al.
The behavior and function of membrane microdomains is shaped by the intricate liaison between the most complex glycosphingolipids-gangliosides, cholesterol and specific classes of transmembrane proteins. Toll-like receptor 2 (TLR2), a patte...
Metabolic engineering and late-stage functionalization expand the chemical space of the antimalarial premarineosin A [0.03%]
代谢工程和后期功能化拓展抗疟药物预麻黄素A的化学空间
Christina M McBride,Morgan McCauley,Natalia R Harris et al.
Christina M McBride et al.
Diversification of structurally complex natural products remains a key challenge in the discovery of next-generation therapeutics. Premarineosin A, a potent and selective antimalarial natural product, is a promising yet underexplored scaffo...
Conformational plasticity enables functional switching in diatom light-harvesting complexes [0.03%]
结构变构体在硅藻光捕获复合物功能转换中的作用
Theofani-Iosifina Sousani,Boutheina Zender,Sayan Maity et al.
Theofani-Iosifina Sousani et al.
Biomolecules exhibit a fundamental correlation between structure and function, which can be modulated by environmental factors. Deciphering this relationship remains a central and long-standing challenge for many protein families. In this s...