Advancing FAIR data towards comparable, organized, predictive AI-ready data for community validation [0.03%]
迈向可比、有序、预处理的AI就绪数据以实现社区验证的FAIR数据原则
Elisha M Wood-Charlson,Wolmar N Åkerström,Lindsey Anderson et al.
Elisha M Wood-Charlson et al.
The interrogation of data across biological and environmental systems has become increasingly complex. Fortunately, communities are adopting the FAIR (Findable, Accessible, Interoperable, Reusable) data principles for individual datasets, a...
Metatranscriptomics reveals urbanization-driven divergence in rodent viromes and zoonotic risks in Chinese megacities [0.03%]
元转录组揭示了中国特大城市啮齿动物病毒群和人畜共患病风险的差异性分布
Zhou-Fu Xiang,Hui Wang,Fan Yang et al.
Zhou-Fu Xiang et al.
Metagenomic sequencing has advanced our understanding of wildlife-associated viruses and enabled identification of potential zoonotic pathogens. However, most studies remain geographically limited, with few systematic comparisons of virome ...
Auditory network persistence of stimulus representation in awake and naturally sleeping mice [0.03%]
觉醒和自然睡眠小鼠的听觉网络刺激表征持续性
Barak Hadad,Noa Regev,Uddi Kimchy et al.
Barak Hadad et al.
Persistent neural activity often outlasts sensory stimulation, forming a bridge between perception and action. Such activity has been associated commonly with working memory, decision making, and action preparation under active task conditi...
RBM15 impairs Hepatic Mitochondria and β-Oxidation through m6A-dependent degradation of MCM3 mRNA [0.03%]
RBM15通过m6A依赖性降解MCM3 mRNA损害肝线粒体和β-氧化
Kai Chen,Yi Xiang,Daqing Deng et al.
Kai Chen et al.
Diabesity, defined as obesity accompanied by Type 2 diabetes mellitus, is characterized by metabolic dysfunction and mitochondrial impairment. Here, we investigate the role of N6-methyladenosine (m6A)-mediated RNA regulation in regulating h...
Ancient Mycobacterium leprae genomes reveal a potential origin and dispersal of the ancestral Branch 0 [0.03%]
古基因组揭示了分支0型麻风杆菌的潜在起源和传播方向
Shuang Fu,Xingyu Lin,Ying Nie et al.
Shuang Fu et al.
Although previous studies have examined numerous ancient Mycobacterium leprae genomes, the available strains remain concentrated in western Eurasia. Ancient genomes from eastern Eurasia have remained virtually unexplored, limiting our abili...
Evolution, structure and function of the putative biosynthetic gene cluster of the fungal secondary metabolite myriocin, a potent inhibitory sphingolipid [0.03%]
麦角菌次级代谢产物myriocin（一种强力抑制鞘脂）的生物合成基因簇的进化、结构和功能
Ben Rutter,Michael A Herrera,Gustavo Perez Ortiz et al.
Ben Rutter et al.
Myriocin is a fungal secondary metabolite exploited worldwide as a powerful inhibitor of sphingolipid biosynthesis through its structural similarity to sphingosine. We identify the putative myriocin biosynthesis gene cluster (BGC) through d...
Paradoxical regional contrasts in the resilience of marine zooplankton to climatic warming [0.03%]
气候变暖背景下海洋浮游动物适应力的区域差异悖论
Stefano Corona,Andrew Hirst,David Atkinson et al.
Stefano Corona et al.
To investigate the integrated response of plankton to climate warming, we measured simultaneous shifts in abundance, geographic range and phenology of eight copepod taxa across the North Sea and NE Atlantic over 6 decades. Here we show that...
Genetic and functional evidence links tgfbr2 to Nocardia seriolae resistance in spotted sea bass [0.03%]
遗传学和功能证据表明tgfbr2与点斑鰤鱼对诺卡氏菌的抗性有关
Yani Dong,Chong Zhang,Yonghang Zhang et al.
Yani Dong et al.
Spotted sea bass (Lateolabrax maculatus) is an economically important aquaculture species in China, but nocardiosis caused by Nocardia seriolae results in high mortality and economic losses. To investigate the genetic basis of disease resis...
Temporal transcriptomic and chromatin dynamics underlying class-level recognition in cleaner wrasse [0.03%]
ubar>关于印尼综合清洁虾虎鱼种水平识别的转录组和染色质动态ubar
Daniele Romeo,Celia Schunter
Daniele Romeo
Class-level recognition, whereby receivers learn signaller cues and associate them with class-specific information such as familiarity, guides partner choice in mutualisms and supports community stability. Yet its molecular basis is poorly ...
Idris Matine,Frederick Clasen,Fernando Garcia Guevara et al.
Idris Matine et al.
Microbial biosynthetic gene clusters (BGCs) encode diverse bioactive molecules but remain mostly silent under lab conditions, reflecting a balance between regulatory control and the metabolic cost of secondary metabolite production. While a...