Retentive Network promotes efficient RNA language modeling of long sequences [0.03%]
Retention网络促进长序列的高效RNA语言模型化
Yi Shen,Guangshuo Cao,Yueming Hu et al.
Yi Shen et al.
The latent features of RNA sequences are crucial for our understanding of their functions. Thus, Transformer-based nucleotide language models have received widespread attention; however, the O(n²) complexity of Transformer limits their abi...
Bryce J Carpenter,Margaux Lecacheur,Yannick N Mangold et al.
Bryce J Carpenter et al.
Disruption of the circadian clock as well as reduced NAD+ levels are both hallmarks of aging. While circadian rhythms and NAD+ metabolism have been linked in heart disease, their relationship during cardiac aging is less clear. Here, we sho...
Cilia-driven surface currents characterize specific cnidarian groups and lifecycle stages [0.03%]
纤毛驱动的表面水流表征特定水母纲群体和生活史阶段
Theres Koch,Karina Araslanova,Thibault Bouderlique et al.
Theres Koch et al.
In sessile animals, body surface-associated water currents are essential for integrating feeding, cleaning, and boosting metabolic exchange across colonies or communities of solitary individuals. The evolutionary origins of surface currents...
Antimicrobial resistance dissemination via horizontal gene transfer is constrained in stratified waters [0.03%]
分层水域中的抗菌药物抗性水平基因转移传播受到限制
Máté Vass,Anna Abramova,Johan Bengtsson-Palme
Máté Vass
Aquatic ecosystems are major reservoirs of antibiotic resistance genes (ARGs) and hubs for microbial interactions that can facilitate their spread through horizontal gene transfer (HGT). While mobile genetic elements (MGEs), including plasm...
Distinct perceptual and conceptual representations of natural actions along the lateral and dorsal visual streams [0.03%]
自然动作在视觉通路的侧部和背侧的不同知觉与概念表征
Diana C Dima,Jody C Culham,Yalda Mohsenzadeh
Diana C Dima
Actions are the building blocks of our dynamic visual world, yet the neural computations supporting action perception are not well understood. How does perceptual and conceptual information unfold in the brain when we observe what others ar...
Naomi Chaix-Eichel,Ayrton Guerillon,Sacha Bourgeois-Gironde et al.
Naomi Chaix-Eichel et al.
Primates' decision-making in economic contexts follows distinctive patterns, as initially described by Prospect Theory. Social animals, such as monkeys, live in hierarchically structured groups where individual status may influence cognitiv...
Early postsynaptic instability and acetylcholine receptor compartmentalization precede neuromuscular synapse dismantling [0.03%]
乙酰胆碱受体区室化现象先于神经肌肉突触解体出现及其后发生的突触后期不稳定性现象
Diego Zelada,Francisca Bermedo-García,Jessica Mella et al.
Diego Zelada et al.
The neuromuscular junction (NMJ) is the peripheral synapse controlling muscle contraction. Although aging and neurodegeneration result in NMJ denervation and synaptic dismantling, early indicators of this process remain elusive. Here, we an...
Structural basis for antibody cross-neutralization of Dengue and Zika viruses [0.03%]
登革病毒和寨卡病毒的交叉中和抗体的作用机制
Nicholas K Hurlburt,Jay Lubow,Leslie Goo et al.
Nicholas K Hurlburt et al.
Safe and effective vaccines against co-circulating mosquito-borne orthoflaviviruses such as Zika virus (ZikV) and the four serotypes of Dengue virus (DenV1-4) must elicit broadly neutralizing antibodies (bnAbs) to prevent the risk of enhanc...
Fructose-2,6-bisphosphate restores TDP-43 pathology-driven genome repair deficiency in motor neuron diseases [0.03%]
果糖-2,6-二磷酸可修复TDP-43病理性驱动的运动神经元疾病基因组修复缺陷
Anirban Chakraborty,Joy Mitra,Vikas H Malojirao et al.
Anirban Chakraborty et al.
TDP-43 proteinopathy is central to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). TDP-43 plays a key role in DNA double-strand break repair (DSBR), though the underlying mechanisms remain unclear. Here, we demonstrat...
A trimeric architecture reveals the glucitol PTS transporter as a distinct superfamily [0.03%]
三聚体结构揭示糖醇型PTS转运蛋白为独特超家族
Tingyue Deng,Xueli Liu,Jianwei Zeng et al.
Tingyue Deng et al.
The bacterial phosphoenolpyruvate:sugar phosphotransferase system (PTS) catalyzes the transport and phosphorylation of carbohydrates. The glucitol (Gut) PTS transporter from Escherichia coli has often been discussed in relation to the Gluco...