Repetition-related reductions in neural activity support improved behavior through increases in oscillatory power [0.03%]
神经活动通过振荡功率的增加来支持行为的改善
Adrian W Gilmore,Leonardo Claudino,Cassandra M Levesque et al.
Adrian W Gilmore et al.
Repeatedly processing an object leads to subsequent behavioral improvements in its identification and reductions in associated neural activity, a form of neural processing efficiency that multiple theoretical models have attempted to explai...
Synchrony between brain age and internalising and externalising symptoms across adolescence [0.03%]
青少年期大脑年龄与内部化和外部化症状之间的同步性
Dani Beck,Chloe Carrick,Eira R Aksnes et al.
Dani Beck et al.
Adolescence is a period of rapid neurobiological and behavioural change, yet how brain maturation deviations relate to psychopathology remains unclear. Here, we show, using data from the Adolescent Brain Cognitive Development Study, that de...
Mosaic chromosomal alterations are suppressed in older adults with HIV [0.03%]
人类免疫缺陷病毒(HIV)感染宿主的染色体镶嵌型改变在老年人中受到抑制
Kiarash Behrouzfar,Win Min Han,Rashindrie Perera et al.
Kiarash Behrouzfar et al.
Somatic gene mutations (SGMs) that drive clonal haematopoiesis (CH) have been shown to be more prevalent in people with HIV (PWH), potentially contributing to the higher risk of comorbidities in PWH compared to those without HIV. It is unkn...
DNA methylation reprogramming of gene regulatory elements is associated with lung metastasis in triple-negative breast cancer [0.03%]
三阴性乳腺癌中基因调控元件的DNA甲基化重编程与肺转移相关
Andrés F Bedoya-López,Sandra Íñiguez-Muñoz,Javier I J Orozco et al.
Andrés F Bedoya-López et al.
Triple-negative breast cancer (TNBC) is a major cause of cancer mortality, with distant metastases, particularly to the lungs, presenting a significant clinical challenge. While epigenetic mechanisms like DNA methylation (DNAm) are known to...
A telomere-to-telomere genome reveals arachidonic acid as a key regulator of hepatic lipid metabolism during hibernation [0.03%]
端粒到端粒基因组揭示了花生四烯酸在冬眠期间作为肝脂代谢的关键调节因子
Linjuan Wang,Pengyu Chen,Qingjing Gao et al.
Linjuan Wang et al.
Elucidating the molecular mechanisms governing mammalian hibernation is crucial for understanding energy homeostasis and physiological adaptation to extreme environments. In this study, we present the first high-quality telomere-to-telomere...
Feihong Liu,Jiameng Liu,Jinchen Gu et al.
Feihong Liu et al.
How multisystem white-matter maturation supports early speech acquisition in infancy remains unclear. Using longitudinal diffusion MRI from the Baby Connectome Project, we quantified neurite density maturation from birth to 24 months across...
Prohibitin 2 is a key regulator of T cell proliferation, differentiation, and effector functions in vivo [0.03%]
prohibitin 2 是体内 t 细胞增殖、分化和效应功能的关键调节因子
Johannes F Vogt,Carsten Merkwirth,Petra Adams-Quack et al.
Johannes F Vogt et al.
Prohibitin 2 (PHB2) is a highly conserved protein with essential roles in cell homeostasis and survival across different cell types. Previous studies have shown that the deletion of PHB2 results in an arrest in proliferation due to impaired...
Candidatus Bartonella xiongi influences iron homeostasis in the hematophagous mite Dermanyssus gallinae, affecting its reproduction [0.03%]
卡巴尔顿菌新龙阳种影响嗜血性鸡羽螨铁稳态，进而影响其繁殖能力
Tiancong Sun,Qi Liu,Penglong Wang et al.
Tiancong Sun et al.
Iron is an essential element for most organisms, including hematophagous arthropods, which are critical vectors for dozens of pathogens, seriously affecting the health of human beings and livestock. The mechanisms of iron acquisition by hem...
USP32-mediated stabilization of MAPK12 promotes lung adenocarcinoma progression by inhibiting autophagy-ferroptosis [0.03%]
USP32介导的MAPK12稳定促进肺癌进展通过抑制自噬-铁死亡
Qiang Zhang,Hongxu Sheng,Dongnan Ping et al.
Qiang Zhang et al.
Lung adenocarcinoma (LUAD), the most common non-small cell lung cancer, often resists ferroptosis and autophagy-two tumor-suppressive, therapy-sensitive regulated cell death pathways. MAPK12 (a stress-responsive p38 MAPK kinase) boosts LUAD...
Jiahao Ma,Hongzong Li,Jian-Dong Huang et al.
Jiahao Ma et al.
Pretrained models, originally developed for vision and textual data, are not a panacea and may fail to fully represent the complexity of sequences in immunological tasks. In studying pretrained immunological sequence modules of a renowned i...